IL105223A0 - Cyclohexane-ylidenes and pharmaceutical compositions containing them - Google Patents
Cyclohexane-ylidenes and pharmaceutical compositions containing themInfo
- Publication number
- IL105223A0 IL105223A0 IL10522393A IL10522393A IL105223A0 IL 105223 A0 IL105223 A0 IL 105223A0 IL 10522393 A IL10522393 A IL 10522393A IL 10522393 A IL10522393 A IL 10522393A IL 105223 A0 IL105223 A0 IL 105223A0
- Authority
- IL
- Israel
- Prior art keywords
- ylidenes
- cyclohexane
- pharmaceutical compositions
- compositions containing
- pharmaceutical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86211292A | 1992-04-02 | 1992-04-02 | |
US96876092A | 1992-10-30 | 1992-10-30 | |
PCT/US1993/001988 WO1993019747A1 (en) | 1992-04-02 | 1993-03-05 | Compounds useful for treating allergic and inflammatory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
IL105223A0 true IL105223A0 (en) | 1994-08-26 |
Family
ID=27127669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10522393A IL105223A0 (en) | 1992-04-02 | 1993-03-30 | Cyclohexane-ylidenes and pharmaceutical compositions containing them |
Country Status (10)
Country | Link |
---|---|
US (1) | US5602173A (xx) |
EP (1) | EP0634930A4 (xx) |
JP (1) | JP3195352B2 (xx) |
CN (1) | CN1094711A (xx) |
AU (1) | AU3738293A (xx) |
IL (1) | IL105223A0 (xx) |
MA (1) | MA22923A1 (xx) |
MX (1) | MX9301903A (xx) |
SI (1) | SI9300170A (xx) |
WO (1) | WO1993019747A1 (xx) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE240290T1 (de) * | 1992-04-02 | 2003-05-15 | Smithkline Beecham Corp | Verbindungen verwendbar für die behandlung von allergien und entzündungskrankheiten |
GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
US5646156A (en) * | 1994-04-25 | 1997-07-08 | Merck & Co., Inc. | Inhibition of eosinophil activation through A3 adenosine receptor antagonism |
US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
US5591776A (en) | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
US5578576A (en) * | 1994-09-02 | 1996-11-26 | Dalhousie University | Method and composition for treating intestinal wounds or ulcers |
WO1996018399A1 (en) * | 1994-12-13 | 1996-06-20 | Euro-Celtique, S.A. | Aryl thioxanthines |
WO1996019979A1 (en) * | 1994-12-23 | 1996-07-04 | Smithkline Beecham Corporation | 1,4,4-(trisubstituted)cyclohexane dimers and related compounds |
JPH10511387A (ja) * | 1994-12-23 | 1998-11-04 | スミスクライン・ビーチャム・コーポレイション | 1,3,3−(三置換)シクロヘキサンダイマーおよび関連化合物 |
EP0794773A4 (en) * | 1994-12-23 | 1998-04-29 | Smithkline Beecham Corp | 1,4,4- (TRISUBSTITUTE) CYCLOHEXANE MONOMERS AND RELATED COMPOUNDS |
JPH11505236A (ja) * | 1995-05-18 | 1999-05-18 | ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング | フェニルジヒドロベンゾフラン |
EP0828727B1 (de) * | 1995-05-18 | 2003-01-02 | ALTANA Pharma AG | Cyclohexyldihydrobenzofurane |
US6268373B1 (en) | 1995-06-07 | 2001-07-31 | Euro-Celtique S.A. | Trisubstituted thioxanthines |
US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
US5891883A (en) * | 1995-12-21 | 1999-04-06 | Smithkline Beecham Corporation | 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds |
US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
US5744473A (en) * | 1996-09-16 | 1998-04-28 | Euro-Celtique, S.A. | PDE IV inhibitors: "bis-compounds" |
AR012550A1 (es) * | 1997-02-12 | 2000-11-08 | Smithkline Beecham Corp | Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos y compuestos intermediarios |
EP1295869B1 (en) * | 1997-02-12 | 2005-07-27 | SmithKline Beecham Corporation | Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids |
EP1524268B1 (en) * | 1997-02-12 | 2007-01-17 | Smithkline Beecham Corporation | Compounds and method for preparing sustituted 4-phenyl-4-cyanocyclohexanoic acids |
US20040220424A1 (en) * | 1999-08-06 | 2004-11-04 | Smithkline Beecham Corporation | Process for preparing acids via alpha-chloroepoxy esters |
ECSP003599A (es) * | 1999-08-06 | 2002-03-25 | Smithkline Beecham Corp | Procedimiento para preparar acidos a traves de alfa-coroepoxi-esteres |
