IL103011A - 3"- and/or 4"-(benz)imidazolyl (benz)oxazolyl and (benz)thiazolyl substituted macrolides having immunosuppressive activity and pharmaceutical compositions containing them - Google Patents

3"- and/or 4"-(benz)imidazolyl (benz)oxazolyl and (benz)thiazolyl substituted macrolides having immunosuppressive activity and pharmaceutical compositions containing them

Info

Publication number
IL103011A
IL103011A IL10301192A IL10301192A IL103011A IL 103011 A IL103011 A IL 103011A IL 10301192 A IL10301192 A IL 10301192A IL 10301192 A IL10301192 A IL 10301192A IL 103011 A IL103011 A IL 103011A
Authority
IL
Israel
Prior art keywords
benz
oxazolyl
imidazolyl
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL10301192A
Other languages
English (en)
Other versions
IL103011A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL103011A0 publication Critical patent/IL103011A0/xx
Publication of IL103011A publication Critical patent/IL103011A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
IL10301192A 1991-09-09 1992-09-01 3"- and/or 4"-(benz)imidazolyl (benz)oxazolyl and (benz)thiazolyl substituted macrolides having immunosuppressive activity and pharmaceutical compositions containing them IL103011A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75663391A 1991-09-09 1991-09-09
US07/921,181 US5247076A (en) 1991-09-09 1992-08-04 Imidazolidyl macrolides having immunosuppressive activity
CA002116674A CA2116674C (en) 1991-09-09 1992-09-02 Imidazolidyl macrolides

Publications (2)

Publication Number Publication Date
IL103011A0 IL103011A0 (en) 1993-02-21
IL103011A true IL103011A (en) 1997-02-18

Family

ID=27169717

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10301192A IL103011A (en) 1991-09-09 1992-09-01 3"- and/or 4"-(benz)imidazolyl (benz)oxazolyl and (benz)thiazolyl substituted macrolides having immunosuppressive activity and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (2) US5247076A (de)
EP (1) EP0536896B1 (de)
JP (1) JP3098032B2 (de)
AT (1) ATE161266T1 (de)
AU (1) AU669672B2 (de)
BG (1) BG98640A (de)
CA (1) CA2116674C (de)
CZ (1) CZ47394A3 (de)
DE (1) DE69223583T2 (de)
DK (1) DK0536896T3 (de)
ES (1) ES2111615T3 (de)
FI (1) FI941084A7 (de)
GR (1) GR3025993T3 (de)
HU (1) HUT67267A (de)
IL (1) IL103011A (de)
NO (1) NO940804L (de)
NZ (1) NZ244154A (de)
PL (2) PL172789B1 (de)
RO (1) RO112620B1 (de)
RU (1) RU2108338C1 (de)
SK (1) SK28694A3 (de)
WO (1) WO1993005059A1 (de)
ZA (1) ZA926813B (de)

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US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5310903A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. Imidazolidyl rapamycin derivatives
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US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
WO1995020590A1 (en) * 1994-01-27 1995-08-03 The Trustees Of Columbia University In The City Of New York Enantioselective receptors for amino acid derivatives, and other compounds
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US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5491159A (en) * 1994-08-30 1996-02-13 American Home Products Corporation 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-oxazoles as anti-atherosclerotic agents
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
CN100335063C (zh) 1994-10-26 2007-09-05 诺瓦蒂斯有限公司 药物组合物
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
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US5777105A (en) * 1995-08-24 1998-07-07 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
CA2229718A1 (en) * 1995-08-24 1997-03-06 David J. Mathre Process for the preparation of imidazolyl macrolide immunosuppressants
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
US5877184A (en) * 1996-08-06 1999-03-02 Merck & Co., Inc. Macrolides having immunosuppressive activity
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ME00189B (me) 1998-03-26 2011-02-10 Astellas Pharma Inc Preparati sa neprekidnim oslobađanjem
CA2326222C (en) * 1998-04-27 2008-09-23 Fujisawa Pharmaceutical Co., Ltd. Medicinal compositions
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
ATE264863T1 (de) * 1999-08-24 2004-05-15 Ariad Gene Therapeutics Inc 28-epirapaloge
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
RU2189206C2 (ru) * 2000-02-04 2002-09-20 Ченцова Екатерина Валериановна Способ лечения дефектов роговицы
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
TWI324925B (en) * 2001-08-23 2010-05-21 Novartis Ag Ophthalmic composition
GB0125443D0 (en) * 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US7179827B2 (en) * 2004-03-31 2007-02-20 Lexicon Genetics Incorporated Thiazoles and methods of their use
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
TW200637869A (en) * 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
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EP2063905B1 (de) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
US8921642B2 (en) * 2008-01-11 2014-12-30 Massachusetts Eye And Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CA2815085C (en) 2010-10-22 2022-06-21 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
EP2839038B1 (de) 2012-04-20 2019-01-16 T2 Biosystems, Inc. Zusammensetzungen und verfahren für den nachweis einer candida-spezies
EP3008192B1 (de) 2013-06-11 2019-07-17 Takara Bio USA, Inc. Proteinangereicherte mikrovesikel und verfahren zur herstellung und verwendung davon
US10143682B2 (en) 2014-10-28 2018-12-04 Koushi Yamaguchi Medicine for improving state of pregnancy, and use thereof
EP3400945A4 (de) 2016-01-08 2019-09-11 Nippon Kayaku Kabushiki Kaisha Polymerderivat von macrolid-immunosuppressiva
JP7523776B2 (ja) 2016-01-21 2024-07-29 ティー２ バイオシステムズ，インコーポレーテッド 細菌を迅速に検出するｎｍｒ法及びシステム
US20210228551A1 (en) 2018-08-10 2021-07-29 Koushi Yamaguchi Therapeutic agent for humoral immunity-related diseases in maternofetal relationship
CN120053439A (zh) 2018-12-18 2025-05-30 山口晃史 用于改善不孕不育症或妊娠状态的药物

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DK175235B1 (da) * 1987-11-09 2004-07-19 Novartis Ag Ny anvendelse af azatricycloderivater og farmaceutiske præparater med indhold deraf
KR920700212A (ko) * 1989-06-14 1992-02-19 쟝 크라머·한스 루돌프 하우스 헤테로원자-함유 트리사이클릭 화합물
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US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
US5064835A (en) * 1990-03-01 1991-11-12 Merck & Co., Inc. Hydroxymacrolide derivatives having immunosuppressive activity
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US5262533A (en) * 1991-05-13 1993-11-16 Merck & Co., Inc. Amino O-aryl macrolides having immunosuppressive activity
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Also Published As

Publication number Publication date
FI941084A0 (fi) 1994-03-08
AU2660992A (en) 1993-04-05
NO940804L (no) 1994-05-06
DE69223583D1 (de) 1998-01-29
CA2116674A1 (en) 1993-03-18
BG98640A (bg) 1995-05-31
WO1993005059A1 (en) 1993-03-18
AU669672B2 (en) 1996-06-20
IL103011A0 (en) 1993-02-21
US5344925A (en) 1994-09-06
HUT67267A (en) 1995-03-28
JPH06510303A (ja) 1994-11-17
PL172789B1 (pl) 1997-11-28
ZA926813B (en) 1994-03-07
FI941084L (fi) 1994-03-08
RO112620B1 (ro) 1997-11-28
NO940804D0 (no) 1994-03-08
CA2116674C (en) 2002-09-17
CZ47394A3 (en) 1994-10-19
GR3025993T3 (en) 1998-04-30
NZ244154A (en) 1995-05-26
JP3098032B2 (ja) 2000-10-10
EP0536896A1 (de) 1993-04-14
PL172637B1 (pl) 1997-10-31
US5247076A (en) 1993-09-21
ES2111615T3 (es) 1998-03-16
HU9400687D0 (en) 1994-06-28
ATE161266T1 (de) 1998-01-15
DK0536896T3 (da) 1998-01-19
SK28694A3 (en) 1994-08-10
EP0536896B1 (de) 1997-12-17
DE69223583T2 (de) 1998-07-02
RU2108338C1 (ru) 1998-04-10
FI941084A7 (fi) 1994-03-08

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