IE60658B1 - The use of ethylene oxide/propylene oxide block copolymers for controlling foam in liquid pharmaceutical formulations - Google Patents
The use of ethylene oxide/propylene oxide block copolymers for controlling foam in liquid pharmaceutical formulationsInfo
- Publication number
- IE60658B1 IE60658B1 IE142987A IE142987A IE60658B1 IE 60658 B1 IE60658 B1 IE 60658B1 IE 142987 A IE142987 A IE 142987A IE 142987 A IE142987 A IE 142987A IE 60658 B1 IE60658 B1 IE 60658B1
- Authority
- IE
- Ireland
- Prior art keywords
- block copolymers
- liquid pharmaceutical
- ethylene oxide
- pharmaceutical formulations
- propylene oxide
- Prior art date
Links
- 239000006260 foam Substances 0.000 title claims abstract description 14
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 title claims abstract description 12
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 229920001400 block copolymer Polymers 0.000 title claims abstract description 12
- 239000007788 liquid Substances 0.000 title claims abstract description 8
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 7
- 229920001451 polypropylene glycol Polymers 0.000 claims description 16
- 238000007911 parenteral administration Methods 0.000 claims description 4
- 229930186147 Cephalosporin Natural products 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims description 2
- WHRVRSCEWKLAHX-LQDWTQKMSA-N benzylpenicillin procaine Chemical compound [H+].CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 WHRVRSCEWKLAHX-LQDWTQKMSA-N 0.000 claims description 2
- 229940124587 cephalosporin Drugs 0.000 claims description 2
- 150000001780 cephalosporins Chemical class 0.000 claims description 2
- 150000002960 penicillins Chemical class 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229940095783 procaine benzylpenicillin Drugs 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000002518 antifoaming agent Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229960001139 cefazolin Drugs 0.000 description 2
- MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 238000005470 impregnation Methods 0.000 description 2
- 239000012669 liquid formulation Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000009516 primary packaging Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- RKTNPKZEPLCLSF-QHBKFCFHSA-N cefpirome sulfate Chemical compound OS(O)(=O)=O.N([C@@H]1C(N2C(=C(C[N+]=3C=4CCCC=4C=CC=3)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 RKTNPKZEPLCLSF-QHBKFCFHSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000004851 dishwashing Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- -1 for example Polymers 0.000 description 1
- 238000004900 laundering Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyethers (AREA)
- Professional, Industrial, Or Sporting Protective Garments (AREA)
- Display Devices Of Pinball Game Machines (AREA)
- Jib Cranes (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3618217A DE3618217C1 (de) | 1986-05-30 | 1986-05-30 | Verwendung von AEthylenoxid-Propylenoxid-Blockpolymeren zur Schaumkontrolle in fluessigen Arzneizubereitungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE871429L IE871429L (en) | 1987-11-30 |
| IE60658B1 true IE60658B1 (en) | 1994-08-10 |
Family
ID=6301946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE142987A IE60658B1 (en) | 1986-05-30 | 1987-05-29 | The use of ethylene oxide/propylene oxide block copolymers for controlling foam in liquid pharmaceutical formulations |
Country Status (24)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060083733A1 (en) * | 2002-01-18 | 2006-04-20 | Fumihide Nishio | High-concentration preparation of soluble thrombomodulin |
| DE102010048948A1 (de) | 2010-10-19 | 2011-12-29 | Clariant International Ltd. | Lagerstabile, wasserbasierende Entschäumeremulsionen |
| DE102018220624A1 (de) | 2018-11-29 | 2020-06-04 | B. Braun Melsungen Ag | Wässrige Zusammensetzung, insbesondere zur Behandlung von Schleimhaut und/oder Wunden |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3142628A (en) * | 1964-07-28 | Process of reducing foam in submerges | ||
| DE925375C (de) * | 1949-08-03 | 1955-03-21 | Upjohn Co | Verfahren zur Herstellung eines Procain-Penicillin-G-Praeparates |
| US2937104A (en) * | 1958-08-18 | 1960-05-17 | Stephan John Thomas | Polymeric alkylene-oxide defoamer material for alkaline aqueous adhesive solutions and the like |
| JPS5416568B2 (enrdf_load_stackoverflow) * | 1972-09-29 | 1979-06-23 | ||
| US4104033A (en) * | 1975-09-12 | 1978-08-01 | Drew Chemical Corporation | Foam prevention in sodium carbonate crystallization |
| GB2067533B (en) * | 1980-01-15 | 1983-07-13 | Exxon Research Engineering Co | Defoaming acid gas scrubbing solutions |
| US4533542A (en) * | 1983-08-22 | 1985-08-06 | Eli Lilly And Company | Pharmaceutical compositions for storage in plastic containers and process therefor |
-
1986
- 1986-05-30 DE DE3618217A patent/DE3618217C1/de not_active Expired
-
1987
- 1987-05-26 AT AT87107677T patent/ATE59783T1/de not_active IP Right Cessation
- 1987-05-26 ES ES198787107677T patent/ES2036544T3/es not_active Expired - Lifetime
- 1987-05-26 EP EP87107677A patent/EP0247584B1/de not_active Expired - Lifetime
- 1987-05-26 DE DE8787107677T patent/DE3767215D1/de not_active Expired - Lifetime
- 1987-05-27 MY MYPI87000742A patent/MY102448A/en unknown
- 1987-05-28 NZ NZ220479A patent/NZ220479A/xx unknown
- 1987-05-28 PH PH35316A patent/PH24473A/en unknown
- 1987-05-28 DD DD87303274A patent/DD266026A5/de not_active IP Right Cessation
- 1987-05-28 FI FI872381A patent/FI88871C/fi not_active IP Right Cessation
- 1987-05-28 MA MA21227A patent/MA20988A1/fr unknown
- 1987-05-28 CS CS873893A patent/CS268831B2/cs not_active IP Right Cessation
- 1987-05-29 IL IL82700A patent/IL82700A/xx not_active IP Right Cessation
- 1987-05-29 JP JP62131929A patent/JPS62289529A/ja active Pending
- 1987-05-29 KR KR1019870005376A patent/KR970005334B1/ko not_active Expired - Lifetime
- 1987-05-29 PT PT84970A patent/PT84970B/pt unknown
- 1987-05-29 IE IE142987A patent/IE60658B1/en not_active IP Right Cessation
- 1987-05-29 DK DK274787A patent/DK167211B1/da not_active IP Right Cessation
- 1987-05-29 ZA ZA873878A patent/ZA873878B/xx unknown
- 1987-05-29 NO NO872265A patent/NO175844C/no unknown
- 1987-05-29 CA CA000538397A patent/CA1322170C/en not_active Expired - Lifetime
- 1987-05-29 AU AU73643/87A patent/AU599658B2/en not_active Expired
- 1987-05-29 HU HU872489A patent/HU196311B/hu unknown
-
1991
- 1991-03-15 GR GR91400062T patent/GR3001614T3/el unknown
-
1995
- 1995-06-01 HK HK86895A patent/HK86895A/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1339430B1 (en) | Freeze-dried pantoprazole preparation and pantoprazole injection | |
| CA2140347A1 (en) | Injection and injection kit containing omeprazole and its analogs | |
| EP0814748A1 (en) | Barrier packaging and materials therefor | |
| US3914419A (en) | Two compartment one unit consecutively injectable liquid vitamin package | |
| IE60658B1 (en) | The use of ethylene oxide/propylene oxide block copolymers for controlling foam in liquid pharmaceutical formulations | |
| US2897120A (en) | Low viscosity cmc pharmaceutical vehicle | |
| US4477452A (en) | Composition of matter comprising a lyophilized preparation of a penicillin derivative | |
| SK72795A3 (en) | Light redispergable and chemical stable pharmaceutical agent containing cefixim | |
| US4534977A (en) | Composition of matter comprising a low bulk density lyophilized preparation of Sodium Piperacillin | |
| AU707220B2 (en) | Pharmaceutical composition for parenteral application containing an indole-carboxylic acid | |
| US3634586A (en) | Stable aqueous suspensions of ampicillin | |
| EP0169700B1 (en) | Improved pharmaceutical formulations for ceftazidime | |
| EP0052962B1 (en) | Pharmaceutical compositions containing two beta-lactam derivatives | |
| JPH0647536B2 (ja) | トコフエロ−ル類含有液剤 | |
| JPH08245382A (ja) | 点眼液 | |
| EP1829545B1 (en) | Prostaglandin f2 alpha derivative containing products | |
| JPH08175998A (ja) | シリコート容器を用いた凍結乾燥製剤 | |
| AU2006235847C1 (en) | Lyophilized pantoprazole preparation | |
| WO2000044333A3 (en) | Novel injectable antimalarial compositions of artemisinin | |
| GB2217202A (en) | Trimelamol-containing pharmaceutical compositions | |
| CA2243528A1 (en) | Medicament forms constituted in situ for releasing enzymes into wounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Patent expired |