IL103204A - 2 -) Benzisoxazole - 3 - il (- 7] 2 -) 01 - Hydroxy (- 7, 9-Dioxo - 8 - Azaspiro [4, 5 [Decane - 8 - il - ethyl [Prehydro-H-1-pyrido] A-1,2 [pyrazines - Google Patents

2 -) Benzisoxazole - 3 - il (- 7] 2 -) 01 - Hydroxy (- 7, 9-Dioxo - 8 - Azaspiro [4, 5 [Decane - 8 - il - ethyl [Prehydro-H-1-pyrido] A-1,2 [pyrazines

Info

Publication number
IL103204A
IL103204A IL10320492A IL10320492A IL103204A IL 103204 A IL103204 A IL 103204A IL 10320492 A IL10320492 A IL 10320492A IL 10320492 A IL10320492 A IL 10320492A IL 103204 A IL103204 A IL 103204A
Authority
IL
Israel
Prior art keywords
compound
methylene chloride
preparation
neuroleptic
liters
Prior art date
Application number
IL10320492A
Other languages
English (en)
Hebrew (he)
Other versions
IL103204A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL103204A0 publication Critical patent/IL103204A0/xx
Publication of IL103204A publication Critical patent/IL103204A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
IL10320492A 1991-09-25 1992-09-17 2 -) Benzisoxazole - 3 - il (- 7] 2 -) 01 - Hydroxy (- 7, 9-Dioxo - 8 - Azaspiro [4, 5 [Decane - 8 - il - ethyl [Prehydro-H-1-pyrido] A-1,2 [pyrazines IL103204A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76533291A 1991-09-25 1991-09-25

Publications (2)

Publication Number Publication Date
IL103204A0 IL103204A0 (en) 1993-02-21
IL103204A true IL103204A (en) 1996-05-14

Family

ID=25073279

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10320492A IL103204A (en) 1991-09-25 1992-09-17 2 -) Benzisoxazole - 3 - il (- 7] 2 -) 01 - Hydroxy (- 7, 9-Dioxo - 8 - Azaspiro [4, 5 [Decane - 8 - il - ethyl [Prehydro-H-1-pyrido] A-1,2 [pyrazines

Country Status (25)

Country Link
US (1) US5565453A (tr)
EP (1) EP0607163B1 (tr)
JP (1) JPH08827B2 (tr)
CN (1) CN1071167A (tr)
AT (1) ATE146178T1 (tr)
AU (1) AU655071B2 (tr)
BR (1) BR9206541A (tr)
CA (1) CA2118936A1 (tr)
CZ (1) CZ281775B6 (tr)
DE (1) DE69215886T2 (tr)
DK (1) DK0607163T3 (tr)
ES (1) ES2096099T3 (tr)
FI (1) FI941377A0 (tr)
GR (1) GR3022483T3 (tr)
HU (1) HUT71488A (tr)
IL (1) IL103204A (tr)
MX (1) MX9205385A (tr)
MY (1) MY108303A (tr)
NO (1) NO941084L (tr)
NZ (1) NZ244473A (tr)
PL (1) PL170889B1 (tr)
PT (1) PT100891A (tr)
TW (1) TW215090B (tr)
WO (1) WO1993006101A1 (tr)
ZA (1) ZA927306B (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT77354A (hu) * 1994-09-30 1998-03-30 Pfizer Inc. 2,7-Szubsztituált oktahidro-1H-pirido[1,2-a]pirazin-származékok, ezeket tartalmazó gyógyszerkészítmények és intermedierek
US5731307A (en) * 1994-09-30 1998-03-24 Pfizer, Inc. Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
PA8469101A1 (es) * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1
MXPA05009660A (es) * 2003-03-12 2005-10-20 Pfizer Prod Inc Derivados azabiciclicos de piridiloximetilo y bencisoxazol.
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
AU2013366668B2 (en) * 2012-12-20 2017-07-20 Janssen Pharmaceutica Nv Novel tricyclic 3,4-dihydro-2H-pyrido[1,2-alpha]pyrazine -1,6-dione derivatives as gamma secretase modulators
KR102171710B1 (ko) 2013-01-17 2020-10-30 얀센 파마슈티카 엔.브이. 감마 세크레타제 조절 인자로서의 신규 치환 피리도-피페라지논 유도체
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
NZ230045A (en) * 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione

Also Published As

Publication number Publication date
PT100891A (pt) 1993-10-29
NZ244473A (en) 1995-04-27
JPH08827B2 (ja) 1996-01-10
ATE146178T1 (de) 1996-12-15
NO941084D0 (no) 1994-03-24
ES2096099T3 (es) 1997-03-01
US5565453A (en) 1996-10-15
AU2460992A (en) 1993-04-27
FI941377A (fi) 1994-03-24
HUT71488A (en) 1995-11-28
JPH06506701A (ja) 1994-07-28
DE69215886D1 (de) 1997-01-23
CA2118936A1 (en) 1993-04-01
MY108303A (en) 1996-09-30
WO1993006101A1 (en) 1993-04-01
TW215090B (tr) 1993-10-21
PL170889B1 (pl) 1997-02-28
EP0607163A1 (en) 1994-07-27
BR9206541A (pt) 1995-04-25
NO941084L (no) 1994-03-24
CZ395792A3 (en) 1994-05-18
GR3022483T3 (en) 1997-05-31
DK0607163T3 (da) 1997-03-17
DE69215886T2 (de) 1997-04-03
EP0607163B1 (en) 1996-12-11
ZA927306B (en) 1994-03-24
AU655071B2 (en) 1994-12-01
CZ281775B6 (cs) 1997-01-15
CN1071167A (zh) 1993-04-21
IL103204A0 (en) 1993-02-21
HU9400851D0 (en) 1994-06-28
FI941377A0 (fi) 1994-03-24
MX9205385A (es) 1993-03-01

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Legal Events

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FF Patent granted
KB Patent renewed
RH Patent void