SI1212089T1 (sl) | 1999-08-21 | 2006-08-31 | Altana Pharma Ag | Sinergisticna kombinacija roflumilasta in salmeterola |
CA2402384A1 (en) * | 2000-03-16 | 2001-09-20 | Inflazyme Pharmaceuticals Ltd. | Benzylated pde4 inhibitors |
NZ524050A (en) * | 2000-08-11 | 2005-07-29 | Ono Pharmaceutical Co | Piperidine derivatives in compounds that have a PDE4 inhibitory activity to treat inflammatory conditions |
US7425567B2 (en) * | 2002-02-08 | 2008-09-16 | Ono Pharmaceutical Co., Ltd. | Piperidine derivative compounds and drugs containing the compounds as the active ingredient |
TW200302724A (en) * | 2002-02-08 | 2003-08-16 | Ono Pharmaceutical Co | Piperiding derivative compound and pharmaceuticals containing same as active ingredient |
AU2003253130A1 (en) * | 2002-08-19 | 2004-03-03 | Glenmark Pharmaceuticals Limited | Condensed heterocyclic compounds as pde-iv inhibitors for the treatment of inflammatory and allergic disorders |
JP2006506379A (ja) | 2002-10-23 | 2006-02-23 | グレンマーク・ファーマシューティカルズ・リミテッド | 炎症性およびアレルギー性疾患の治療に有用な新規三環式化合物:その調製方法およびそれらを含む医薬組成物 |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
JP2006522151A (ja) | 2003-04-01 | 2006-09-28 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 不妊症におけるホスホジエステラーゼ阻害剤 |
PT1620429E (pt) | 2003-04-11 | 2009-04-28 | Glenmark Pharmaceuticals Sa | Novos compostos heterocíclicos úteis para o tratamento de perturbações inflamatórias e alérgicas: processo para a sua preparação e composições farmacêuticas que os contêm |
US20050026883A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
US20050085430A1 (en) * | 2003-07-31 | 2005-04-21 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
US20090274676A1 (en) * | 2003-07-31 | 2009-11-05 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
CA2583497A1 (en) | 2004-10-13 | 2006-04-20 | Glenmark Pharmaceuticals S.A. | Process for the preparation of n-(3,5-dichloropyrid-4-yl)-4difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide |
UA88795C2 (ru) | 2004-12-17 | 2009-11-25 | Гленмарк Фармасьютікалс С.А. | Гетероциклические соединения, которые применяются для лечения воспалителных и аллергических нарушений |
AP2334A (en) | 2004-12-17 | 2011-12-06 | Glenmark Pharmaceuticals Sa | Novel heterocyclic compounds useful for the treatment of inflamatory and allergic disorders. |
EA020466B1 (ru) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EA201391254A1 (ru) | 2011-03-01 | 2014-02-28 | Синерджи Фармасьютикалз Инк. | Способ получения агонистов гуанилатциклазы c |
EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
PT3004138T (pt) | 2013-06-05 | 2024-06-18 | Bausch Health Ireland Ltd | Agonistas ultrapuros de guanilato ciclase c, método de produção e utilização dos mesmos |
AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
-
1993
- 1993-03-05 MX MX9301903A patent/MX9301903A/es unknown
- 1993-03-05 JP JP51744493A patent/JP3195352B2/ja not_active Expired - Fee Related
- 1993-03-05 AU AU37382/93A patent/AU3738293A/en not_active Abandoned
- 1993-03-05 EP EP93906296A patent/EP0634930A4/en not_active Withdrawn
- 1993-03-05 WO PCT/US1993/001988 patent/WO1993019747A1/en not_active Application Discontinuation
- 1993-03-05 US US08/313,096 patent/US5602173A/en not_active Expired - Lifetime
- 1993-03-30 IL IL10522393A patent/IL105223A0/xx unknown
- 1993-04-01 MA MA23149A patent/MA22923A1/fr unknown
- 1993-04-02 SI SI9300170A patent/SI9300170A/sl unknown
- 1993-04-02 CN CN93105721A patent/CN1094711A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1094711A (zh) | 1994-11-09 |
US5602173A (en) | 1997-02-11 |
WO1993019747A1 (en) | 1993-10-14 |
MA22923A1 (fr) | 1994-04-01 |
MX9301903A (es) | 1994-08-31 |
JP3195352B2 (ja) | 2001-08-06 |
AU3738293A (en) | 1993-11-08 |
EP0634930A1 (en) | 1995-01-25 |
JPH07508261A (ja) | 1995-09-14 |
SI9300170A (sl) | 1993-12-31 |
EP0634930A4 (en) | 1995-02-22 |
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