DK0569811T3 - Dithiolanylglycinholdige HIV-proteaseinhibitorer af hydroxyethylenisostertypen - Google Patents

Dithiolanylglycinholdige HIV-proteaseinhibitorer af hydroxyethylenisostertypen

Info

Publication number
DK0569811T3
DK0569811T3 DK93107140.1T DK93107140T DK0569811T3 DK 0569811 T3 DK0569811 T3 DK 0569811T3 DK 93107140 T DK93107140 T DK 93107140T DK 0569811 T3 DK0569811 T3 DK 0569811T3
Authority
DK
Denmark
Prior art keywords
dithiolanylglycine
protease inhibitors
hiv protease
isoster
type hiv
Prior art date
Application number
DK93107140.1T
Other languages
English (en)
Inventor
Arnold Dr Paessens
Jutta Dr Hansen
Dieter Dr Haebich
Wolfgang Dr Bender
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK0569811T3 publication Critical patent/DK0569811T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK93107140.1T 1992-05-14 1993-05-03 Dithiolanylglycinholdige HIV-proteaseinhibitorer af hydroxyethylenisostertypen DK0569811T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4215874A DE4215874A1 (de) 1992-05-14 1992-05-14 Dithiolanylglycinhaltige HIV-Proteaseinhibitoren vom Hydroxyethylenisostertyp

Publications (1)

Publication Number Publication Date
DK0569811T3 true DK0569811T3 (da) 1998-05-04

Family

ID=6458834

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93107140.1T DK0569811T3 (da) 1992-05-14 1993-05-03 Dithiolanylglycinholdige HIV-proteaseinhibitorer af hydroxyethylenisostertypen

Country Status (16)

Country Link
US (1) US5424426A (da)
EP (1) EP0569811B1 (da)
JP (1) JPH069628A (da)
KR (1) KR930023363A (da)
AT (1) ATE158304T1 (da)
AU (1) AU666532B2 (da)
CA (1) CA2095968A1 (da)
DE (2) DE4215874A1 (da)
DK (1) DK0569811T3 (da)
ES (1) ES2107578T3 (da)
GR (1) GR3025478T3 (da)
HU (1) HUT65911A (da)
IL (1) IL105669A (da)
NZ (1) NZ247608A (da)
TW (1) TW265347B (da)
ZA (1) ZA933336B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
ATE253050T1 (de) 1992-03-11 2003-11-15 Narhex Ltd Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
RU2126794C1 (ru) 1992-03-11 1999-02-27 Нархекс Лимитед Аминопроизводные оксо- или гидроксизамещенных гидразинов, способ их получения и фармацевтические композиции для ингибирования ретровирусной протеазы
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
AU2001259817A1 (en) * 2000-05-04 2001-11-12 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Methods of and compounds for inhibiting calpains
JP3756133B2 (ja) 2002-07-29 2006-03-15 旭化成ケミカルズ株式会社 グラフト共重合体およびその樹脂組成物
CA2580238A1 (en) * 2004-09-17 2006-03-30 Comentis, Inc. Bicyclic compounds which inhibit beta-secretase activity and methods of use thereof
BRPI0607019A2 (pt) 2005-04-08 2009-07-28 Univ Illinois compostos que inibem a atividade de beta -secretase e métodos de uso dos mesmos
MX2010000956A (es) * 2007-07-26 2010-03-01 Comentis Inc Derivados de isoftalamida que inhiben actividad de beta-secretasa.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
EP0357332A3 (en) * 1988-08-24 1991-07-31 Merck & Co. Inc. Renin inhibitors useful for the treatment of aids by inhibition of hiv protease
EP0409962B1 (de) * 1989-02-10 1995-12-06 SCHRAMM, Wolfgang Mittel zur hemmung von hiv-proteasen
EP0468998A1 (en) * 1989-04-18 1992-02-05 The Upjohn Company Peptides having novel polar n-terminal groups
DE3912829A1 (de) * 1989-04-19 1990-10-25 Bayer Ag Verwendung von renininhibitorischen peptiden als mittel gegen retroviren
DE4004820A1 (de) * 1989-08-05 1991-04-25 Bayer Ag Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE3939747A1 (de) * 1989-06-09 1990-12-13 Bayer Ag Renininhibitorische peptide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
AU6633490A (en) * 1989-10-27 1991-05-31 Upjohn Company, The Method for treating hiv and other retroviruses and compounds useful therefor
GB8927872D0 (en) * 1989-12-08 1990-02-14 Beecham Group Plc Pharmaceuticals
DE3941235A1 (de) * 1989-12-14 1991-06-20 Bayer Ag Neue peptide, ihre herstellung und ihre verwendung in arzneimitteln
CA2032259A1 (en) * 1989-12-18 1991-06-19 Wayne J. Thompson Hiv protease inhibitors useful for the treatment of aids
JPH05503703A (ja) * 1990-01-09 1993-06-17 スミスクライン・ビーチャム・コーポレイション Ｈｉｖプロテアーゼ抑制剤
DE4001236A1 (de) * 1990-01-18 1991-07-25 Bayer Ag Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren
EP0438311A3 (en) * 1990-01-19 1992-07-01 Merck & Co. Inc. Di- and tripeptide renin inhibitors
DE4004898A1 (de) * 1990-02-16 1991-08-22 Merck Patent Gmbh Peptid-analoga
CA2036413C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors
CA2036398C (en) * 1990-02-23 2000-06-13 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Hiv protease inhibiting agents
CA2036397C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors containing derived amino acid units
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
AU7732691A (en) * 1990-06-01 1991-12-05 Ciba-Geigy Ag Hiv protease inhibitors and processes for their preparation
DE4038921A1 (de) * 1990-12-06 1992-06-11 Bayer Ag Renininhibitorische peptide vom cyclohexylstatin-typ, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4038947A1 (de) * 1990-12-06 1992-06-11 Bayer Ag Dithiolano- und dithianoglycin-haltige renininhibitorische peptide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
ZA933336B (en) 1993-12-07
CA2095968A1 (en) 1993-11-15
IL105669A (en) 1998-02-22
AU666532B2 (en) 1996-02-15
AU3716093A (en) 1993-11-18
HUT65911A (en) 1994-07-28
US5424426A (en) 1995-06-13
EP0569811A1 (de) 1993-11-18
ATE158304T1 (de) 1997-10-15
ES2107578T3 (es) 1997-12-01
KR930023363A (ko) 1993-12-18
DE4215874A1 (de) 1993-11-18
IL105669A0 (en) 1993-09-22
JPH069628A (ja) 1994-01-18
HU9301388D0 (en) 1993-09-28
GR3025478T3 (en) 1998-02-27
DE59307366D1 (de) 1997-10-23
NZ247608A (en) 1995-01-27
TW265347B (da) 1995-12-11
EP0569811B1 (de) 1997-09-17

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