IL101743A - History of 2-Mercaptomethyl-Tetrahydro-Naphthalene 2-Carboxamide and Encaphalin Inhibitors - Google Patents

History of 2-Mercaptomethyl-Tetrahydro-Naphthalene 2-Carboxamide and Encaphalin Inhibitors

Info

Publication number
IL101743A
IL101743A IL10174392A IL10174392A IL101743A IL 101743 A IL101743 A IL 101743A IL 10174392 A IL10174392 A IL 10174392A IL 10174392 A IL10174392 A IL 10174392A IL 101743 A IL101743 A IL 101743A
Authority
IL
Israel
Prior art keywords
compound
carbonyl
naphthalenyl
tetrahydro
methyl
Prior art date
Application number
IL10174392A
Other languages
English (en)
Hebrew (he)
Other versions
IL101743A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL101743A0 publication Critical patent/IL101743A0/xx
Publication of IL101743A publication Critical patent/IL101743A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL10174392A 1991-05-03 1992-04-30 History of 2-Mercaptomethyl-Tetrahydro-Naphthalene 2-Carboxamide and Encaphalin Inhibitors IL101743A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69563591A 1991-05-03 1991-05-03
US07/860,572 US5252601A (en) 1991-05-03 1992-04-03 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors

Publications (2)

Publication Number Publication Date
IL101743A0 IL101743A0 (en) 1992-12-30
IL101743A true IL101743A (en) 1996-05-14

Family

ID=27105626

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10174392A IL101743A (en) 1991-05-03 1992-04-30 History of 2-Mercaptomethyl-Tetrahydro-Naphthalene 2-Carboxamide and Encaphalin Inhibitors

Country Status (17)

Country Link
US (1) US5252601A (fr)
EP (1) EP0516980B1 (fr)
JP (1) JP3291631B2 (fr)
KR (1) KR100237949B1 (fr)
AT (1) ATE136884T1 (fr)
AU (1) AU649807B2 (fr)
CA (1) CA2067408C (fr)
DE (1) DE69209892T2 (fr)
DK (1) DK0516980T3 (fr)
ES (1) ES2089281T3 (fr)
FI (1) FI111252B (fr)
GR (1) GR3019685T3 (fr)
HU (1) HU211730B (fr)
IE (1) IE72082B1 (fr)
IL (1) IL101743A (fr)
NO (1) NO178334C (fr)
NZ (1) NZ242521A (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
JPH09508906A (ja) * 1994-02-14 1997-09-09 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類
EP0746566A1 (fr) * 1994-02-14 1996-12-11 Merrell Pharmaceuticals Inc. Nouveaux derives bisulfure d'idane-2-mercaptoacetylamides substitues en position 2, utiles comme inhibiteurs de l'encephalinase et de l'enzyme de conversion de l'angiotensine (ace)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
EP0136883B1 (fr) * 1983-10-03 1987-11-25 E.R. Squibb & Sons, Inc. Inhibiteurs d'enképhalinase
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
JPH02231464A (ja) * 1988-02-26 1990-09-13 Tanabe Seiyaku Co Ltd インダンオキシ酢酸誘導体
EP0361365A1 (fr) * 1988-09-30 1990-04-04 E.R. SQUIBB & SONS, INC. Composés d'acides aminobenzoiques et aminocyclohexane carboxyliques, compositions, et méthode d'application
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
WO1991009840A1 (fr) * 1989-12-22 1991-07-11 Schering Corporation Inhibiteurs aminoacides mercaptocycloacyliques d'endopeptidase

Also Published As

Publication number Publication date
DE69209892T2 (de) 1996-11-14
IE921408A1 (en) 1992-11-04
GR3019685T3 (en) 1996-07-31
IE72082B1 (en) 1997-03-12
FI921948A (fi) 1992-11-04
ATE136884T1 (de) 1996-05-15
FI921948A0 (fi) 1992-04-30
HU9201474D0 (en) 1992-07-28
IL101743A0 (en) 1992-12-30
EP0516980A1 (fr) 1992-12-09
NO178334B (no) 1995-11-27
DK0516980T3 (da) 1996-05-13
DE69209892D1 (de) 1996-05-23
EP0516980B1 (fr) 1996-04-17
HUT65256A (en) 1994-05-02
AU649807B2 (en) 1994-06-02
ES2089281T3 (es) 1996-10-01
NZ242521A (en) 1994-04-27
CA2067408C (fr) 2003-07-15
NO921706D0 (no) 1992-04-30
AU1516892A (en) 1992-11-05
HU211730B (en) 1995-12-28
NO178334C (no) 1996-03-06
FI111252B (fi) 2003-06-30
NO921706L (no) 1992-11-04
JPH05208952A (ja) 1993-08-20
US5252601A (en) 1993-10-12
JP3291631B2 (ja) 2002-06-10
KR100237949B1 (ko) 2000-01-15
KR920021504A (ko) 1992-12-18
CA2067408A1 (fr) 1992-11-04

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH Patent void
NE Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967)
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees