EE03083B1 - Reniini inhibeerivad N-(2-amino-2-oksüetüül)butaandiamiidi derivaadid, meetodid nende saamiseks ja neid sisaldav ravim - Google Patents
Reniini inhibeerivad N-(2-amino-2-oksüetüül)butaandiamiidi derivaadid, meetodid nende saamiseks ja neid sisaldav ravimInfo
- Publication number
- EE03083B1 EE03083B1 EE9400334A EE9400334A EE03083B1 EE 03083 B1 EE03083 B1 EE 03083B1 EE 9400334 A EE9400334 A EE 9400334A EE 9400334 A EE9400334 A EE 9400334A EE 03083 B1 EE03083 B1 EE 03083B1
- Authority
- EE
- Estonia
- Prior art keywords
- alkyl
- amino
- renin
- oxyethyl
- inhibiting
- Prior art date
Links
- 102100028255 Renin Human genes 0.000 title abstract 2
- 108090000783 Renin Proteins 0.000 title abstract 2
- SNCZNSNPXMPCGN-UHFFFAOYSA-N butanediamide Chemical class NC(=O)CCC(N)=O SNCZNSNPXMPCGN-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- -1 2-(2-pyridinyl)ethyl Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000003287 1H-imidazol-4-ylmethyl group Chemical group [H]N1C([H])=NC(C([H])([H])[*])=C1[H] 0.000 abstract 1
- 102000004881 Angiotensinogen Human genes 0.000 abstract 1
- 108090001067 Angiotensinogen Proteins 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000005505 thiomorpholino group Chemical group 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95147892A | 1992-09-25 | 1992-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE03083B1 true EE03083B1 (et) | 1998-04-15 |
Family
ID=25491725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9400334A EE03083B1 (et) | 1992-09-25 | 1994-11-23 | Reniini inhibeerivad N-(2-amino-2-oksüetüül)butaandiamiidi derivaadid, meetodid nende saamiseks ja neid sisaldav ravim |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5541163A (fr) |
| EP (1) | EP0589445B1 (fr) |
| JP (1) | JP3490442B2 (fr) |
| KR (1) | KR950703520A (fr) |
| CN (1) | CN1090278A (fr) |
| AT (1) | ATE147720T1 (fr) |
| AU (1) | AU680829B2 (fr) |
| BG (1) | BG99542A (fr) |
| BR (1) | BR9307110A (fr) |
| CA (1) | CA2143300C (fr) |
| CO (1) | CO4560549A1 (fr) |
| CZ (1) | CZ74895A3 (fr) |
| DE (1) | DE69307446T2 (fr) |
| EE (1) | EE03083B1 (fr) |
| FI (1) | FI951398A (fr) |
| HU (2) | HUT70432A (fr) |
| IL (1) | IL107092A (fr) |
| LT (1) | LT3072B (fr) |
| LV (1) | LV10945B (fr) |
| MX (1) | MX9305918A (fr) |
| NO (1) | NO951133L (fr) |
| NZ (1) | NZ255301A (fr) |
| PH (1) | PH30881A (fr) |
| PL (1) | PL174454B1 (fr) |
| RU (1) | RU95113586A (fr) |
| SK (1) | SK37695A3 (fr) |
| TW (1) | TW239117B (fr) |
| WO (1) | WO1994007846A1 (fr) |
| ZA (1) | ZA937079B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT70402A (en) * | 1992-09-25 | 1995-10-30 | Bio Mega Boehringer Ingelheim | N-(hydroxyethyl)butanediamide derivatives as renin inhibitors, pharmaceutical compns. contg. them and process to prepare the said compds. |
| CA2165996C (fr) * | 1995-12-22 | 2002-01-29 | Murray Douglas Bailey | Preparation stereoselective de composes de type succinique avec substitution en 2 |
| US6096759A (en) | 1997-09-19 | 2000-08-01 | Georgetown University | Method for treating essential hypertension |
| WO2005037317A2 (fr) * | 2003-10-17 | 2005-04-28 | Cornell Research Foundation, Inc. | Renine d'origine mastocytaire |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5006511A (en) * | 1981-10-14 | 1991-04-09 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa |
| EP0278158A3 (fr) | 1986-11-12 | 1990-05-23 | Merck & Co. Inc. | Inhibiteurs de rénine contenant des remplaçants de phénylalanyl-histidine |
