IE63631B1 - Oxadiazolylacetonitriles their preparation and use - Google Patents

Oxadiazolylacetonitriles their preparation and use

Info

Publication number
IE63631B1
IE63631B1 IE930093A IE930093A IE63631B1 IE 63631 B1 IE63631 B1 IE 63631B1 IE 930093 A IE930093 A IE 930093A IE 930093 A IE930093 A IE 930093A IE 63631 B1 IE63631 B1 IE 63631B1
Authority
IE
Ireland
Prior art keywords
oxadiazole
mmol
isocyanomethyl
ethyl
cyclopropyl
Prior art date
Application number
IE930093A
Other languages
English (en)
Inventor
Frank Watjen
Mogens Engelstoft
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK476885A external-priority patent/DK476885D0/da
Priority claimed from DK476985A external-priority patent/DK476985D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IE63631B1 publication Critical patent/IE63631B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Lubricants (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IE930093A 1985-10-17 1986-10-16 Oxadiazolylacetonitriles their preparation and use IE63631B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK476885A DK476885D0 (da) 1985-10-17 1985-10-17 Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DK476985A DK476985D0 (da) 1985-10-17 1985-10-17 Fremgangsmaade til fremstilling af oxadiazolylderivater af imidazobenzodiazepiner og mellemprodukt til brug ved fremgangsmaaden

Publications (1)

Publication Number Publication Date
IE63631B1 true IE63631B1 (en) 1995-05-17

Family

ID=26067609

Family Applications (2)

Application Number Title Priority Date Filing Date
IE930093A IE63631B1 (en) 1985-10-17 1986-10-16 Oxadiazolylacetonitriles their preparation and use
IE273486A IE59830B1 (en) 1985-10-17 1986-10-16 Heterocyclic compounds and their preparation and use

Family Applications After (1)

Application Number Title Priority Date Filing Date
IE273486A IE59830B1 (en) 1985-10-17 1986-10-16 Heterocyclic compounds and their preparation and use

Country Status (17)

Country Link
EP (2) EP0274009B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPH0751577B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR940010035B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (2) ATE44381T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU586043B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1297099C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3686723T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK155007C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2011448B3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI83871C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (2) GR3000177T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (2) IE63631B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL80320A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO165840C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ217959A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (2) PH24902A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT83573B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DE3686723T2 (de) 1985-10-17 1993-04-01 Novonordisk As Oxadiazolylacetonitrile, ihre herstellung und anwendung.
DK155524C (da) * 1987-03-18 1989-09-11 Ferrosan As Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse
DK522187D0 (da) * 1987-10-06 1987-10-06 Ferrosan As Imidozothienopyrimidiner, deres fremstilling og anvendelse
DK626288D0 (da) * 1988-11-10 1988-11-10 Ferrosan As Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen
DK443589D0 (da) * 1989-09-08 1989-09-08 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK151890D0 (da) * 1990-06-22 1990-06-22 Ferrosan As Heterocykliske forbindelser deres fremstilling og brug
DK204291D0 (da) * 1991-12-20 1991-12-20 Novo Nordisk As Heterocykliske forbindelser deres fremstilling og anvendelse
US5371080A (en) * 1990-06-22 1994-12-06 Novo Nordisk A/S Imidazoquinazoline compounds and their use
US5276028A (en) * 1990-06-22 1994-01-04 Nordisk A/S Imidazoquinoxaline compounds
AU8396491A (en) * 1990-09-04 1992-03-30 Upjohn Company, The Oxygenated quinoxalines
AU4035893A (en) * 1991-12-17 1993-07-19 Upjohn Company, The 3-substituted imidazo (1,5-a) and imidazo (1,5-a)-triazolo (1,5-c) quinoxalines and quinazolines with cns activity
FI101305B (fi) * 1996-03-18 1998-05-29 Map Medical Technologies Oy Radiofarmaseuttisena aineena käyttökelpoiset radiojodatut bentsodiatse piini-johdannaiset ja niiden käyttö diagnostiikassa

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374988A (en) * 1981-11-05 1983-02-22 American Cyanamid Company 4-Heteroarylimidazo-[1,5-A]pyrimidines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DE3686723T2 (de) 1985-10-17 1993-04-01 Novonordisk As Oxadiazolylacetonitrile, ihre herstellung und anwendung.

Also Published As

Publication number Publication date
PT83573B (pt) 1988-10-14
KR940010035B1 (ko) 1994-10-21
EP0274009A1 (en) 1988-07-13
GR3006440T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-21
JPH0751577B2 (ja) 1995-06-05
IE862734L (en) 1987-04-17
CA1297099C (en) 1992-03-10
ATE80392T1 (de) 1992-09-15
DE3664211D1 (en) 1989-08-10
ES2011448B3 (es) 1990-01-16
EP0226282A2 (en) 1987-06-24
JPH072727B2 (ja) 1995-01-18
JPS62167782A (ja) 1987-07-24
FI83871B (fi) 1991-05-31
ATE44381T1 (de) 1989-07-15
FI864126A7 (fi) 1987-04-18
DK499586D0 (da) 1986-10-17
PH24902A (en) 1990-12-26
NO864063L (no) 1987-04-21
NO165840C (no) 1991-04-17
DK155007C (da) 1989-06-05
NZ217959A (en) 1989-02-24
EP0226282B1 (en) 1989-07-05
GR3000177T3 (en) 1990-12-31
EP0226282A3 (en) 1987-09-16
PT83573A (en) 1986-11-01
FI864126A0 (fi) 1986-10-13
DK155007B (da) 1989-01-23
DK499586A (da) 1987-04-18
IE59830B1 (en) 1994-04-20
FI83871C (fi) 1991-09-10
PH25034A (en) 1991-01-28
DE3686723T2 (de) 1993-04-01
AU6418086A (en) 1987-04-30
EP0274009B1 (en) 1992-09-09
IL80320A (en) 1990-02-09
KR870004033A (ko) 1987-05-07
JPH06192242A (ja) 1994-07-12
AU586043B2 (en) 1989-06-29
NO864063D0 (no) 1986-10-13
DE3686723D1 (de) 1992-10-15
NO165840B (no) 1991-01-07

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