IL106073A0 - 2'-deoxy-2',2'-difluoro(2,6,8-substituted)purine nucleosides having anti-viral and anti-cancer activity and intermediates - Google Patents

2'-deoxy-2',2'-difluoro(2,6,8-substituted)purine nucleosides having anti-viral and anti-cancer activity and intermediates

Info

Publication number
IL106073A0
IL106073A0 IL106073A IL10607393A IL106073A0 IL 106073 A0 IL106073 A0 IL 106073A0 IL 106073 A IL106073 A IL 106073A IL 10607393 A IL10607393 A IL 10607393A IL 106073 A0 IL106073 A0 IL 106073A0
Authority
IL
Israel
Prior art keywords
deoxy
difluoro
intermediates
viral
substituted
Prior art date
Application number
IL106073A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL106073A0 publication Critical patent/IL106073A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IL106073A 1992-06-22 1993-06-21 2'-deoxy-2',2'-difluoro(2,6,8-substituted)purine nucleosides having anti-viral and anti-cancer activity and intermediates IL106073A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90230492A 1992-06-22 1992-06-22

Publications (1)

Publication Number Publication Date
IL106073A0 true IL106073A0 (en) 1993-10-20

Family

ID=25415652

Family Applications (1)

Application Number Title Priority Date Filing Date
IL106073A IL106073A0 (en) 1992-06-22 1993-06-21 2'-deoxy-2',2'-difluoro(2,6,8-substituted)purine nucleosides having anti-viral and anti-cancer activity and intermediates

Country Status (14)

Country Link
EP (1) EP0576227A3 (es)
JP (1) JPH0656877A (es)
KR (1) KR940005656A (es)
CN (1) CN1084178A (es)
AU (1) AU4134793A (es)
BR (1) BR9302433A (es)
CA (1) CA2098876A1 (es)
CZ (1) CZ123293A3 (es)
FI (1) FI932868A (es)
HU (1) HUT64553A (es)
IL (1) IL106073A0 (es)
MX (1) MX9303709A (es)
NO (1) NO932287L (es)
PL (1) PL299412A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
JP2001501580A (ja) * 1996-01-23 2001-02-06 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 抗ウイルス剤としての修飾ベンズイミダゾールヌクレオシド
ATE271063T1 (de) * 1996-10-16 2004-07-15 Icn Pharmaceuticals Purin-l-nukleoside, deren analoga und verwendungen
TW466112B (en) * 1998-04-14 2001-12-01 Lilly Co Eli Novel use of 2'-deoxy-2',2'-difluorocytidine for immunosuppressive therapy and pharmaceutical composition comprising the same
WO2003062256A1 (en) * 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
CN1293884C (zh) * 2002-10-29 2007-01-10 南京长澳医药科技有限公司 6－甲氧基双脱氧鸟苷在制备抗乙肝药物中的应用
JP5002851B2 (ja) * 2005-01-20 2012-08-15 独立行政法人理化学研究所 イミダゾピリジン誘導体
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
AT502635A1 (de) * 2005-11-09 2007-05-15 Saischek Und Partner Meg Neue 1,3-dithioverbindungen, verfahren zu deren herstellung und ihre verwendung
CN101557725B (zh) * 2006-12-13 2013-09-18 奇华顿荷兰服务有限责任公司 羧酸和嘌呤、嘧啶、核苷或核苷酸的风味调节衍生物
MX2009005879A (es) 2006-12-13 2009-09-09 Givaudan Nederland Services B Derivado modulador del sabor de un acido carboxilico y una purina, pirimidina, nucleosido o nucleotido.
CN106317147B (zh) * 2015-07-06 2018-11-27 扬州硒瑞恩生物医药科技有限公司 核苷类化合物及其制备方法
WO2018110643A1 (ja) * 2016-12-14 2018-06-21 ヤマサ醤油株式会社 抗ウイルス活性を示すヌクレオシド誘導体
WO2018181102A1 (ja) * 2017-03-29 2018-10-04 ヤマサ醤油株式会社 ヌクレオシド誘導体又はその塩、及びそれを含む医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77133A (en) * 1984-12-04 1991-01-31 Lilly Co Eli Antineoplastic pharmaceutical compositions containing pentofuranoside derivatives,some new such compounds and their preparation
CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents
US4914028A (en) * 1988-02-10 1990-04-03 Eli Lilly And Company Method of preparing beta-2',2'-difluoronucleosides
IL89258A0 (en) * 1988-02-16 1989-09-10 Lilly Co Eli 2',3'-dideoxy-2',2'-difluoro-nucleosides

Also Published As

Publication number Publication date
CA2098876A1 (en) 1993-12-23
KR940005656A (ko) 1994-03-22
HU9301821D0 (en) 1993-09-28
JPH0656877A (ja) 1994-03-01
NO932287D0 (no) 1993-06-21
BR9302433A (pt) 1994-01-11
EP0576227A2 (en) 1993-12-29
HUT64553A (en) 1994-01-28
AU4134793A (en) 1993-12-23
FI932868A0 (fi) 1993-06-21
CN1084178A (zh) 1994-03-23
EP0576227A3 (en) 1994-02-09
CZ123293A3 (en) 1994-03-16
NO932287L (no) 1993-12-23
MX9303709A (es) 1994-05-31
FI932868A (fi) 1993-12-23
PL299412A1 (en) 1993-12-27

Similar Documents

Publication Publication Date Title
GR3020064T3 (en) 2'-deoxy-2', 2'-difluoro(4-substituted pyrimidine) nucleosides having antiviral and anti-cancer activity and intermediates
GR3021389T3 (en) Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
HK85789A (en) Antiviral nucleosides
CY2186B1 (en) Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neuraminic acid and their use as antiviral agents
EP0219829A3 (en) 2-fluoro-arabinofuranosyl purine nucleosides
IL106073A0 (en) 2'-deoxy-2',2'-difluoro(2,6,8-substituted)purine nucleosides having anti-viral and anti-cancer activity and intermediates
ZA898567B (en) Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives
GB9218810D0 (en) Antiviral pyrimidine nucleosides
NZ227663A (en) Purine nucleoside analogues, pyrimidine derivatives and pharmaceutical compositions
EP0409227A3 (en) Pyrimidine and purine nucleosides, their preparation and use as medicaments
IE900275L (en) Antivirals and methods of increasing the antiviral activity¹of azt
NZ235534A (en) 3'-azido-2',3'-dideoxy purine derivatives
IL91773A0 (en) 2'haloethylidene,2'-ethenylidene and 2'-ethynyl adenosine derivatives
AU633065B2 (en) 3'-substituted methyl nucleosides as antiviral agents
DE3664257D1 (en) Antiviral nucleosides
GB8902041D0 (en) Antiviral agent and novel nucleoside
ZA861933B (en) Antiviral nucleosides
EP0353268A4 (en) ANTI-TUMOR PURINES OF 6-SULFENAMIDE, 6-SULFINAMIDE AND 6-SULFONAMIDE, PURINE NUCLEOSIDES, PURINE NUCLEOTIDES AND RELATED COMPOUNDS.
ZA902631B (en) 3'-substituted methyl nucleosides as antiviral agents
ZA905616B (en) Antiviral pyrimidine nucleosides
ZA907938B (en) Further antiviral pyrimidine nucleosides
GB8816117D0 (en) Antiviral nucleosides
GB9218812D0 (en) Further antiviral pyrimidine nucleosides
ZA878607B (en) Antiviral phosphonomethyoxyalkylene purine and pyrmadine derivatives
GB9318282D0 (en) Further antiviral pyrimidine nucleosides