IL107092A - Renin inhibiting n-(2-amino- 2-oxoethyl) butanediamide derivatives, their preparation and pharmaceutical compositions containing them - Google Patents
Renin inhibiting n-(2-amino- 2-oxoethyl) butanediamide derivatives, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL107092A IL107092A IL107092A IL10709293A IL107092A IL 107092 A IL107092 A IL 107092A IL 107092 A IL107092 A IL 107092A IL 10709293 A IL10709293 A IL 10709293A IL 107092 A IL107092 A IL 107092A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- amino
- oxoethyl
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 102100028255 Renin Human genes 0.000 title abstract 2
- 108090000783 Renin Proteins 0.000 title abstract 2
- SNCZNSNPXMPCGN-UHFFFAOYSA-N butanediamide Chemical class NC(=O)CCC(N)=O SNCZNSNPXMPCGN-UHFFFAOYSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 2-(2-pyridinyl)ethyl Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000003287 1H-imidazol-4-ylmethyl group Chemical group [H]N1C([H])=NC(C([H])([H])[*])=C1[H] 0.000 abstract 1
- 102000004881 Angiotensinogen Human genes 0.000 abstract 1
- 108090001067 Angiotensinogen Proteins 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000005505 thiomorpholino group Chemical group 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95147892A | 1992-09-25 | 1992-09-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL107092A0 IL107092A0 (en) | 1993-12-28 |
| IL107092A true IL107092A (en) | 1997-09-30 |
Family
ID=25491725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL107092A IL107092A (en) | 1992-09-25 | 1993-09-23 | Renin inhibiting n-(2-amino- 2-oxoethyl) butanediamide derivatives, their preparation and pharmaceutical compositions containing them |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5541163A (fr) |
| EP (1) | EP0589445B1 (fr) |
| JP (1) | JP3490442B2 (fr) |
| KR (1) | KR950703520A (fr) |
| CN (1) | CN1090278A (fr) |
| AT (1) | ATE147720T1 (fr) |
| AU (1) | AU680829B2 (fr) |
| BG (1) | BG99542A (fr) |
| BR (1) | BR9307110A (fr) |
| CA (1) | CA2143300C (fr) |
| CO (1) | CO4560549A1 (fr) |
| CZ (1) | CZ74895A3 (fr) |
| DE (1) | DE69307446T2 (fr) |
| EE (1) | EE03083B1 (fr) |
| FI (1) | FI951398A0 (fr) |
| HU (2) | HUT70432A (fr) |
| IL (1) | IL107092A (fr) |
| LT (1) | LT3072B (fr) |
| LV (1) | LV10945B (fr) |
| MX (1) | MX9305918A (fr) |
| NO (1) | NO951133L (fr) |
| NZ (1) | NZ255301A (fr) |
| PH (1) | PH30881A (fr) |
| PL (1) | PL174454B1 (fr) |
| RU (1) | RU95113586A (fr) |
| SK (1) | SK37695A3 (fr) |
| TW (1) | TW239117B (fr) |
| WO (1) | WO1994007846A1 (fr) |
| ZA (1) | ZA937079B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL174487B1 (pl) * | 1992-09-25 | 1998-08-31 | Boehringer Ingelheim Canada | Nowe związki, pochodne N-(hydroksyetylo)butanodiamidu i sposób wytwarzania nowych pochodnych N-(hydroksyetylo)butanodiamidu |
| CA2165996C (fr) * | 1995-12-22 | 2002-01-29 | Murray Douglas Bailey | Preparation stereoselective de composes de type succinique avec substitution en 2 |
| US6096759A (en) | 1997-09-19 | 2000-08-01 | Georgetown University | Method for treating essential hypertension |
| US20050209141A1 (en) * | 2003-10-17 | 2005-09-22 | Silver Randi B | Mast cell-derived renin |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5006511A (en) * | 1981-10-14 | 1991-04-09 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa |
| EP0278158A3 (fr) | 1986-11-12 | 1990-05-23 | Merck & Co. Inc. | Inhibiteurs de rénine contenant des remplaçants de phénylalanyl-histidine |
| US4839357A (en) | 1987-10-02 | 1989-06-13 | Merck & Co., Inc. | Renin inhibitors containing phenylalanyl-histidine replacements |
| EP0312283A3 (fr) * | 1987-10-14 | 1990-05-09 | Merck & Co. Inc. | Inhibiteurs de la rénine di-ou tripeptidiques, contenant une restriction conformationnelle du type lactame dans ACHPA |
| US5001113A (en) | 1987-10-14 | 1991-03-19 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA |
| US5055466A (en) * | 1987-11-23 | 1991-10-08 | E. R. Squibb & Sons, Inc. | N-morpholino derivatives and their use as anti-hypertensive agents |
| CA1329680C (fr) * | 1987-11-23 | 1994-05-17 | Harold Norris Weller, Iii | Derives d'un alcool n-heterocyclique |
| AU615313B2 (en) * | 1988-07-01 | 1991-09-26 | G.D. Searle & Co. | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents |
| US5063208A (en) * | 1989-07-26 | 1991-11-05 | Abbott Laboratories | Peptidyl aminodiol renin inhibitors |
| IE902446A1 (en) * | 1989-07-26 | 1991-02-13 | Abbott Lab | Peptidyl aminodiol renin inhibitors |
| FI904441A0 (fi) * | 1989-09-12 | 1990-09-10 | Hoechst Ag | Aminosyraderivat med reninhaemmande egenskaper, foerfaranden foer deras framstaellning, dessa innehaollande aemnen och deras anvaendning. |
| JPH0532602A (ja) * | 1991-07-26 | 1993-02-09 | Terumo Corp | ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤 |
-
1993
- 1993-09-15 HU HU9500871A patent/HUT70432A/hu unknown
- 1993-09-15 PL PL93308180A patent/PL174454B1/pl unknown
- 1993-09-15 NZ NZ255301A patent/NZ255301A/en unknown
- 1993-09-15 AU AU49403/93A patent/AU680829B2/en not_active Ceased
- 1993-09-15 CZ CZ95748A patent/CZ74895A3/cs unknown
- 1993-09-15 RU RU95113586/04A patent/RU95113586A/ru unknown
- 1993-09-15 BR BR9307110A patent/BR9307110A/pt not_active Application Discontinuation
- 1993-09-15 SK SK376-95A patent/SK37695A3/sk unknown
- 1993-09-15 CA CA002143300A patent/CA2143300C/fr not_active Expired - Fee Related
- 1993-09-15 JP JP50854294A patent/JP3490442B2/ja not_active Expired - Fee Related
- 1993-09-15 WO PCT/CA1993/000380 patent/WO1994007846A1/fr not_active Application Discontinuation
- 1993-09-15 KR KR1019950701149A patent/KR950703520A/ko not_active Application Discontinuation
- 1993-09-17 US US08/122,280 patent/US5541163A/en not_active Expired - Lifetime
- 1993-09-23 PH PH46946A patent/PH30881A/en unknown
- 1993-09-23 EP EP93115326A patent/EP0589445B1/fr not_active Expired - Lifetime
- 1993-09-23 DE DE69307446T patent/DE69307446T2/de not_active Expired - Lifetime
- 1993-09-23 IL IL107092A patent/IL107092A/xx not_active IP Right Cessation
- 1993-09-23 AT AT93115326T patent/ATE147720T1/de not_active IP Right Cessation
- 1993-09-23 LT LTIP1092A patent/LT3072B/lt not_active IP Right Cessation
- 1993-09-24 CO CO93410100A patent/CO4560549A1/es unknown
- 1993-09-24 ZA ZA937079A patent/ZA937079B/xx unknown
- 1993-09-24 TW TW082107871A patent/TW239117B/zh active
- 1993-09-24 MX MX9305918A patent/MX9305918A/es not_active IP Right Cessation
- 1993-09-25 CN CN93117983A patent/CN1090278A/zh active Pending
-
1994
- 1994-11-23 EE EE9400334A patent/EE03083B1/xx unknown
-
1995
- 1995-03-24 NO NO951133A patent/NO951133L/no unknown
- 1995-03-24 FI FI951398A patent/FI951398A0/fi not_active Application Discontinuation
- 1995-04-03 BG BG99542A patent/BG99542A/bg unknown
- 1995-04-25 LV LVP-95-107A patent/LV10945B/en unknown
- 1995-06-23 HU HU95P/P00428P patent/HU211315A9/hu unknown
-
1996
- 1996-02-01 US US08/595,327 patent/US5693619A/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0976748A4 (fr) | Derives de pyrrolidine ayant une activite inhibant la phospholipase a2 | |
| NO940737L (fr) | ||
| DE69332259D1 (de) | Kondensierte Thiadiazolderivate, Verfahren zu ihrer Herstellung und deren Verwendung | |
| IL107092A (en) | Renin inhibiting n-(2-amino- 2-oxoethyl) butanediamide derivatives, their preparation and pharmaceutical compositions containing them | |
| HU9201033D0 (en) | Tiazolidinone- and oxazolidinone derivatives, process for their production, and for the production of medical preparations containing them as active agents | |
| TW221429B (fr) | ||
| IL107093A0 (en) | N-(hydroxyethyl)butanediamide derivatives,their preparation and pharmaceutical compositions containing them | |
| AU657423B2 (en) | Novel piperidine derivatives and process for preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH | Patent void |