NO921706D0 - Nye 2-merkaptomethylen-tetrahydronafthalen- og indan-2-carboxamidderivater som enkefalinaseinhibitorer - Google Patents

Nye 2-merkaptomethylen-tetrahydronafthalen- og indan-2-carboxamidderivater som enkefalinaseinhibitorer

Info

Publication number
NO921706D0
NO921706D0 NO921706A NO921706A NO921706D0 NO 921706 D0 NO921706 D0 NO 921706D0 NO 921706 A NO921706 A NO 921706A NO 921706 A NO921706 A NO 921706A NO 921706 D0 NO921706 D0 NO 921706D0
Authority
NO
Norway
Prior art keywords
inhibitors
encyphalinase
captomethylene
afhalene
tetrahydrone
Prior art date
Application number
NO921706A
Other languages
English (en)
Other versions
NO178334B (no
NO178334C (no
NO921706L (no
Inventor
Gary Alan Flynn
Douglas Wade Beight
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO921706D0 publication Critical patent/NO921706D0/no
Publication of NO921706L publication Critical patent/NO921706L/no
Publication of NO178334B publication Critical patent/NO178334B/no
Publication of NO178334C publication Critical patent/NO178334C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/20Esters of monothiocarboxylic acids
    • C07C327/32Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO921706A 1991-05-03 1992-04-30 Nye 2-merkaptomethylen-tetrahydronafthalen- og indan-2-carboxamidderivater som enkefalinaseinhibitorer NO178334C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69563591A 1991-05-03 1991-05-03
US07/860,572 US5252601A (en) 1991-05-03 1992-04-03 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors

Publications (4)

Publication Number Publication Date
NO921706D0 true NO921706D0 (no) 1992-04-30
NO921706L NO921706L (no) 1992-11-04
NO178334B NO178334B (no) 1995-11-27
NO178334C NO178334C (no) 1996-03-06

Family

ID=27105626

Family Applications (1)

Application Number Title Priority Date Filing Date
NO921706A NO178334C (no) 1991-05-03 1992-04-30 Nye 2-merkaptomethylen-tetrahydronafthalen- og indan-2-carboxamidderivater som enkefalinaseinhibitorer

Country Status (17)

Country Link
US (1) US5252601A (no)
EP (1) EP0516980B1 (no)
JP (1) JP3291631B2 (no)
KR (1) KR100237949B1 (no)
AT (1) ATE136884T1 (no)
AU (1) AU649807B2 (no)
CA (1) CA2067408C (no)
DE (1) DE69209892T2 (no)
DK (1) DK0516980T3 (no)
ES (1) ES2089281T3 (no)
FI (1) FI111252B (no)
GR (1) GR3019685T3 (no)
HU (1) HU211730B (no)
IE (1) IE72082B1 (no)
IL (1) IL101743A (no)
NO (1) NO178334C (no)
NZ (1) NZ242521A (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2168355T3 (es) * 1994-02-14 2002-06-16 Merrell Pharma Inc Derivados de bisulfuro de indano-2-mercaptoacetilamida utiles como inhibidores de la encefalinasa.
EP0746566A1 (en) * 1994-02-14 1996-12-11 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
EP0750631B1 (en) * 1994-02-14 2000-04-05 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
DE3467754D1 (de) * 1983-10-03 1988-01-07 Squibb & Sons Inc Enkephalinase inhibitors
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
JPH02231464A (ja) * 1988-02-26 1990-09-13 Tanabe Seiyaku Co Ltd インダンオキシ酢酸誘導体
EP0361365A1 (en) * 1988-09-30 1990-04-04 E.R. SQUIBB & SONS, INC. Aminobenzoic and aminocyclohexane-carboylic acid compounds, compositions, and their method of use
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
AU7168091A (en) * 1989-12-22 1991-07-24 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors

Also Published As

Publication number Publication date
NO178334B (no) 1995-11-27
HU9201474D0 (en) 1992-07-28
NO178334C (no) 1996-03-06
NZ242521A (en) 1994-04-27
HUT65256A (en) 1994-05-02
NO921706L (no) 1992-11-04
DK0516980T3 (da) 1996-05-13
KR100237949B1 (ko) 2000-01-15
JP3291631B2 (ja) 2002-06-10
FI921948A0 (fi) 1992-04-30
EP0516980B1 (en) 1996-04-17
GR3019685T3 (en) 1996-07-31
IL101743A (en) 1996-05-14
ES2089281T3 (es) 1996-10-01
US5252601A (en) 1993-10-12
CA2067408A1 (en) 1992-11-04
IE921408A1 (en) 1992-11-04
FI111252B (fi) 2003-06-30
EP0516980A1 (en) 1992-12-09
DE69209892D1 (de) 1996-05-23
DE69209892T2 (de) 1996-11-14
CA2067408C (en) 2003-07-15
IL101743A0 (en) 1992-12-30
IE72082B1 (en) 1997-03-12
FI921948A (fi) 1992-11-04
AU649807B2 (en) 1994-06-02
JPH05208952A (ja) 1993-08-20
KR920021504A (ko) 1992-12-18
ATE136884T1 (de) 1996-05-15
AU1516892A (en) 1992-11-05
HU211730B (en) 1995-12-28

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