CA1322170C - Use of ethylene oxide/propylene oxide block copolymers for controlling foam in liquid pharmaceutical formulations, pharmaceutical formulations, and a process for their preparation - Google Patents

Use of ethylene oxide/propylene oxide block copolymers for controlling foam in liquid pharmaceutical formulations, pharmaceutical formulations, and a process for their preparation

Info

Publication number
CA1322170C
CA1322170C CA000538397A CA538397A CA1322170C CA 1322170 C CA1322170 C CA 1322170C CA 000538397 A CA000538397 A CA 000538397A CA 538397 A CA538397 A CA 538397A CA 1322170 C CA1322170 C CA 1322170C
Authority
CA
Canada
Prior art keywords
liquid pharmaceutical
ethylene oxide
propylene oxide
pharmaceutical formulations
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000538397A
Other languages
English (en)
French (fr)
Inventor
Karl-Detlef Schwabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of CA1322170C publication Critical patent/CA1322170C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Jib Cranes (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
CA000538397A 1986-05-30 1987-05-29 Use of ethylene oxide/propylene oxide block copolymers for controlling foam in liquid pharmaceutical formulations, pharmaceutical formulations, and a process for their preparation Expired - Lifetime CA1322170C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3618217A DE3618217C1 (de) 1986-05-30 1986-05-30 Verwendung von AEthylenoxid-Propylenoxid-Blockpolymeren zur Schaumkontrolle in fluessigen Arzneizubereitungen
DEP3618217.6 1986-05-30

Publications (1)

Publication Number Publication Date
CA1322170C true CA1322170C (en) 1993-09-14

Family

ID=6301946

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000538397A Expired - Lifetime CA1322170C (en) 1986-05-30 1987-05-29 Use of ethylene oxide/propylene oxide block copolymers for controlling foam in liquid pharmaceutical formulations, pharmaceutical formulations, and a process for their preparation

Country Status (24)

Country Link
EP (1) EP0247584B1 (enrdf_load_stackoverflow)
JP (1) JPS62289529A (enrdf_load_stackoverflow)
KR (1) KR970005334B1 (enrdf_load_stackoverflow)
AT (1) ATE59783T1 (enrdf_load_stackoverflow)
AU (1) AU599658B2 (enrdf_load_stackoverflow)
CA (1) CA1322170C (enrdf_load_stackoverflow)
CS (1) CS268831B2 (enrdf_load_stackoverflow)
DD (1) DD266026A5 (enrdf_load_stackoverflow)
DE (2) DE3618217C1 (enrdf_load_stackoverflow)
DK (1) DK167211B1 (enrdf_load_stackoverflow)
ES (1) ES2036544T3 (enrdf_load_stackoverflow)
FI (1) FI88871C (enrdf_load_stackoverflow)
GR (1) GR3001614T3 (enrdf_load_stackoverflow)
HK (1) HK86895A (enrdf_load_stackoverflow)
HU (1) HU196311B (enrdf_load_stackoverflow)
IE (1) IE60658B1 (enrdf_load_stackoverflow)
IL (1) IL82700A (enrdf_load_stackoverflow)
MA (1) MA20988A1 (enrdf_load_stackoverflow)
MY (1) MY102448A (enrdf_load_stackoverflow)
NO (1) NO175844C (enrdf_load_stackoverflow)
NZ (1) NZ220479A (enrdf_load_stackoverflow)
PH (1) PH24473A (enrdf_load_stackoverflow)
PT (1) PT84970B (enrdf_load_stackoverflow)
ZA (1) ZA873878B (enrdf_load_stackoverflow)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060083733A1 (en) * 2002-01-18 2006-04-20 Fumihide Nishio High-concentration preparation of soluble thrombomodulin
DE102010048948A1 (de) 2010-10-19 2011-12-29 Clariant International Ltd. Lagerstabile, wasserbasierende Entschäumeremulsionen
DE102018220624A1 (de) 2018-11-29 2020-06-04 B. Braun Melsungen Ag Wässrige Zusammensetzung, insbesondere zur Behandlung von Schleimhaut und/oder Wunden

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3142628A (en) * 1964-07-28 Process of reducing foam in submerges
DE925375C (de) * 1949-08-03 1955-03-21 Upjohn Co Verfahren zur Herstellung eines Procain-Penicillin-G-Praeparates
US2937104A (en) * 1958-08-18 1960-05-17 Stephan John Thomas Polymeric alkylene-oxide defoamer material for alkaline aqueous adhesive solutions and the like
JPS5416568B2 (enrdf_load_stackoverflow) * 1972-09-29 1979-06-23
US4104033A (en) * 1975-09-12 1978-08-01 Drew Chemical Corporation Foam prevention in sodium carbonate crystallization
GB2067533B (en) * 1980-01-15 1983-07-13 Exxon Research Engineering Co Defoaming acid gas scrubbing solutions
US4533542A (en) * 1983-08-22 1985-08-06 Eli Lilly And Company Pharmaceutical compositions for storage in plastic containers and process therefor

Also Published As

Publication number Publication date
NO872265D0 (no) 1987-05-29
HUT44179A (en) 1988-02-29
DE3618217C1 (de) 1987-08-06
NO175844B (enrdf_load_stackoverflow) 1994-09-12
FI872381A0 (fi) 1987-05-28
DE3767215D1 (de) 1991-02-14
AU599658B2 (en) 1990-07-26
DD266026A5 (de) 1989-03-22
EP0247584A2 (de) 1987-12-02
ZA873878B (en) 1988-01-27
KR970005334B1 (ko) 1997-04-15
NO872265L (no) 1987-12-01
NO175844C (no) 1994-12-21
NZ220479A (en) 1989-03-29
CS389387A2 (en) 1989-08-14
IE60658B1 (en) 1994-08-10
MY102448A (en) 1992-06-30
EP0247584B1 (de) 1991-01-09
DK274787A (da) 1987-12-01
EP0247584A3 (en) 1988-10-12
FI872381L (fi) 1987-12-01
ES2036544T3 (es) 1993-06-01
JPS62289529A (ja) 1987-12-16
PT84970A (de) 1987-06-01
PT84970B (pt) 1990-02-08
HK86895A (en) 1995-06-09
DK167211B1 (da) 1993-09-20
HU196311B (en) 1988-11-28
GR3001614T3 (en) 1992-11-23
ATE59783T1 (de) 1991-01-15
CS268831B2 (en) 1990-04-11
KR870010873A (ko) 1987-12-18
MA20988A1 (fr) 1987-12-31
IL82700A0 (en) 1987-11-30
FI88871B (fi) 1993-04-15
FI88871C (fi) 1993-07-26
IE871429L (en) 1987-11-30
DK274787D0 (da) 1987-05-29
AU7364387A (en) 1987-12-03
IL82700A (en) 1991-06-10
PH24473A (en) 1990-07-18

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Legal Events

Date Code Title Description
MKEX Expiry

Effective date: 20100914