IL106076A - A mixture of 3,5-bit (protected hydroxy) sulfonate basket mixture - 2-dioxy-2,2 difluoro-D ribopornosyl-1-alkyl- (or aryl) -enriched with alpha anomer and a low-temperature process for their preparation - Google Patents

A mixture of 3,5-bit (protected hydroxy) sulfonate basket mixture - 2-dioxy-2,2 difluoro-D ribopornosyl-1-alkyl- (or aryl) -enriched with alpha anomer and a low-temperature process for their preparation

Info

Publication number
IL106076A
IL106076A IL10607693A IL10607693A IL106076A IL 106076 A IL106076 A IL 106076A IL 10607693 A IL10607693 A IL 10607693A IL 10607693 A IL10607693 A IL 10607693A IL 106076 A IL106076 A IL 106076A
Authority
IL
Israel
Prior art keywords
substituted
group
ribofuranosyl
sulfonating
deoxy
Prior art date
Application number
IL10607693A
Other languages
English (en)
Hebrew (he)
Other versions
IL106076A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25415642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL106076(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL106076A0 publication Critical patent/IL106076A0/xx
Publication of IL106076A publication Critical patent/IL106076A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL10607693A 1992-06-22 1993-06-21 A mixture of 3,5-bit (protected hydroxy) sulfonate basket mixture - 2-dioxy-2,2 difluoro-D ribopornosyl-1-alkyl- (or aryl) -enriched with alpha anomer and a low-temperature process for their preparation IL106076A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,301 US5401861A (en) 1992-06-22 1992-06-22 Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Publications (2)

Publication Number Publication Date
IL106076A0 IL106076A0 (en) 1993-10-20
IL106076A true IL106076A (en) 2002-02-10

Family

ID=25415642

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10607693A IL106076A (en) 1992-06-22 1993-06-21 A mixture of 3,5-bit (protected hydroxy) sulfonate basket mixture - 2-dioxy-2,2 difluoro-D ribopornosyl-1-alkyl- (or aryl) -enriched with alpha anomer and a low-temperature process for their preparation

Country Status (15)

Country Link
US (1) US5401861A (hu)
EP (1) EP0576229B1 (hu)
JP (1) JP3379994B2 (hu)
KR (1) KR100312389B1 (hu)
AT (1) ATE161264T1 (hu)
BR (1) BR9302428A (hu)
CA (1) CA2098886C (hu)
DE (1) DE69315752T2 (hu)
DK (1) DK0576229T3 (hu)
ES (1) ES2112389T3 (hu)
GR (1) GR3026210T3 (hu)
HU (1) HU216840B (hu)
IL (1) IL106076A (hu)
MX (1) MX9303710A (hu)
TW (1) TW233299B (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CA2410579C (en) 2000-05-26 2010-04-20 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses
RS113904A (en) * 2002-06-28 2007-02-05 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
CN1849142A (zh) * 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′－支链核苷和黄病毒突变
JP5116972B2 (ja) * 2002-12-12 2013-01-09 イデニクス（ケイマン）リミテツド ２’−分枝ヌクレオシドの製造方法
JP2008503562A (ja) * 2004-06-23 2008-02-07 イデニクス（ケイマン）リミテツド フラビウイルス科による感染症を治療するための５−アザ−７−デアザプリン誘導体
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
KR100578616B1 (ko) * 2004-07-23 2006-05-10 한미약품 주식회사 Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
WO2006011713A1 (en) 2004-07-29 2006-02-02 Hanmi Pharm. Co., Ltd. 1-α-HALO-2,2-DIFLUORO-2-DEOXY-D-RIBOFURANOSE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
WO2006070985A1 (en) 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
WO2006071090A1 (en) * 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. Method for the preparation of 2'-deoxy-2',2'-difluorocytidine
EP1853616B1 (en) * 2005-03-04 2010-02-24 Fresenius Kabi Oncology Limited Intermediate and process for preparing of beta-anomer enriched 2'-deoxy,2',2'-difluoro-d-ribofuranosyl nucleosides
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
CN101203525B (zh) * 2005-06-03 2012-06-13 台湾神隆股份有限公司 制备α-端基异构体富集的2-脱氧-2,2-二氟-D-呋喃核糖基磺酸酯的方法及其制备β核苷的应用
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
JP5254033B2 (ja) * 2005-12-23 2013-08-07 イデニク プハルマセウティカルス，インコーポレイテッド 分岐型ヌクレオシドを調製するための合成中間体の製造方法
KR101357409B1 (ko) 2006-11-03 2014-02-03 에스티팜 주식회사 2′-데옥시-2′,2′-디플루오로시티딘의 제조방법
KR100858842B1 (ko) 2007-03-23 2008-09-22 동우신테크 주식회사 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법
US7994310B2 (en) * 2007-03-23 2011-08-09 Dongwoo Syntech Co., Ltd. Process for preparing 2′-deoxy-2′, 2′-difluorocytidine
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
CN109796506A (zh) * 2019-01-28 2019-05-24 江苏八巨药业有限公司 一种吉西他滨关键中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
IL87517A (en) * 1987-08-28 1993-05-13 Lilly Co Eli Process for preparing an enantiomeric mixture of erythro and threo lactones

Also Published As

Publication number Publication date
HU216840B (hu) 1999-09-28
MX9303710A (es) 1994-01-31
IL106076A0 (en) 1993-10-20
DE69315752T2 (de) 1998-04-23
EP0576229A1 (en) 1993-12-29
JPH0656866A (ja) 1994-03-01
HUT64552A (en) 1994-01-28
JP3379994B2 (ja) 2003-02-24
HU9301827D0 (en) 1993-09-28
ES2112389T3 (es) 1998-04-01
CA2098886A1 (en) 1993-12-23
DE69315752D1 (de) 1998-01-29
EP0576229B1 (en) 1997-12-17
KR940005655A (ko) 1994-03-22
TW233299B (hu) 1994-11-01
US5401861A (en) 1995-03-28
ATE161264T1 (de) 1998-01-15
GR3026210T3 (en) 1998-05-29
CA2098886C (en) 2005-08-09
BR9302428A (pt) 1994-01-11
KR100312389B1 (ko) 2002-06-20
DK0576229T3 (da) 1998-01-19

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