IL100328A - History of dihydro-isoquinoline, their manufacture and pharmaceutical preparations containing them - Google Patents

History of dihydro-isoquinoline, their manufacture and pharmaceutical preparations containing them

Info

Publication number
IL100328A
IL100328A IL10032891A IL10032891A IL100328A IL 100328 A IL100328 A IL 100328A IL 10032891 A IL10032891 A IL 10032891A IL 10032891 A IL10032891 A IL 10032891A IL 100328 A IL100328 A IL 100328A
Authority
IL
Israel
Prior art keywords
compound
ester
formula
acid addition
addition salt
Prior art date
Application number
IL10032891A
Other languages
English (en)
Hebrew (he)
Other versions
IL100328A0 (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL100328A0 publication Critical patent/IL100328A0/xx
Publication of IL100328A publication Critical patent/IL100328A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL10032891A 1990-12-13 1991-12-11 History of dihydro-isoquinoline, their manufacture and pharmaceutical preparations containing them IL100328A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909027055A GB9027055D0 (en) 1990-12-13 1990-12-13 Organic compounds

Publications (2)

Publication Number Publication Date
IL100328A0 IL100328A0 (en) 1992-09-06
IL100328A true IL100328A (en) 1995-12-08

Family

ID=10686945

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10032891A IL100328A (en) 1990-12-13 1991-12-11 History of dihydro-isoquinoline, their manufacture and pharmaceutical preparations containing them

Country Status (25)

Country Link
US (1) US5177085A (fr)
EP (1) EP0490823B1 (fr)
JP (1) JPH0764820B2 (fr)
KR (1) KR920012040A (fr)
AT (1) ATE145201T1 (fr)
AU (1) AU643575B2 (fr)
CA (1) CA2057524A1 (fr)
CZ (1) CZ281669B6 (fr)
DE (1) DE69123124T2 (fr)
DK (1) DK0490823T3 (fr)
ES (1) ES2093694T3 (fr)
FI (1) FI915844A (fr)
GB (1) GB9027055D0 (fr)
GR (1) GR3022034T3 (fr)
HU (1) HUT61729A (fr)
IE (1) IE914325A1 (fr)
IL (1) IL100328A (fr)
MX (1) MX9102502A (fr)
MY (1) MY129941A (fr)
NZ (1) NZ240936A (fr)
PL (1) PL168329B1 (fr)
PT (1) PT99775B (fr)
RU (1) RU2060992C1 (fr)
TW (1) TW201736B (fr)
ZA (1) ZA919858B (fr)

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GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
GB9304920D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
GB9322828D0 (en) * 1993-11-05 1993-12-22 Sandoz Ltd Organic compounds
DE69433594T2 (de) * 1993-12-22 2004-08-05 Celltech R&D Ltd., Slough Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe
GB9326173D0 (en) * 1993-12-22 1994-02-23 Celltech Ltd Chemical compounds and process
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
GB9412571D0 (en) * 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412573D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
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US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
DE69524962T4 (de) * 1994-08-22 2003-08-28 Mitsubishi Pharma Corp., Osaka Benzolderivate und deren medizinische verwendung
US5948820A (en) 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof
ATE247655T1 (de) * 1994-12-13 2003-09-15 Euro Celtique Sa Dreifachsubstituierte thioxanthine
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
US6268373B1 (en) * 1995-06-07 2001-07-31 Euro-Celtique S.A. Trisubstituted thioxanthines
GB9523267D0 (en) * 1995-11-14 1996-01-17 Sandoz Ltd Organic compounds
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
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GB9622363D0 (en) * 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
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GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
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US6410551B1 (en) 1997-07-25 2002-06-25 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrazole derivatives
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IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
IT1302677B1 (it) 1998-10-15 2000-09-29 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
SI1212089T1 (sl) 1999-08-21 2006-08-31 Altana Pharma Ag Sinergisticna kombinacija roflumilasta in salmeterola
GB9924862D0 (en) * 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
EP1270577B1 (fr) * 2000-03-23 2006-12-06 Takeda Pharmaceutical Company Limited Derives de furoisoquinoleine, leur procede de production et leur utilisation
WO2002040450A1 (fr) 2000-11-14 2002-05-23 Altana Pharma Ag Derives de (dihydro)isoquinoline comme inhibiteurs de phosphodiesterase
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ATE348616T1 (de) 2002-08-29 2007-01-15 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
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Family Cites Families (4)

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GB1400425A (en) * 1971-09-22 1975-07-16 Rolland Sa A Substituted 3-hydroxymethyl-isoquinolines and derivatives
HU196758B (en) * 1986-05-21 1989-01-30 Gyogyszerkutato Intezet Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them
CA1330560C (fr) * 1986-05-21 1994-07-05 Maurits E. A. Vandewalle Derives di- et tetrahydroisoquinoline
GB8800397D0 (en) * 1988-01-08 1988-02-10 Sandoz Ltd Improvements in/relating to organic compounds

Also Published As

Publication number Publication date
DE69123124D1 (de) 1996-12-19
HU913760D0 (en) 1992-02-28
FI915844A0 (fi) 1991-12-11
CA2057524A1 (fr) 1992-06-14
DE69123124T2 (de) 1997-05-15
EP0490823A1 (fr) 1992-06-17
JPH04275276A (ja) 1992-09-30
CS375791A3 (en) 1992-06-17
TW201736B (fr) 1993-03-11
MX9102502A (es) 1992-06-01
CZ281669B6 (cs) 1996-12-11
MY129941A (en) 2007-05-31
GR3022034T3 (en) 1997-03-31
DK0490823T3 (fr) 1997-02-17
IL100328A0 (en) 1992-09-06
KR920012040A (ko) 1992-07-25
US5177085A (en) 1993-01-05
FI915844A (fi) 1992-06-14
PT99775B (pt) 1999-05-31
PT99775A (pt) 1992-11-30
RU2060992C1 (ru) 1996-05-27
IE914325A1 (en) 1992-06-17
EP0490823B1 (fr) 1996-11-13
JPH0764820B2 (ja) 1995-07-12
AU8898591A (en) 1992-06-18
AU643575B2 (en) 1993-11-18
PL168329B1 (pl) 1996-02-29
HUT61729A (en) 1993-03-01
GB9027055D0 (en) 1991-02-06
NZ240936A (en) 1993-09-27
ES2093694T3 (es) 1997-01-01
ATE145201T1 (de) 1996-11-15
ZA919858B (en) 1993-06-14
PL292738A1 (en) 1992-12-14

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Legal Events

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