WO2000044333A3 - Novel injectable antimalarial compositions of artemisinin - Google Patents

Novel injectable antimalarial compositions of artemisinin Download PDF

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Publication number
WO2000044333A3
WO2000044333A3 PCT/IN2000/000002 IN0000002W WO0044333A3 WO 2000044333 A3 WO2000044333 A3 WO 2000044333A3 IN 0000002 W IN0000002 W IN 0000002W WO 0044333 A3 WO0044333 A3 WO 0044333A3
Authority
WO
WIPO (PCT)
Prior art keywords
artemisinin
antimalarial
novel injectable
formula
composition
Prior art date
Application number
PCT/IN2000/000002
Other languages
French (fr)
Other versions
WO2000044333A2 (en
Inventor
Dinesh Shantilal Patel
Shashikant Prabhudas Kurani
Original Assignee
Dinesh Shantilal Patel
Shashikant Prabhudas Kurani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dinesh Shantilal Patel, Shashikant Prabhudas Kurani filed Critical Dinesh Shantilal Patel
Priority to AU46092/00A priority Critical patent/AU4609200A/en
Publication of WO2000044333A2 publication Critical patent/WO2000044333A2/en
Publication of WO2000044333A3 publication Critical patent/WO2000044333A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A novel injectable antimalarial composition comprising from 5 to 9 % (w/v) of an antimalarial active material of general formula (I) where R is selected from oxygen, -OCH3, -OCH2CH3, formula (1) (where X is selected from Na, K and NH4) and -O-COCH2CH2COOY (where Y is selected from Na, K and NH4); optionally in the presence of other antimalarials in solution with 2.5-di-O-methyl-1.4; 3.6-dianhydro-D-glucitol having formula (VI). The composition is in limpid liquid form in ready to use single or multi dose containers for intravenous therapeutic applications.
PCT/IN2000/000002 1999-01-28 2000-01-03 Novel injectable antimalarial compositions of artemisinin WO2000044333A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU46092/00A AU4609200A (en) 1999-01-28 2000-01-03 Novel injectable antimalarial compositions of artemisinin

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN64/BOM/99 1999-01-28
IN64BO1999 1999-01-28
IN738BO1999 1999-10-29
IN738/BOM/99 1999-10-29

Publications (2)

Publication Number Publication Date
WO2000044333A2 WO2000044333A2 (en) 2000-08-03
WO2000044333A3 true WO2000044333A3 (en) 2001-11-01

Family

ID=26324139

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2000/000002 WO2000044333A2 (en) 1999-01-28 2000-01-03 Novel injectable antimalarial compositions of artemisinin

Country Status (2)

Country Link
AU (1) AU4609200A (en)
WO (1) WO2000044333A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105963244A (en) * 2016-01-15 2016-09-28 赵鸣 Injection artesunate formulation and application thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2984A (en) * 2009-01-14 2014-09-30 Lincoln Pharmaceutical Ltd An arteether injection for treatment of malaria

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN85108105A (en) * 1985-10-17 1987-04-22 国家医药管理局上海医药工业研究院 The preparation method of artemisia apiacea ester for injection
EP0359184A1 (en) * 1988-09-12 1990-03-21 Bristol-Myers Squibb Company Etoposide solutions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN85108105A (en) * 1985-10-17 1987-04-22 国家医药管理局上海医药工业研究院 The preparation method of artemisia apiacea ester for injection
EP0359184A1 (en) * 1988-09-12 1990-03-21 Bristol-Myers Squibb Company Etoposide solutions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 108, no. 26, 27 June 1988, Columbus, Ohio, US; abstract no. 226883a, D. WANG ET AL.: "preparation of artesunate injections" page 334; column 1; XP002149043 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105963244A (en) * 2016-01-15 2016-09-28 赵鸣 Injection artesunate formulation and application thereof

Also Published As

Publication number Publication date
WO2000044333A2 (en) 2000-08-03
AU4609200A (en) 2000-08-18

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