IL103109A - Anhydrous process for preparing cefepime dihydrochloride hydrate - Google Patents
Anhydrous process for preparing cefepime dihydrochloride hydrateInfo
- Publication number
- IL103109A IL103109A IL103109A IL10310992A IL103109A IL 103109 A IL103109 A IL 103109A IL 103109 A IL103109 A IL 103109A IL 10310992 A IL10310992 A IL 10310992A IL 103109 A IL103109 A IL 103109A
- Authority
- IL
- Israel
- Prior art keywords
- isomer
- dihydrochloride hydrate
- cefepime dihydrochloride
- anhydrous process
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Revetment (AREA)
- Artificial Fish Reefs (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75710491A | 1991-09-10 | 1991-09-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL103109A0 IL103109A0 (en) | 1993-02-21 |
| IL103109A true IL103109A (en) | 1997-07-13 |
Family
ID=25046366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL103109A IL103109A (en) | 1991-09-10 | 1992-09-08 | Anhydrous process for preparing cefepime dihydrochloride hydrate |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0531981B1 (no) |
| JP (1) | JP3434840B2 (no) |
| KR (1) | KR0178280B1 (no) |
| CN (2) | CN1036587C (no) |
| AT (1) | ATE209209T1 (no) |
| AU (1) | AU655838B2 (no) |
| BG (1) | BG61189B1 (no) |
| CA (1) | CA2077836A1 (no) |
| CZ (2) | CZ282315B6 (no) |
| DE (1) | DE69232216T2 (no) |
| DK (1) | DK0531981T3 (no) |
| EG (1) | EG20184A (no) |
| ES (1) | ES2165351T3 (no) |
| FI (2) | FI109127B (no) |
| HU (1) | HU212782B (no) |
| IL (1) | IL103109A (no) |
| MX (1) | MX9205147A (no) |
| NO (1) | NO301930B1 (no) |
| NZ (1) | NZ244295A (no) |
| OA (1) | OA09764A (no) |
| PH (1) | PH31206A (no) |
| PL (1) | PL174820B1 (no) |
| PT (1) | PT531981E (no) |
| RO (1) | RO109651B1 (no) |
| RU (1) | RU2042681C1 (no) |
| SK (2) | SK280934B6 (no) |
| UY (1) | UY23475A1 (no) |
| YU (1) | YU81692A (no) |
| ZA (1) | ZA926866B (no) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL103110A (en) * | 1991-09-10 | 1997-04-15 | Bristol Myers Squibb Co | Anhydrous process for preparing cefepime dihydrochloride hydrate |
| CA2101571A1 (en) * | 1992-09-08 | 1994-03-09 | Elizabeth A. Garofalo | Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof |
| KR19980019860A (ko) * | 1996-09-04 | 1998-06-25 | 김윤배 | 세팔로스포린 중간체의 신규한 제조방법 |
| EP1618114B1 (en) * | 2003-04-16 | 2010-07-14 | Sandoz AG | Processes for the preparations of cefepime |
| US7847093B2 (en) | 2003-04-16 | 2010-12-07 | Sandoz Ag | Processes for the preparations of cefepime |
| GB0416379D0 (en) * | 2004-07-22 | 2004-08-25 | Sandoz Ag | Organic compounds |
| ITMI20051684A1 (it) * | 2005-09-13 | 2007-03-14 | Harvest Lodge Ltd | Procedimento per la produzione del dicloridrato di amminoacidi |
| RU2469040C1 (ru) * | 2011-12-07 | 2012-12-10 | Общество с ограниченной ответственностью "КОМПАНИЯ "ДЕКО" | Способ получения 7-[2-(2-аминотиазол-4-ил)-2(z)-метоксииминоацетамидо]-3-[(1-метил-1-пирролидино)метил]-цеф-3-ем-4-карбоксилата дигидрохлорида моногидрата (цефепима дигидрохлорида моногидрата) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1213882A (en) * | 1982-03-04 | 1986-11-12 | Jun Okumura | Cephalosporins |
