IL105020A - 2-(2-carbamoyl- 4-pyrrolidinylthio) carbapenem derivatives, processes for their preparation and pharmaceutical compositions containing them - Google Patents

2-(2-carbamoyl- 4-pyrrolidinylthio) carbapenem derivatives, processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL105020A
IL105020A IL105020A IL10502093A IL105020A IL 105020 A IL105020 A IL 105020A IL 105020 A IL105020 A IL 105020A IL 10502093 A IL10502093 A IL 10502093A IL 105020 A IL105020 A IL 105020A
Authority
IL
Israel
Prior art keywords
group
carbon atoms
hydrogen atom
pyrrolidinylthio
carbamoyl
Prior art date
Application number
IL105020A
Other languages
English (en)
Other versions
IL105020A0 (en
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of IL105020A0 publication Critical patent/IL105020A0/xx
Publication of IL105020A publication Critical patent/IL105020A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
IL105020A 1992-03-11 1993-03-11 2-(2-carbamoyl- 4-pyrrolidinylthio) carbapenem derivatives, processes for their preparation and pharmaceutical compositions containing them IL105020A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5216392 1992-03-11
JP24495392 1992-09-14
JP24657892 1992-09-16

Publications (2)

Publication Number Publication Date
IL105020A0 IL105020A0 (en) 1993-07-08
IL105020A true IL105020A (en) 1997-04-15

Family

ID=27294566

Family Applications (1)

Application Number Title Priority Date Filing Date
IL105020A IL105020A (en) 1992-03-11 1993-03-11 2-(2-carbamoyl- 4-pyrrolidinylthio) carbapenem derivatives, processes for their preparation and pharmaceutical compositions containing them

Country Status (18)

Country Link
EP (1) EP0560613B1 (cs)
KR (1) KR100258225B1 (cs)
CN (1) CN1037180C (cs)
AT (1) ATE173733T1 (cs)
AU (1) AU664422B2 (cs)
CA (1) CA2091486A1 (cs)
CZ (1) CZ290002B6 (cs)
DE (1) DE69322188T2 (cs)
DK (1) DK0560613T3 (cs)
ES (1) ES2125945T3 (cs)
FI (1) FI103046B1 (cs)
HU (1) HU218676B (cs)
IL (1) IL105020A (cs)
MX (1) MX9301361A (cs)
NO (1) NO303730B1 (cs)
NZ (1) NZ247129A (cs)
RU (1) RU2097383C1 (cs)
TW (1) TW249803B (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ167792A3 (en) * 1991-06-04 1995-12-13 Sankyo Co 1-methylcarbapenem derivatives process of their preparation and use
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
WO1997023483A1 (en) * 1995-12-21 1997-07-03 Sankyo Company, Limited 1-methylcarbapenem derivatives
HUP9902149A3 (en) * 1996-04-26 2002-01-28 Sankyo Company Ltd Chuo Ku 1-methylcarbapenem derivatives with antibacterial activity, use thereof, pharmaceutical compositions containing these compounds
EP0923545A1 (en) 1996-08-17 1999-06-23 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
WO2000034282A1 (fr) * 1998-12-07 2000-06-15 Sankyo Company, Limited Derives de 1-methylcarbapenem
US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
GB9930317D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
AU2002341747B2 (en) * 2001-09-26 2007-10-18 Merck Sharp & Dohme Corp. Process for making carbapenem compounds
WO2005063704A1 (ja) * 2003-12-25 2005-07-14 Ono Pharmaceutical Co., Ltd. アゼチジン環化合物およびその医薬
CN101367814B (zh) * 2007-06-28 2010-12-15 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰哌啶取代的培南衍生物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
DE3780344T2 (de) * 1986-03-27 1993-01-28 Sumitomo Pharma Beta-lactam-verbindungen und deren herstellung.
CA2036163C (en) * 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
FI96863C (fi) * 1990-02-23 1996-09-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten /2-(1-homopiperatsiinikarbonyyli)pyrrolidin-4-yylitio/-6-(1-hydroksietyyli)-1-karbapen-2-eemi-3-karboksylaattisuolojen valmistamiseksi
GB9107363D0 (en) * 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
CZ167792A3 (en) * 1991-06-04 1995-12-13 Sankyo Co 1-methylcarbapenem derivatives process of their preparation and use
JP3367104B2 (ja) * 1992-04-13 2003-01-14 藤沢薬品工業株式会社 抗菌剤としての置換された３−ピロリジニルチオ−カルバペネム化合物

Also Published As

Publication number Publication date
HUT64071A (en) 1993-11-29
KR930019674A (ko) 1993-10-18
FI931079A0 (fi) 1993-03-10
HU9300677D0 (en) 1993-05-28
FI103046B (fi) 1999-04-15
NO930884D0 (no) 1993-03-11
ATE173733T1 (de) 1998-12-15
MX9301361A (es) 1994-01-31
EP0560613B1 (en) 1998-11-25
HK1011976A1 (en) 1999-07-23
NO303730B1 (no) 1998-08-24
FI931079L (fi) 1993-09-12
HU218676B (hu) 2000-10-28
FI103046B1 (fi) 1999-04-15
CZ290002B6 (cs) 2002-05-15
NO930884L (no) 1993-09-13
CN1037180C (zh) 1998-01-28
DE69322188D1 (de) 1999-01-07
NZ247129A (en) 1994-09-27
EP0560613A1 (en) 1993-09-15
KR100258225B1 (ko) 2000-08-01
DE69322188T2 (de) 1999-07-29
CZ39393A3 (en) 1993-12-15
TW249803B (cs) 1995-06-21
CA2091486A1 (en) 1993-09-12
RU2097383C1 (ru) 1997-11-27
IL105020A0 (en) 1993-07-08
ES2125945T3 (es) 1999-03-16
AU664422B2 (en) 1995-11-16
AU3515193A (en) 1993-09-16
DK0560613T3 (da) 1999-08-09
CN1079472A (zh) 1993-12-15

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Legal Events

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KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees