IL102652A - History of indole, their preparation and the pharmaceutical preparations containing them - Google Patents

History of indole, their preparation and the pharmaceutical preparations containing them

Info

Publication number
IL102652A
IL102652A IL10265292A IL10265292A IL102652A IL 102652 A IL102652 A IL 102652A IL 10265292 A IL10265292 A IL 10265292A IL 10265292 A IL10265292 A IL 10265292A IL 102652 A IL102652 A IL 102652A
Authority
IL
Israel
Prior art keywords
denotes
group
hydroxyl
substituted
lower alkyl
Prior art date
Application number
IL10265292A
Other languages
English (en)
Hebrew (he)
Other versions
IL102652A0 (en
Original Assignee
Kali Chemie Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma Gmbh filed Critical Kali Chemie Pharma Gmbh
Publication of IL102652A0 publication Critical patent/IL102652A0/xx
Publication of IL102652A publication Critical patent/IL102652A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
IL10265292A 1991-08-23 1992-07-27 History of indole, their preparation and the pharmaceutical preparations containing them IL102652A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4128015A DE4128015A1 (de) 1991-08-23 1991-08-23 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
IL102652A0 IL102652A0 (en) 1993-01-14
IL102652A true IL102652A (en) 1996-07-23

Family

ID=6438970

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10265292A IL102652A (en) 1991-08-23 1992-07-27 History of indole, their preparation and the pharmaceutical preparations containing them

Country Status (21)

Country Link
US (1) US5324725A (fi)
EP (1) EP0529452B1 (fi)
JP (1) JP3162495B2 (fi)
KR (1) KR930004308A (fi)
CN (1) CN1069732A (fi)
AT (1) ATE173260T1 (fi)
AU (1) AU657557B2 (fi)
CA (1) CA2076553A1 (fi)
CZ (1) CZ281568B6 (fi)
DE (2) DE4128015A1 (fi)
ES (1) ES2126581T3 (fi)
FI (1) FI923774A (fi)
HU (1) HUT64762A (fi)
IL (1) IL102652A (fi)
MX (1) MX9204858A (fi)
NO (1) NO300543B1 (fi)
NZ (1) NZ243774A (fi)
PH (1) PH31172A (fi)
RU (1) RU2083580C1 (fi)
TW (1) TW222277B (fi)
ZA (1) ZA926275B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4233715A1 (de) * 1992-10-07 1994-04-14 Bayer Ag Substituierte Carbamoylpyrazoline
DE4304806A1 (de) * 1993-02-17 1994-08-18 Kali Chemie Pharma Gmbh 5-Phenyl-pyrrolo-1,4-benzoxazin- und -thiazin-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2710914B1 (fr) * 1993-10-04 1995-11-24 Synthelabo Dérivés de 2-[2-(tétrazol-5-yl)phényl]-1,2-dihydroquinoléine, leur préparation et leur utilisation comme intermédiaires de synthèse.
EP1118612A1 (en) * 2000-01-21 2001-07-25 Universita Degli Studi di Firenze Piperazine derivatives possesing nootropic activity
JP4705587B2 (ja) * 2003-12-17 2011-06-22 ナームローゼ・フエンノートチヤツプ・オルガノン カンナビノイドcb1受容体アゴニストとしての三環式1−[(3−インドール−3−イル)カルボニル]ピペラジン誘導体
SG181927A1 (en) * 2009-12-23 2012-07-30 Arqule Inc Purified pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same
WO2011082266A2 (en) 2009-12-30 2011-07-07 Arqule, Inc. Substituted heterocyclic compounds
US9216998B2 (en) 2012-02-15 2015-12-22 Janssen Pharmaceutica Nv Tricyclic indole derivatives useful endothelial lipase inhibitors
WO2014047427A2 (en) 2012-09-21 2014-03-27 Vanderbilt University Substituted benzofuran, benzothiophene and indole mcl-1 inhibitors
CZ305460B6 (cs) * 2013-05-06 2015-10-07 Contipro Biotech S.R.O. Způsob přípravy esteru 2-oxoglutarátu, přípravek obsahující ester 2-oxoglutarát a jeho použití
WO2015031608A1 (en) 2013-08-28 2015-03-05 Vanderbilt University Substituted indole mcl-1 inhibitors
CA2943815C (en) 2014-03-27 2023-04-04 Vanderbilt University Substituted indole mcl-1 inhibitors
US9949965B2 (en) * 2014-10-17 2018-04-24 Vanderbilt University Tricyclic indole Mcl-1 inhibitors and uses thereof
JP7086395B2 (ja) 2016-03-04 2022-06-20 ヴァンダービルト ユニバーシティー 置換インドールMcl-1阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
US4985420A (en) * 1987-12-10 1991-01-15 Duphar International Research B.V. 1,7-annelated indolecarboxylic acid esters and -amides
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
PH26955A (en) * 1989-03-08 1992-12-03 Kali Chemie Pharma Gmbh Novel 1,7-fused 1H-indole-2-carboxylic acid N-(1,4-benzodiazepin-3-YL) amides

Also Published As

Publication number Publication date
HU9202659D0 (en) 1992-10-28
US5324725A (en) 1994-06-28
NO300543B1 (no) 1997-06-16
EP0529452A2 (de) 1993-03-03
ZA926275B (en) 1993-03-02
AU2124992A (en) 1993-02-25
DE4128015A1 (de) 1993-02-25
PH31172A (en) 1998-03-20
IL102652A0 (en) 1993-01-14
TW222277B (fi) 1994-04-11
NO923282L (no) 1993-02-24
KR930004308A (ko) 1993-03-22
JP3162495B2 (ja) 2001-04-25
NZ243774A (en) 1994-07-26
CZ258592A3 (en) 1993-03-17
NO923282D0 (no) 1992-08-21
FI923774A0 (fi) 1992-08-21
CN1069732A (zh) 1993-03-10
HUT64762A (en) 1994-02-28
FI923774A (fi) 1993-02-24
ES2126581T3 (es) 1999-04-01
AU657557B2 (en) 1995-03-16
EP0529452A3 (de) 1993-04-21
CZ281568B6 (cs) 1996-11-13
MX9204858A (es) 1993-05-01
JPH05208956A (ja) 1993-08-20
CA2076553A1 (en) 1993-02-24
RU2083580C1 (ru) 1997-07-10
EP0529452B1 (de) 1998-11-11
DE59209553D1 (de) 1998-12-17
ATE173260T1 (de) 1998-11-15

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Legal Events

Date Code Title Description
HK Corrigendum

Free format text: JOURNAL NO. 4/96 P. 1102, PATENT APPLICATION NO. 102652 CORRECT THE CLASSIFICATION, ITEM (51), TO C07D471/06, 487/06, 498/06, 513/06; A61K 31/395

FF Patent granted
KB Patent renewed
HC Change of name of proprietor(s)
RH Patent void