JPS5770893A - Preparation of cephalosporin derivative - Google Patents
Preparation of cephalosporin derivativeInfo
- Publication number
- JPS5770893A JPS5770893A JP14517680A JP14517680A JPS5770893A JP S5770893 A JPS5770893 A JP S5770893A JP 14517680 A JP14517680 A JP 14517680A JP 14517680 A JP14517680 A JP 14517680A JP S5770893 A JPS5770893 A JP S5770893A
- Authority
- JP
- Japan
- Prior art keywords
- salt
- compound
- cephem
- expressed
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as a synthetic intermediate for an antimicrobial agent or substance easily under mild conditions, by reducing a 3- cephem-4-carboxylic acid derivative or a salt thereof with a trivalent titanium compound.
CONSTITUTION: A 3-cephem-4-carboxylic acid derivative expressed by formulaI [R1 is amino or acylamino; R2 is halogen or nucleophilie compound residue, e.g. acyloxy; R3 is carboxy or protected carboxyl or a salt thereof is reduced with a trivalent titanium compound, e.g. titanium chloride, to give a cepham compound expressed by formula II or a salt thereof and (or) a 3-cephem compound expressed by formula III or a salt thereof. The reaction is carried out frequently in the presence of a solvent, e.g. chloroform, usually under cooling in a nitrogen stream advantageously at a pH of 7W8.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14517680A JPS5770893A (en) | 1980-10-16 | 1980-10-16 | Preparation of cephalosporin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14517680A JPS5770893A (en) | 1980-10-16 | 1980-10-16 | Preparation of cephalosporin derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5770893A true JPS5770893A (en) | 1982-05-01 |
Family
ID=15379184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14517680A Pending JPS5770893A (en) | 1980-10-16 | 1980-10-16 | Preparation of cephalosporin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5770893A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4958018A (en) * | 1988-05-11 | 1990-09-18 | Otsuka Kagaku Kabushiki Kaisha | Method for production of 3-exomethylenecepham derivatives |
-
1980
- 1980-10-16 JP JP14517680A patent/JPS5770893A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4958018A (en) * | 1988-05-11 | 1990-09-18 | Otsuka Kagaku Kabushiki Kaisha | Method for production of 3-exomethylenecepham derivatives |
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