IL105669A - Hydroxyethylene isosteres-3-peptides containing diethylnilglycin, their preparation and VIH protease inhibitors containing them - Google Patents

Hydroxyethylene isosteres-3-peptides containing diethylnilglycin, their preparation and VIH protease inhibitors containing them

Info

Publication number
IL105669A
IL105669A IL105669A IL10566993A IL105669A IL 105669 A IL105669 A IL 105669A IL 105669 A IL105669 A IL 105669A IL 10566993 A IL10566993 A IL 10566993A IL 105669 A IL105669 A IL 105669A
Authority
IL
Israel
Prior art keywords
denotes
carbon atoms
compounds
general formula
group
Prior art date
Application number
IL105669A
Other languages
English (en)
Hebrew (he)
Other versions
IL105669A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL105669A0 publication Critical patent/IL105669A0/xx
Publication of IL105669A publication Critical patent/IL105669A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
IL105669A 1992-05-14 1993-05-11 Hydroxyethylene isosteres-3-peptides containing diethylnilglycin, their preparation and VIH protease inhibitors containing them IL105669A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4215874A DE4215874A1 (de) 1992-05-14 1992-05-14 Dithiolanylglycinhaltige HIV-Proteaseinhibitoren vom Hydroxyethylenisostertyp

Publications (2)

Publication Number Publication Date
IL105669A0 IL105669A0 (en) 1993-09-22
IL105669A true IL105669A (en) 1998-02-22

Family

ID=6458834

Family Applications (1)

Application Number Title Priority Date Filing Date
IL105669A IL105669A (en) 1992-05-14 1993-05-11 Hydroxyethylene isosteres-3-peptides containing diethylnilglycin, their preparation and VIH protease inhibitors containing them

Country Status (16)

Country Link
US (1) US5424426A (zh)
EP (1) EP0569811B1 (zh)
JP (1) JPH069628A (zh)
KR (1) KR930023363A (zh)
AT (1) ATE158304T1 (zh)
AU (1) AU666532B2 (zh)
CA (1) CA2095968A1 (zh)
DE (2) DE4215874A1 (zh)
DK (1) DK0569811T3 (zh)
ES (1) ES2107578T3 (zh)
GR (1) GR3025478T3 (zh)
HU (1) HUT65911A (zh)
IL (1) IL105669A (zh)
NZ (1) NZ247608A (zh)
TW (1) TW265347B (zh)
ZA (1) ZA933336B (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
WO1993018006A1 (en) 1992-03-11 1993-09-16 Narhex Limited Amine derivatives of oxo- and hydroxy-substitued hydrocarbons
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
AU2001259817A1 (en) * 2000-05-04 2001-11-12 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Methods of and compounds for inhibiting calpains
JP3756133B2 (ja) 2002-07-29 2006-03-15 旭化成ケミカルズ株式会社 グラフト共重合体およびその樹脂組成物
CA2580238A1 (en) * 2004-09-17 2006-03-30 Comentis, Inc. Bicyclic compounds which inhibit beta-secretase activity and methods of use thereof
JP2008535863A (ja) 2005-04-08 2008-09-04 コメンティス，インコーポレーテッド β−セクレターゼ活性を阻害する化合物およびその使用方法
KR20100051668A (ko) * 2007-07-26 2010-05-17 코멘티스, 인코포레이티드 베타-세크레타제 활성을 억제하는 이소프탈아미드 유도체

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
EP0357332A3 (en) * 1988-08-24 1991-07-31 Merck & Co. Inc. Renin inhibitors useful for the treatment of aids by inhibition of hiv protease
DE59009945D1 (de) * 1989-02-10 1996-01-18 Wolfgang Prof Dr Schramm Mittel zur hemmung von hiv-proteasen.
AU5407190A (en) * 1989-04-18 1990-11-16 Upjohn Company, The Peptides having novel polar n-terminal groups
DE3912829A1 (de) * 1989-04-19 1990-10-25 Bayer Ag Verwendung von renininhibitorischen peptiden als mittel gegen retroviren
DE4004820A1 (de) * 1989-08-05 1991-04-25 Bayer Ag Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE3939747A1 (de) * 1989-06-09 1990-12-13 Bayer Ag Renininhibitorische peptide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
WO1991006561A1 (en) * 1989-10-27 1991-05-16 The Upjohn Company Method for treating hiv and other retroviruses and compounds useful therefor
GB8927872D0 (en) * 1989-12-08 1990-02-14 Beecham Group Plc Pharmaceuticals
DE3941235A1 (de) * 1989-12-14 1991-06-20 Bayer Ag Neue peptide, ihre herstellung und ihre verwendung in arzneimitteln
CA2032259A1 (en) * 1989-12-18 1991-06-19 Wayne J. Thompson Hiv protease inhibitors useful for the treatment of aids
EP0594586A4 (en) * 1990-01-09 1994-08-17 Smithkline Beecham Corp Hiv protease inhibitors
DE4001236A1 (de) * 1990-01-18 1991-07-25 Bayer Ag Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren
EP0438311A3 (en) * 1990-01-19 1992-07-01 Merck & Co. Inc. Di- and tripeptide renin inhibitors
DE4004898A1 (de) * 1990-02-16 1991-08-22 Merck Patent Gmbh Peptid-analoga
CA2036413C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors
CA2036397C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors containing derived amino acid units
CA2036398C (en) * 1990-02-23 2000-06-13 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Hiv protease inhibiting agents
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
AU7732691A (en) * 1990-06-01 1991-12-05 Ciba-Geigy Ag Hiv protease inhibitors and processes for their preparation
DE4038947A1 (de) * 1990-12-06 1992-06-11 Bayer Ag Dithiolano- und dithianoglycin-haltige renininhibitorische peptide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4038921A1 (de) * 1990-12-06 1992-06-11 Bayer Ag Renininhibitorische peptide vom cyclohexylstatin-typ, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
NZ247608A (en) 1995-01-27
ES2107578T3 (es) 1997-12-01
HUT65911A (en) 1994-07-28
GR3025478T3 (en) 1998-02-27
CA2095968A1 (en) 1993-11-15
EP0569811A1 (de) 1993-11-18
US5424426A (en) 1995-06-13
AU3716093A (en) 1993-11-18
AU666532B2 (en) 1996-02-15
DE59307366D1 (de) 1997-10-23
HU9301388D0 (en) 1993-09-28
EP0569811B1 (de) 1997-09-17
KR930023363A (ko) 1993-12-18
TW265347B (zh) 1995-12-11
DK0569811T3 (da) 1998-05-04
JPH069628A (ja) 1994-01-18
ATE158304T1 (de) 1997-10-15
IL105669A0 (en) 1993-09-22
DE4215874A1 (de) 1993-11-18
ZA933336B (en) 1993-12-07

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Legal Events

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