| DE3419015A1 (de) * | 1984-05-22 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von cephalosporinen |
| GB2165245B (en) * | 1984-10-01 | 1988-05-25 | Glaxo Group Ltd | Chemical compounds |
| US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
| US4714760A (en) * | 1985-08-20 | 1987-12-22 | Bristol-Myers Company | Cephalosporin intermediates |
| IL103110A (en) * | 1991-09-10 | 1997-04-15 | Bristol Myers Squibb Co | Anhydrous process for preparing cefepime dihydrochloride hydrate |
-
1992
- 1992-09-04 YU YU81692A patent/YU81692A/sh unknown
- 1992-09-08 IL IL103109A patent/IL103109A/xx not_active IP Right Cessation
- 1992-09-09 NO NO923495A patent/NO301930B1/no not_active IP Right Cessation
- 1992-09-09 RU SU925052816A patent/RU2042681C1/ru active
- 1992-09-09 EP EP92115443A patent/EP0531981B1/en not_active Expired - Lifetime
- 1992-09-09 PH PH44905A patent/PH31206A/en unknown
- 1992-09-09 CN CN92110242A patent/CN1036587C/zh not_active Expired - Lifetime
- 1992-09-09 JP JP28213592A patent/JP3434840B2/ja not_active Expired - Lifetime
- 1992-09-09 DE DE69232216T patent/DE69232216T2/de not_active Expired - Lifetime
- 1992-09-09 CZ CZ96719A patent/CZ282315B6/cs not_active IP Right Cessation
- 1992-09-09 PT PT92115443T patent/PT531981E/pt unknown
- 1992-09-09 ES ES92115443T patent/ES2165351T3/es not_active Expired - Lifetime
- 1992-09-09 ZA ZA926866A patent/ZA926866B/xx unknown
- 1992-09-09 EG EG52692A patent/EG20184A/xx active
- 1992-09-09 CZ CS922780A patent/CZ282160B6/cs not_active IP Right Cessation
- 1992-09-09 DK DK92115443T patent/DK0531981T3/da active
- 1992-09-09 HU HU9202884A patent/HU212782B/hu not_active IP Right Cessation
- 1992-09-09 PL PL92295873A patent/PL174820B1/pl not_active IP Right Cessation
- 1992-09-09 OA OA60269A patent/OA09764A/fr unknown
- 1992-09-09 AU AU22844/92A patent/AU655838B2/en not_active Expired
- 1992-09-09 SK SK336-98A patent/SK280934B6/sk not_active IP Right Cessation
- 1992-09-09 AT AT92115443T patent/ATE209209T1/de active
- 1992-09-09 RO RO92-01175A patent/RO109651B1/ro unknown
- 1992-09-09 FI FI924031A patent/FI109127B/fi not_active IP Right Cessation
- 1992-09-09 SK SK2780-92A patent/SK280933B6/sk not_active IP Right Cessation
- 1992-09-09 MX MX9205147A patent/MX9205147A/es unknown
- 1992-09-09 UY UY23475A patent/UY23475A1/es not_active IP Right Cessation
- 1992-09-09 KR KR1019920016595A patent/KR0178280B1/ko not_active IP Right Cessation
- 1992-09-09 CA CA002077836A patent/CA2077836A1/en not_active Abandoned
- 1992-09-10 BG BG96859A patent/BG61189B1/bg unknown
- 1992-09-10 NZ NZ244295A patent/NZ244295A/en not_active IP Right Cessation
-
1996
- 1996-12-05 CN CN96121883A patent/CN1059438C/zh not_active Expired - Lifetime
-
2001
- 2001-10-01 FI FI20011921A patent/FI119811B/fi not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL103109A (en) | Anhydrous process for preparing cefepime dihydrochloride hydrate | |
| IL103110A (en) | Anhydrous process for preparing cefepime dihydrochloride hydrate | |
| TH13935EX (th) | การเตรียมสารปฏิชีวนะกลุ่มเซฟาโลสพอริน โดยใช้ syn-ไอโซเมอร์ของไธอะไซลิล อินเทอร์มิเดียท |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |