PT668906E - Metodo para a producao de polipeptios por fermentacao bacteriana - Google Patents

Metodo para a producao de polipeptios por fermentacao bacteriana

Info

Publication number
PT668906E
PT668906E PT94901628T PT94901628T PT668906E PT 668906 E PT668906 E PT 668906E PT 94901628 T PT94901628 T PT 94901628T PT 94901628 T PT94901628 T PT 94901628T PT 668906 E PT668906 E PT 668906E
Authority
PT
Portugal
Prior art keywords
polypeptios
production
bacterial fermentation
propensity
fermented
Prior art date
Application number
PT94901628T
Other languages
English (en)
Inventor
James R Swartz
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PT668906E publication Critical patent/PT668906E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B01F23/2336—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the location of the place of introduction of the gas relative to the stirrer
    • B01F23/23362—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the location of the place of introduction of the gas relative to the stirrer the gas being introduced under the stirrer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/237—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media
    • B01F23/2376—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media characterised by the gas being introduced
    • B01F23/23761—Aerating, i.e. introducing oxygen containing gas in liquids
    • B01F23/237612—Oxygen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/213—Measuring of the properties of the mixtures, e.g. temperature, density or colour
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/2132—Concentration, pH, pOH, p(ION) or oxygen-demand
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2211—Amount of delivered fluid during a period
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/28—Means for regulation, monitoring, measurement or control, e.g. flow regulation of redox potential
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B01F23/2331—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the introduction of the gas along the axis of the stirrer or along the stirrer elements
    • B01F23/23316—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the introduction of the gas along the axis of the stirrer or along the stirrer elements through a separate hollow guide substantially parallel with the stirrer element

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT94901628T 1992-11-23 1993-11-19 Metodo para a producao de polipeptios por fermentacao bacteriana PT668906E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/989,844 US5342763A (en) 1992-11-23 1992-11-23 Method for producing polypeptide via bacterial fermentation

Publications (1)

Publication Number Publication Date
PT668906E true PT668906E (pt) 2005-02-28

Family

ID=25535522

Family Applications (2)

Application Number Title Priority Date Filing Date
PT04017942T PT1524316E (pt) 1992-11-23 1993-11-19 Método para a determinação da propensão de bactérias para instabilidade do oxigénio dissolvido
PT94901628T PT668906E (pt) 1992-11-23 1993-11-19 Metodo para a producao de polipeptios por fermentacao bacteriana

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT04017942T PT1524316E (pt) 1992-11-23 1993-11-19 Método para a determinação da propensão de bactérias para instabilidade do oxigénio dissolvido

Country Status (12)

Country Link
US (3) US5342763A (pt)
EP (2) EP0668906B1 (pt)
JP (2) JP3513875B2 (pt)
AT (2) ATE280223T1 (pt)
AU (2) AU669414B2 (pt)
CA (1) CA2147468C (pt)
DE (2) DE69334286D1 (pt)
DK (2) DK1524316T3 (pt)
ES (2) ES2231771T3 (pt)
IL (1) IL107712A (pt)
PT (2) PT1524316E (pt)
WO (1) WO1994012630A2 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342763A (en) * 1992-11-23 1994-08-30 Genentech, Inc. Method for producing polypeptide via bacterial fermentation
US6274369B1 (en) * 1996-02-02 2001-08-14 Invitrogen Corporation Method capable of increasing competency of bacterial cell transformation
US6027888A (en) * 1996-04-05 2000-02-22 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide-bond containing eukaryotic proteins in bacterial cells
ZA979496B (en) * 1996-10-31 1999-04-23 Genentech Inc Assay using marked microbial host cell strains
US6114137A (en) * 1996-10-31 2000-09-05 Genentech Inc Assay using marked microbial host cell strains
ATE386126T1 (de) * 1996-11-08 2008-03-15 Neose Technologies Inc Verbesserte expressionsvektoren
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
PT1141014E (pt) * 1999-01-06 2005-04-29 Genentech Inc Variante mutante do factor de crescimento semelhante a insulina (igf-i)
JP2002535967A (ja) 1999-01-06 2002-10-29 ジェネンテック・インコーポレーテッド インシュリン様成長因子（ｉｇｆ）ｉ変異体
EP1282437B1 (en) 2000-05-16 2008-03-19 Genentech, Inc. Treatment of cartilage disorders
SE0003958D0 (sv) 2000-10-31 2000-10-31 Biogaia Fermentation Ab Method for growth of microorganisms
ATE426674T1 (de) 2000-11-03 2009-04-15 Genentech Inc Stoffwechselanderungen in garungen zur produktion rekombinanter proteine
EP1401476A4 (en) * 2001-03-14 2006-03-08 Genentech Inc IGF ANTAGONIST PEPTIDES
EP1590445A4 (en) * 2003-01-16 2006-02-01 Fredric R Bloom BACTERIA FOR HIGH PERFORMANCE CLONES
US7249880B2 (en) * 2003-10-14 2007-07-31 Advanced Technology Materials, Inc. Flexible mixing bag for mixing solids, liquids and gases
PL1733037T3 (pl) * 2004-03-11 2015-04-30 Genentech Inc Sposób wytwarzania polipeptydów
US7078201B2 (en) * 2004-12-01 2006-07-18 Burmaster Brian M Ethanol fermentation using oxidation reduction potential
EP2290086A3 (en) 2004-12-22 2011-10-19 Genentech, Inc. Methods for producing soluble multi-membrane-spanning proteins
AU2006236662B2 (en) * 2005-04-15 2010-04-29 Garrett W. Brown Equipoising support apparatus
JP4358785B2 (ja) * 2005-05-27 2009-11-04 麒麟麦酒株式会社 密封容器内の酸素量の測定方法及びこれに用いる密封容器のピアス装置
US20090130757A1 (en) * 2005-10-26 2009-05-21 Terentiev Alexandre N Bioreactor with mixer and sparger
CA2633554C (en) 2005-12-22 2012-11-13 Genetech, Inc. Recombinant production of heparin binding proteins
DE102006001623B4 (de) * 2006-01-11 2009-05-07 Sartorius Stedim Biotech Gmbh Behälter und Verfahren zum Mischen von Medien
WO2008005611A2 (en) * 2006-04-21 2008-01-10 Advanced Technology Materials, Inc. Systems and devices for mixing substances and methods of making same
US10632433B2 (en) * 2006-05-13 2020-04-28 Pall Life Sciences Belgium Bvba Disposable bioreactor
JP2009072133A (ja) * 2007-09-21 2009-04-09 Hitachi Plant Technologies Ltd 培養槽装置、細胞培養方法及び物質生産方法
EP2216395A1 (en) 2009-02-09 2010-08-11 Lonza Biologics plc. Bioreactor for the cultivation of mammalian cells
SI2437874T1 (sl) * 2009-06-05 2015-08-31 F. Hoffmann-La Roche Ag Naprava za gojenje celic
BRPI1010068A2 (pt) * 2009-07-24 2016-03-15 Hoffmann La Roche "sistema agitador, dispositivo, método para cultivo de células animais, método para produzir um polipeptídeo, uso de um sistema agitador e dispositivos para cultivar células animais"
US20140024090A1 (en) * 2011-12-19 2014-01-23 Shell Oil Company Method and apparatus for converting a carbon source into a hydrocarbon or hydrocarbon precursor
CN114728871A (zh) * 2019-10-30 2022-07-08 基因组股份公司 用于减少副产物的微生物和方法

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US3384553A (en) * 1965-04-08 1968-05-21 Ceskoslovenska Akademie Ved Method and equipment for aerobic fermentation on liquid culture mediums
US3445342A (en) * 1966-02-11 1969-05-20 New Brunswick Scientific Co Fermentation apparatus
US3445341A (en) * 1966-06-17 1969-05-20 New Brunswick Scientific Co Fermentation apparatus with sterilization capabilities
US4116778A (en) * 1974-01-10 1978-09-26 Viktor Vasilievich Belousov Plant for continuous cultivation of microorganisms
US4064015A (en) * 1975-05-12 1977-12-20 New Brunswick Scientific Co., Inc. Control of biosynthesis in submerged culture
US4468455A (en) * 1980-12-02 1984-08-28 Phillips Petroleum Company Cell culture control
US4476224A (en) * 1982-05-10 1984-10-09 Adler Howard I Material and method for promoting the growth of anaerobic bacteria
US4762784A (en) * 1985-07-15 1988-08-09 International Minerals & Chemical Corp. Fermemtation process for the high level production of bovine growth hormone
US5049493A (en) * 1987-10-23 1991-09-17 California Institute Of Technology Enhancement of cell growth by expression of a cloned hemoglobin gene
US4882283A (en) * 1987-11-17 1989-11-21 Phillips Petroleum Company Heat exchange apparatus
US5182195A (en) * 1987-11-13 1993-01-26 Takeda Chemical Industries, Ltd. Method for increasing gene expression using protease deficient yeasts
BE1008008A3 (fr) * 1990-11-30 1995-12-12 Ajinomoto Kk Procede et appareil pour regler la concentration en source de carbone dans la culture aerobie d'un micro-organisme.
US5342763A (en) * 1992-11-23 1994-08-30 Genentech, Inc. Method for producing polypeptide via bacterial fermentation

Also Published As

Publication number Publication date
DE69333671T2 (de) 2006-01-19
US5633165A (en) 1997-05-27
ES2231771T3 (es) 2005-05-16
EP1524316A3 (en) 2005-04-27
EP1524316A2 (en) 2005-04-20
CA2147468C (en) 2006-05-16
DK0668906T3 (da) 2005-02-07
EP0668906B1 (en) 2004-10-20
DE69333671D1 (de) 2004-11-25
ATE432344T1 (de) 2009-06-15
IL107712A (en) 2002-09-12
PT1524316E (pt) 2009-08-13
CA2147468A1 (en) 1994-06-09
IL107712A0 (en) 1994-02-27
ES2326802T3 (es) 2009-10-20
AU679880B2 (en) 1997-07-10
AU5615094A (en) 1994-06-22
JP3513875B2 (ja) 2004-03-31
JP3674705B2 (ja) 2005-07-20
US5487980A (en) 1996-01-30
WO1994012630A3 (en) 1994-10-13
EP0668906A1 (en) 1995-08-30
EP1524316B1 (en) 2009-05-27
JP2004121256A (ja) 2004-04-22
AU669414B2 (en) 1996-06-06
US5342763A (en) 1994-08-30
JPH08503611A (ja) 1996-04-23
AU5946196A (en) 1996-09-05
ATE280223T1 (de) 2004-11-15
WO1994012630A2 (en) 1994-06-09
DE69334286D1 (de) 2009-07-09
DK1524316T3 (da) 2009-09-07

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