JPS5770893A - Preparation of cephalosporin derivative - Google Patents

Preparation of cephalosporin derivative

Info

Publication number
JPS5770893A
JPS5770893A JP14517680A JP14517680A JPS5770893A JP S5770893 A JPS5770893 A JP S5770893A JP 14517680 A JP14517680 A JP 14517680A JP 14517680 A JP14517680 A JP 14517680A JP S5770893 A JPS5770893 A JP S5770893A
Authority
JP
Japan
Prior art keywords
salt
compound
cephem
expressed
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14517680A
Other languages
Japanese (ja)
Inventor
Takashi Kamiya
Hitoshi Nakamura
Satoshi Hirabayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to JP14517680A priority Critical patent/JPS5770893A/en
Publication of JPS5770893A publication Critical patent/JPS5770893A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a synthetic intermediate for an antimicrobial agent or substance easily under mild conditions, by reducing a 3- cephem-4-carboxylic acid derivative or a salt thereof with a trivalent titanium compound.
CONSTITUTION: A 3-cephem-4-carboxylic acid derivative expressed by formulaI [R1 is amino or acylamino; R2 is halogen or nucleophilie compound residue, e.g. acyloxy; R3 is carboxy or protected carboxyl or a salt thereof is reduced with a trivalent titanium compound, e.g. titanium chloride, to give a cepham compound expressed by formula II or a salt thereof and (or) a 3-cephem compound expressed by formula III or a salt thereof. The reaction is carried out frequently in the presence of a solvent, e.g. chloroform, usually under cooling in a nitrogen stream advantageously at a pH of 7W8.
COPYRIGHT: (C)1982,JPO&Japio
JP14517680A 1980-10-16 1980-10-16 Preparation of cephalosporin derivative Pending JPS5770893A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14517680A JPS5770893A (en) 1980-10-16 1980-10-16 Preparation of cephalosporin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14517680A JPS5770893A (en) 1980-10-16 1980-10-16 Preparation of cephalosporin derivative

Publications (1)

Publication Number Publication Date
JPS5770893A true JPS5770893A (en) 1982-05-01

Family

ID=15379184

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14517680A Pending JPS5770893A (en) 1980-10-16 1980-10-16 Preparation of cephalosporin derivative

Country Status (1)

Country Link
JP (1) JPS5770893A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4958018A (en) * 1988-05-11 1990-09-18 Otsuka Kagaku Kabushiki Kaisha Method for production of 3-exomethylenecepham derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4958018A (en) * 1988-05-11 1990-09-18 Otsuka Kagaku Kabushiki Kaisha Method for production of 3-exomethylenecepham derivatives

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