IE45613L - Cephalosporins. - Google Patents

Cephalosporins.

Info

Publication number
IE45613L
IE45613L IE771969A IE196977A IE45613L IE 45613 L IE45613 L IE 45613L IE 771969 A IE771969 A IE 771969A IE 196977 A IE196977 A IE 196977A IE 45613 L IE45613 L IE 45613L
Authority
IE
Ireland
Prior art keywords
formula
compound
gb1572201a
ylthiomethyl
cephem
Prior art date
Application number
IE771969A
Other versions
IE45613B1 (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/784,885 external-priority patent/US4082912A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to IE269/81A priority Critical patent/IE45614B1/en
Publication of IE45613L publication Critical patent/IE45613L/en
Publication of IE45613B1 publication Critical patent/IE45613B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

New amino-3-(2-carboxyalkyl-2,3-dihydro-3-oxo-s-triazolo[4,3-b]pyridazin-6 -ylthiomethyl)-3-cephem-4-carboxylic acids of formula I, their salts and their easily hydrolysed esters of the 4-carboxyl group are prepared. The synthesis consists in reacting a compound of formula III with a compound of formula IV and then treating the product obtained with an acylating agent R<2>-X. The compounds of the invention are powerful antibacterial agents which have a good solubility in water. <IMAGE> [GB1572201A]
IE1969/77A 1977-04-05 1977-09-27 Cephalosporins IE45613B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE269/81A IE45614B1 (en) 1977-04-05 1977-09-27 Cephalosporins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/784,885 US4082912A (en) 1976-06-30 1977-04-05 Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylmethyl)-3-cephem-4-carboxylic acids their salts and easily hydrolyzed esters

Publications (2)

Publication Number Publication Date
IE45613L true IE45613L (en) 1978-10-05
IE45613B1 IE45613B1 (en) 1982-10-06

Family

ID=25133827

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1969/77A IE45613B1 (en) 1977-04-05 1977-09-27 Cephalosporins

Country Status (17)

Country Link
JP (1) JPS53124290A (en)
AU (1) AU517919B2 (en)
BE (1) BE859774A (en)
CA (1) CA1113455A (en)
CH (1) CH627184A5 (en)
DE (1) DE2807847A1 (en)
DK (1) DK145497C (en)
FI (1) FI60869C (en)
FR (1) FR2408614A1 (en)
GB (1) GB1572201A (en)
GR (1) GR73550B (en)
IE (1) IE45613B1 (en)
LU (1) LU78323A1 (en)
NL (1) NL7711644A (en)
SE (1) SE425491B (en)
YU (1) YU247977A (en)
ZA (1) ZA775781B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3000377A1 (en) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim NEW SULPHONAMIDES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
CN114940665B (en) * 2022-06-10 2024-05-07 河南省科学院高新技术研究中心 Benzisothiazolinone compound serving as bactericide and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907786A (en) * 1973-09-04 1975-09-23 Bristol Myers Co 7-{8 {60 -(2-aminomethyl-1,4-cyclohexadienyl)acetamido{9 -3-heterocyclic-thiomethyl-3-cephem-4-carboxylic acids and salts
US3946000A (en) * 1973-10-31 1976-03-23 Bristol-Myers Company 7-[α-(2-Aminomethyl-1-cyclohexenyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids

Also Published As

Publication number Publication date
NL7711644A (en) 1978-10-09
FI60869B (en) 1981-12-31
SE7710823L (en) 1978-10-06
CA1113455A (en) 1981-12-01
ZA775781B (en) 1978-08-30
FI772860A (en) 1978-10-06
IE45613B1 (en) 1982-10-06
CH627184A5 (en) 1981-12-31
BE859774A (en) 1978-04-14
FR2408614B1 (en) 1980-12-05
GB1572201A (en) 1980-07-23
JPS53124290A (en) 1978-10-30
DK429577A (en) 1978-10-06
FR2408614A1 (en) 1979-06-08
DK145497C (en) 1983-05-02
AU2932877A (en) 1979-04-12
GR73550B (en) 1984-03-13
LU78323A1 (en) 1978-06-12
SE425491B (en) 1982-10-04
DK145497B (en) 1982-11-29
DE2807847A1 (en) 1978-10-19
YU247977A (en) 1982-10-31
AU517919B2 (en) 1981-09-03
FI60869C (en) 1982-04-13

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