| US4839357A (en) | 1987-10-02 | 1989-06-13 | Merck & Co., Inc. | Renin inhibitors containing phenylalanyl-histidine replacements |
| EP0312283A3 (fr) * | 1987-10-14 | 1990-05-09 | Merck & Co. Inc. | Inhibiteurs de la rénine di-ou tripeptidiques, contenant une restriction conformationnelle du type lactame dans ACHPA |
| US5001113A (en) | 1987-10-14 | 1991-03-19 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA |
| CA1329680C (fr) * | 1987-11-23 | 1994-05-17 | Harold Norris Weller, Iii | Derives d'un alcool n-heterocyclique |
| US5055466A (en) * | 1987-11-23 | 1991-10-08 | E. R. Squibb & Sons, Inc. | N-morpholino derivatives and their use as anti-hypertensive agents |
| NO892728L (no) * | 1988-07-01 | 1990-01-02 | Searle & Co | Aminoalkyl-aminokarbonyl-aminodiolaminosyre derivater somanti-hypertensive midler. |
| US5063208A (en) * | 1989-07-26 | 1991-11-05 | Abbott Laboratories | Peptidyl aminodiol renin inhibitors |
| IE902446A1 (en) * | 1989-07-26 | 1991-02-13 | Abbott Lab | Peptidyl aminodiol renin inhibitors |
| ES2086341T3 (es) * | 1989-09-12 | 1996-07-01 | Hoechst Ag | Derivados de aminoacidos con propiedades inhibidoras de la renina, procedimiento para su preparacion, agentes que los contienen y su utilizacion. |
| JPH0532602A (ja) * | 1991-07-26 | 1993-02-09 | Terumo Corp | ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤 |
-
1993
- 1993-09-15 NZ NZ255301A patent/NZ255301A/en unknown
- 1993-09-15 SK SK376-95A patent/SK37695A3/sk unknown
- 1993-09-15 PL PL93308180A patent/PL174454B1/pl unknown
- 1993-09-15 WO PCT/CA1993/000380 patent/WO1994007846A1/fr not_active Application Discontinuation
- 1993-09-15 CA CA002143300A patent/CA2143300C/fr not_active Expired - Fee Related
- 1993-09-15 BR BR9307110A patent/BR9307110A/pt not_active Application Discontinuation
- 1993-09-15 RU RU95113586/04A patent/RU95113586A/ru unknown
- 1993-09-15 AU AU49403/93A patent/AU680829B2/en not_active Ceased
- 1993-09-15 HU HU9500871A patent/HUT70432A/hu unknown
- 1993-09-15 JP JP50854294A patent/JP3490442B2/ja not_active Expired - Fee Related
- 1993-09-15 KR KR1019950701149A patent/KR950703520A/ko not_active Application Discontinuation
- 1993-09-15 CZ CZ95748A patent/CZ74895A3/cs unknown
- 1993-09-17 US US08/122,280 patent/US5541163A/en not_active Expired - Lifetime
- 1993-09-23 DE DE69307446T patent/DE69307446T2/de not_active Expired - Lifetime
- 1993-09-23 EP EP93115326A patent/EP0589445B1/fr not_active Expired - Lifetime
- 1993-09-23 LT LTIP1092A patent/LT3072B/lt not_active IP Right Cessation
- 1993-09-23 IL IL107092A patent/IL107092A/xx not_active IP Right Cessation
- 1993-09-23 AT AT93115326T patent/ATE147720T1/de not_active IP Right Cessation
- 1993-09-23 PH PH46946A patent/PH30881A/en unknown
- 1993-09-24 CO CO93410100A patent/CO4560549A1/es unknown
- 1993-09-24 ZA ZA937079A patent/ZA937079B/xx unknown
- 1993-09-24 MX MX9305918A patent/MX9305918A/es not_active IP Right Cessation
- 1993-09-24 TW TW082107871A patent/TW239117B/zh active
- 1993-09-25 CN CN93117983A patent/CN1090278A/zh active Pending
-
1994
- 1994-11-23 EE EE9400334A patent/EE03083B1/xx unknown
-
1995
- 1995-03-24 FI FI951398A patent/FI951398A/fi not_active Application Discontinuation
- 1995-03-24 NO NO951133A patent/NO951133L/no unknown
- 1995-04-03 BG BG99542A patent/BG99542A/bg unknown
- 1995-04-25 LV LVP-95-107A patent/LV10945B/en unknown
- 1995-06-23 HU HU95P/P00428P patent/HU211315A9/hu unknown
-
1996
- 1996-02-01 US US08/595,327 patent/US5693619A/en not_active Expired - Lifetime
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