DE69215886T2 - NEUROLEPTISCH 2-SUBSTITUIERTE PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINE - Google Patents

NEUROLEPTISCH 2-SUBSTITUIERTE PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINE

Info

Publication number
DE69215886T2
DE69215886T2 DE69215886T DE69215886T DE69215886T2 DE 69215886 T2 DE69215886 T2 DE 69215886T2 DE 69215886 T DE69215886 T DE 69215886T DE 69215886 T DE69215886 T DE 69215886T DE 69215886 T2 DE69215886 T2 DE 69215886T2
Authority
DE
Germany
Prior art keywords
pct
neuroleptic
pyrido
pyrazine
substituted perhydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69215886T
Other languages
English (en)
Other versions
DE69215886D1 (de
Inventor
Gene BRIGHT
Kishor DESAI
Thomas Seeger
Teresa Smolarek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE69215886D1 publication Critical patent/DE69215886D1/de
Application granted granted Critical
Publication of DE69215886T2 publication Critical patent/DE69215886T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
DE69215886T 1991-09-25 1992-08-14 NEUROLEPTISCH 2-SUBSTITUIERTE PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINE Expired - Fee Related DE69215886T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76533291A 1991-09-25 1991-09-25
PCT/US1992/006625 WO1993006101A1 (en) 1991-09-25 1992-08-14 NEUROLEPTIC 2-SUBSTITUTED PERHYDRO-1-H-PYRIDO[1,2a]PYRAZINES

Publications (2)

Publication Number Publication Date
DE69215886D1 DE69215886D1 (de) 1997-01-23
DE69215886T2 true DE69215886T2 (de) 1997-04-03

Family

ID=25073279

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69215886T Expired - Fee Related DE69215886T2 (de) 1991-09-25 1992-08-14 NEUROLEPTISCH 2-SUBSTITUIERTE PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINE

Country Status (25)

Country Link
US (1) US5565453A (de)
EP (1) EP0607163B1 (de)
JP (1) JPH08827B2 (de)
CN (1) CN1071167A (de)
AT (1) ATE146178T1 (de)
AU (1) AU655071B2 (de)
BR (1) BR9206541A (de)
CA (1) CA2118936A1 (de)
CZ (1) CZ281775B6 (de)
DE (1) DE69215886T2 (de)
DK (1) DK0607163T3 (de)
ES (1) ES2096099T3 (de)
FI (1) FI941377A0 (de)
GR (1) GR3022483T3 (de)
HU (1) HUT71488A (de)
IL (1) IL103204A (de)
MX (1) MX9205385A (de)
MY (1) MY108303A (de)
NO (1) NO941084L (de)
NZ (1) NZ244473A (de)
PL (1) PL170889B1 (de)
PT (1) PT100891A (de)
TW (1) TW215090B (de)
WO (1) WO1993006101A1 (de)
ZA (1) ZA927306B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9520096A (sl) * 1994-09-30 1998-04-30 Pfizer Inc. Derivati 2,7-substituiranega oktahidro-1H-pirido /1,2-a/ pirazina
WO1996010570A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
PA8469101A1 (es) * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1
EP1608648B1 (de) * 2003-03-12 2012-07-18 Pfizer Products Inc. Azabicyclische pyridyloxymethyl- und benzisoxazol-derivate
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CA2889249C (en) 2012-12-20 2021-02-16 Francois Paul Bischoff Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators
EP2945944B1 (de) 2013-01-17 2016-11-09 Janssen Pharmaceutica, N.V. Neuartige substituierte pyrido-piperazinon-derivate als gamma-sekretase-modulatoren
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
NZ230045A (en) * 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione

Also Published As

Publication number Publication date
HU9400851D0 (en) 1994-06-28
PL170889B1 (pl) 1997-02-28
AU655071B2 (en) 1994-12-01
JPH08827B2 (ja) 1996-01-10
GR3022483T3 (en) 1997-05-31
EP0607163A1 (de) 1994-07-27
CA2118936A1 (en) 1993-04-01
FI941377A (fi) 1994-03-24
ZA927306B (en) 1994-03-24
AU2460992A (en) 1993-04-27
IL103204A0 (en) 1993-02-21
DK0607163T3 (da) 1997-03-17
PT100891A (pt) 1993-10-29
CZ281775B6 (cs) 1997-01-15
MX9205385A (es) 1993-03-01
FI941377A0 (fi) 1994-03-24
EP0607163B1 (de) 1996-12-11
TW215090B (de) 1993-10-21
MY108303A (en) 1996-09-30
HUT71488A (en) 1995-11-28
NO941084D0 (no) 1994-03-24
IL103204A (en) 1996-05-14
WO1993006101A1 (en) 1993-04-01
DE69215886D1 (de) 1997-01-23
ES2096099T3 (es) 1997-03-01
NZ244473A (en) 1995-04-27
BR9206541A (pt) 1995-04-25
CZ395792A3 (en) 1994-05-18
NO941084L (no) 1994-03-24
CN1071167A (zh) 1993-04-21
JPH06506701A (ja) 1994-07-28
US5565453A (en) 1996-10-15
ATE146178T1 (de) 1996-12-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee