ES2165351T3 - Procedimiento de preparacion de un antibiotico cefalosporina. - Google Patents

Procedimiento de preparacion de un antibiotico cefalosporina.

Info

Publication number
ES2165351T3
ES2165351T3 ES92115443T ES92115443T ES2165351T3 ES 2165351 T3 ES2165351 T3 ES 2165351T3 ES 92115443 T ES92115443 T ES 92115443T ES 92115443 T ES92115443 T ES 92115443T ES 2165351 T3 ES2165351 T3 ES 2165351T3
Authority
ES
Spain
Prior art keywords
antibiotic
cephalosporine
preparation procedure
acilation
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92115443T
Other languages
English (en)
Inventor
Gary M F Lim
John M Roubie
Elizabeth Ann Garofalo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2165351T3 publication Critical patent/ES2165351T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Revetment (AREA)
  • Artificial Fish Reefs (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN PROCESO DE ACILACION ANHIDRA PARA LA PREPARACION DE UN HIDRATO DE DIHIDROCLORURO DE CEFEPIME ANTIBIOTICO QUE ESTA SUBSTANCIALMENTE LIBRE DEL ANTIISOMERO Y DEL ISOMERO DELTA2 QUE COMPRENDE LA N-ACILACION DE UN DERIVADO SILILATADO DE 7 INIO) DEL HIDROCLORURO DE CLORURO DE ACEITLO DE 2
ES92115443T 1991-09-10 1992-09-09 Procedimiento de preparacion de un antibiotico cefalosporina. Expired - Lifetime ES2165351T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75710491A 1991-09-10 1991-09-10

Publications (1)

Publication Number Publication Date
ES2165351T3 true ES2165351T3 (es) 2002-03-16

Family

ID=25046366

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92115443T Expired - Lifetime ES2165351T3 (es) 1991-09-10 1992-09-09 Procedimiento de preparacion de un antibiotico cefalosporina.

Country Status (29)

Country Link
EP (1) EP0531981B1 (es)
JP (1) JP3434840B2 (es)
KR (1) KR0178280B1 (es)
CN (2) CN1036587C (es)
AT (1) ATE209209T1 (es)
AU (1) AU655838B2 (es)
BG (1) BG61189B1 (es)
CA (1) CA2077836A1 (es)
CZ (2) CZ282315B6 (es)
DE (1) DE69232216T2 (es)
DK (1) DK0531981T3 (es)
EG (1) EG20184A (es)
ES (1) ES2165351T3 (es)
FI (2) FI109127B (es)
HU (1) HU212782B (es)
IL (1) IL103109A (es)
MX (1) MX9205147A (es)
NO (1) NO301930B1 (es)
NZ (1) NZ244295A (es)
OA (1) OA09764A (es)
PH (1) PH31206A (es)
PL (1) PL174820B1 (es)
PT (1) PT531981E (es)
RO (1) RO109651B1 (es)
RU (1) RU2042681C1 (es)
SK (2) SK280934B6 (es)
UY (1) UY23475A1 (es)
YU (1) YU81692A (es)
ZA (1) ZA926866B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103110A (en) * 1991-09-10 1997-04-15 Bristol Myers Squibb Co Anhydrous process for preparing cefepime dihydrochloride hydrate
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
KR19980019860A (ko) * 1996-09-04 1998-06-25 김윤배 세팔로스포린 중간체의 신규한 제조방법
EP1618114B1 (en) * 2003-04-16 2010-07-14 Sandoz AG Processes for the preparations of cefepime
US7847093B2 (en) 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
GB0416379D0 (en) * 2004-07-22 2004-08-25 Sandoz Ag Organic compounds
ITMI20051684A1 (it) * 2005-09-13 2007-03-14 Harvest Lodge Ltd Procedimento per la produzione del dicloridrato di amminoacidi
RU2469040C1 (ru) * 2011-12-07 2012-12-10 Общество с ограниченной ответственностью "КОМПАНИЯ "ДЕКО" Способ получения 7-[2-(2-аминотиазол-4-ил)-2(z)-метоксииминоацетамидо]-3-[(1-метил-1-пирролидино)метил]-цеф-3-ем-4-карбоксилата дигидрохлорида моногидрата (цефепима дигидрохлорида моногидрата)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
IL103110A (en) * 1991-09-10 1997-04-15 Bristol Myers Squibb Co Anhydrous process for preparing cefepime dihydrochloride hydrate

Also Published As

Publication number Publication date
HU9202884D0 (en) 1992-11-30
SK278092A3 (en) 2000-09-12
CZ71996A3 (en) 1997-06-11
IL103109A (en) 1997-07-13
UY23475A1 (es) 1992-10-08
CN1059438C (zh) 2000-12-13
HU212782B (en) 1996-11-28
NO923495D0 (no) 1992-09-09
FI119811B (fi) 2009-03-31
NZ244295A (en) 1995-08-28
NO301930B1 (no) 1997-12-29
HUT62901A (en) 1993-06-28
FI924031A (fi) 1993-03-11
BG61189B1 (bg) 1997-02-28
SK33698A3 (en) 2000-09-12
CN1070398A (zh) 1993-03-31
DE69232216T2 (de) 2002-06-27
RO109651B1 (ro) 1995-04-28
SK280933B6 (sk) 2000-09-12
BG96859A (bg) 1993-12-24
FI924031A0 (fi) 1992-09-09
EP0531981A1 (en) 1993-03-17
ATE209209T1 (de) 2001-12-15
AU655838B2 (en) 1995-01-12
NO923495L (no) 1993-03-11
PT531981E (pt) 2002-05-31
PL174820B1 (pl) 1998-09-30
IL103109A0 (en) 1993-02-21
CN1158333A (zh) 1997-09-03
SK280934B6 (sk) 2000-09-12
CZ282315B6 (cs) 1997-06-11
PH31206A (en) 1998-05-05
KR930006032A (ko) 1993-04-20
CA2077836A1 (en) 1993-03-11
DE69232216D1 (de) 2002-01-03
PL295873A1 (en) 1993-05-04
CZ278092A3 (en) 1993-03-17
FI109127B (fi) 2002-05-31
CZ282160B6 (cs) 1997-05-14
EP0531981B1 (en) 2001-11-21
JPH05194532A (ja) 1993-08-03
KR0178280B1 (ko) 1999-03-20
YU81692A (sh) 1995-03-27
AU2284492A (en) 1993-03-11
RU2042681C1 (ru) 1995-08-27
DK0531981T3 (da) 2002-05-21
ZA926866B (en) 1993-03-09
CN1036587C (zh) 1997-12-03
FI20011921A (fi) 2001-10-01
MX9205147A (es) 1993-03-01
JP3434840B2 (ja) 2003-08-11
OA09764A (fr) 1993-11-30
EG20184A (en) 1997-09-30

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