IE47749B1 - Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations - Google Patents

Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations

Info

Publication number
IE47749B1
IE47749B1 IE2067/78A IE206778A IE47749B1 IE 47749 B1 IE47749 B1 IE 47749B1 IE 2067/78 A IE2067/78 A IE 2067/78A IE 206778 A IE206778 A IE 206778A IE 47749 B1 IE47749 B1 IE 47749B1
Authority
IE
Ireland
Prior art keywords
formula
imidazole
group
carbon atoms
arylalkylimidazole
Prior art date
Application number
IE2067/78A
Other languages
English (en)
Other versions
IE782067L (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IE782067L publication Critical patent/IE782067L/xx
Publication of IE47749B1 publication Critical patent/IE47749B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IE2067/78A 1977-10-19 1978-10-18 Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations IE47749B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB4353277 1977-10-19
GB4351277 1977-10-19
GB398478 1978-02-01

Publications (2)

Publication Number Publication Date
IE782067L IE782067L (en) 1979-04-19
IE47749B1 true IE47749B1 (en) 1984-06-13

Family

ID=27254350

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2067/78A IE47749B1 (en) 1977-10-19 1978-10-18 Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations

Country Status (12)

Country Link
JP (1) JPS5488268A (enrdf_load_stackoverflow)
AT (1) AT370095B (enrdf_load_stackoverflow)
AU (1) AU522055B2 (enrdf_load_stackoverflow)
CA (1) CA1111433A (enrdf_load_stackoverflow)
DE (1) DE2845406A1 (enrdf_load_stackoverflow)
DK (1) DK464278A (enrdf_load_stackoverflow)
FI (1) FI783175A7 (enrdf_load_stackoverflow)
IE (1) IE47749B1 (enrdf_load_stackoverflow)
IL (1) IL55858A (enrdf_load_stackoverflow)
IT (1) IT1109321B (enrdf_load_stackoverflow)
MC (1) MC1221A1 (enrdf_load_stackoverflow)
ZA (1) ZA785863B (enrdf_load_stackoverflow)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55313A (en) * 1978-06-13 1980-01-05 Kissei Pharmaceut Co Ltd Imidazole derivative
JPS6047257B2 (ja) * 1979-07-19 1985-10-21 旭化成株式会社 新規な塩基性物質およびその製造法
US4430445A (en) 1979-07-19 1984-02-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel basic imidazolylmethylstyrene compound, its polymer, a process for the preparation thereof and a use as ion exchange resin
JPS5681566A (en) * 1979-12-05 1981-07-03 Yoshitomi Pharmaceut Ind Ltd Imidazole derivative
GR78234B (enrdf_load_stackoverflow) * 1981-03-10 1984-09-26 Ciba Geigy Ag
JPS57188570A (en) * 1981-05-14 1982-11-19 Shionogi & Co Ltd Benzylazole derivative
ZA835967B (en) * 1982-08-14 1985-04-24 Wellcome Found Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations
US4581370A (en) * 1983-07-12 1986-04-08 Schering A.G. Antiarrhythmic imidazoliums
JPH0172006U (enrdf_load_stackoverflow) * 1987-10-31 1989-05-15
JPH01316365A (ja) * 1988-03-24 1989-12-21 Shikoku Chem Corp １−ベンジルイミダゾール化合物、該化合物の合成方法及び該化合物を用いるポリエポキシ樹脂の硬化方法

Also Published As

Publication number Publication date
AU522055B2 (en) 1982-05-13
JPS6233227B2 (enrdf_load_stackoverflow) 1987-07-20
MC1221A1 (fr) 1979-07-20
IT1109321B (it) 1985-12-16
DK464278A (da) 1979-04-20
ZA785863B (en) 1980-05-28
IL55858A (en) 1982-09-30
IE782067L (en) 1979-04-19
DE2845406A1 (de) 1979-05-03
AT370095B (de) 1983-02-25
IL55858A0 (en) 1979-01-31
IT7851570A0 (it) 1978-10-18
ATA747378A (de) 1982-07-15
FI783175A7 (fi) 1979-04-20
CA1111433A (en) 1981-10-27
JPS5488268A (en) 1979-07-13
AU4082478A (en) 1980-04-24

Similar Documents

Publication Publication Date Title
EP0003732B1 (en) Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
EP0000951B1 (en) Pharmaceutical formulations comprising 1-substituted imidazoles, 1-substituted imidazoles and 1-substituted imidazoles for use in the treatment or prophylaxis of thrombo-embolic disorders
JP2000516223A (ja) チエノピリミジン類
IE47749B1 (en) Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations
SA109300394B1 (ar) ثيازوليل- وأوكسازوليل- أيزوكوينولينونات وطرق لاستخدامها
US4328234A (en) Imidazole derivatives and salts thereof and pharmaceutical formulations useful in thrombo-embolic disorders
US4748180A (en) β-carboline-3-carboxylic acid derivatives, and their use as psychotropic and anti-epileptic agents
EP0000950B1 (en) Imidazole derivatives and salts thereof and their synthesis
US4357340A (en) Imidazole derivatives and angina pectoris
US4431815A (en) 1-[3-(2,4-Dichlorophenyl)propyl]imidazole and salts thereof
US4396771A (en) Imidazole derivatives and salts thereof
US4405634A (en) Imidazole derivatives for treating myocardial infarction
US4425354A (en) Imidazole derivatives and salts thereof, their synthesis, and intermediates, and pharmaceutical formulations
US4317830A (en) Treatment of shock
NZ188693A (en) 1-arylalkylimidazoles and pharmaceutical compositions
EP0106060B1 (en) Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations
KR820001911B1 (ko) 이미다졸 유도체의 제조방법
KR820001912B1 (ko) 이미다졸류의 제법
HU181992B (hu) Eljárás imidazol-származékok és sóik előállítására
KR830000614B1 (ko) 이미다졸 유도체의 제조방법
IE47650B1 (en) Pharmaceutical formulations comprising imidazole derivatives and salts
AT377515B (de) Verfahren zum herstellen von neuen 1-arylalkyl-imidazolderivaten und deren salzen
NZ228286A (en) Quinolin-2,5-diones