IE44416B1 - Substituted phenyl amidines - Google Patents

Substituted phenyl amidines

Info

Publication number
IE44416B1
IE44416B1 IE110/77A IE11077A IE44416B1 IE 44416 B1 IE44416 B1 IE 44416B1 IE 110/77 A IE110/77 A IE 110/77A IE 11077 A IE11077 A IE 11077A IE 44416 B1 IE44416 B1 IE 44416B1
Authority
IE
Ireland
Prior art keywords
crl
solution
addition salts
mixture
mol
Prior art date
Application number
IE110/77A
Other languages
English (en)
Other versions
IE44416L (en
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of IE44416L publication Critical patent/IE44416L/xx
Publication of IE44416B1 publication Critical patent/IE44416B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IE110/77A 1976-01-26 1977-01-20 Substituted phenyl amidines IE44416B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2895/76A GB1538097A (en) 1976-01-26 1976-01-26 Substituted phenyl-amidines

Publications (2)

Publication Number Publication Date
IE44416L IE44416L (en) 1977-07-26
IE44416B1 true IE44416B1 (en) 1981-11-18

Family

ID=9748048

Family Applications (1)

Application Number Title Priority Date Filing Date
IE110/77A IE44416B1 (en) 1976-01-26 1977-01-20 Substituted phenyl amidines

Country Status (14)

Country Link
US (1) US4146647A (forum.php)
JP (1) JPS5953895B2 (forum.php)
BE (1) BE850723A (forum.php)
CA (1) CA1074797A (forum.php)
CH (1) CH620901A5 (forum.php)
DE (1) DE2702119C2 (forum.php)
DK (1) DK30277A (forum.php)
ES (1) ES455294A1 (forum.php)
FR (1) FR2338927A1 (forum.php)
GB (1) GB1538097A (forum.php)
IE (1) IE44416B1 (forum.php)
LU (1) LU76641A1 (forum.php)
NL (1) NL188573C (forum.php)
SE (1) SE440501B (forum.php)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH630606A5 (en) * 1977-02-15 1982-06-30 Lafon Labor Phenylamidine derivatives useful especially in therapeutics
EP0011596B1 (de) * 1978-10-09 1981-12-30 Ciba-Geigy Ag Neue 2-(alpha-Phenoxy-alkyl)-imidazoline und ihre Salze, deren Herstellung und Verwendung sowie sie enthaltende Mittel zur Bekämpfung von pflanzenschädlichen und tierparasitären Milben
DE2961996D1 (en) * 1978-11-03 1982-03-11 Bayer Ag N-alkyl-haloacetanilides substituted by an oxime group, processes for their preparation, herbicidal compositions containing them, a process for combating weeds, a process for preparing herbicidal compositions.
US4260626A (en) * 1979-03-26 1981-04-07 Richardson-Merrell Inc. Tetrahydro and imidazoline antisecretory compounds
US4616085A (en) * 1980-06-19 1986-10-07 Petrolite Corporation Thioethers of imidazolines
FR2506764A1 (fr) * 1981-05-26 1982-12-03 Synthelabo Derives d'amidoximes, leur preparation et leur application en therapeutique
US5227484A (en) * 1982-01-14 1993-07-13 Merck Patent Gmbh Anisotropic compounds having nematic phase and liquid crystal mixtures
FR2549049B1 (fr) * 1983-07-13 1986-06-20 Chauvin Blache Lab Nouvelles amidines, leur procede de preparation et leur application therapeutique
US4659363A (en) * 1983-07-25 1987-04-21 Ciba-Geigy Corporation N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
GB9509930D0 (en) * 1995-05-17 1995-07-12 Smithkline Beecham Corp Method for preparing certain acetonitriles
RU2008130455A (ru) * 2006-01-27 2010-03-10 Ф.Хоффманн-Ля Рош Аг (Ch) Применение замещенных производных 2-имидазола или имидазолинов
ATE462696T1 (de) * 2006-10-19 2010-04-15 Hoffmann La Roche Aminomethyl-2-imidazole mit affinität zu mit dem trace-amin assoziierten rezeptoren
MX2009003801A (es) * 2006-10-19 2009-04-22 Hoffmann La Roche Aminometil-4-imidazoles.
JP5064511B2 (ja) * 2006-11-02 2012-10-31 エフ．ホフマン−ラ ロシュ アーゲー 痕跡アミン関連受容体調節剤としての置換２−イミダゾール
WO2008058867A2 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
ES2364701T3 (es) * 2006-12-13 2011-09-12 F. Hoffmann-La Roche Ag Nuevos 2-imidazoles como ligandos para receptores asociados a aminas trazas.
US20080146523A1 (en) * 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
NZ578260A (en) * 2007-02-02 2012-02-24 Hoffmann La Roche Novel 2-aminooxazolines as taar1 ligands for cns disorders
AU2008214774A1 (en) * 2007-02-15 2008-08-21 F. Hoffmann-La Roche Ag 2-aminooxazolines as TAAR1 ligands
JP2010531837A (ja) 2007-07-02 2010-09-30 エフ．ホフマン−ラ ロシュ アーゲー 微量アミン関連レセプター（ｔａａｒ）に対して良好な親和性を有する２−イミダゾリン
JP2010531836A (ja) * 2007-07-03 2010-09-30 エフ．ホフマン−ラ ロシュ アーゲー ４−イミダゾリン及びそれらの抗うつ剤としての使用
EP2183216A1 (en) * 2007-07-27 2010-05-12 F. Hoffmann-Roche AG 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
CN101765425A (zh) * 2007-08-02 2010-06-30 弗·哈夫曼-拉罗切有限公司 苯甲酰胺衍生物用于治疗cns障碍的用途
JP5341084B2 (ja) * 2007-08-03 2013-11-13 エフ．ホフマン−ラ ロシュ アーゲー Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体
CA2728480A1 (en) * 2008-07-24 2010-01-28 F. Hoffmann-La Roche Ag 4,5-dihydro-oxazol-2-yl derivatives
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
WO2013137371A1 (ja) * 2012-03-15 2013-09-19 興和株式会社 新規ピリミジン化合物及びそれらを含有する医薬
CR20180443A (es) 2016-03-17 2018-11-21 Hoffmann La Roche Derivado de morfolina

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE598730A (forum.php) * 1960-01-01
US3115525A (en) * 1960-04-21 1963-12-24 Wassermann S P A Soc It Per Sp Halogen-substituted amidoximes
US3394181A (en) * 1964-06-29 1968-07-23 Sterling Drug Inc Phenoxy-lower-alkyl-amidoximes and phenylamino-lower-alkyl-amidoximes
US3445517A (en) * 1966-06-03 1969-05-20 Lilly Co Eli Aryl acetamidines
FR2036958A6 (forum.php) * 1969-04-23 1970-12-31 Orsymonde
FR2149264B1 (forum.php) * 1971-08-13 1974-09-06 Orsymonde
US3775478A (en) * 1972-05-30 1973-11-27 Dow Chemical Co Substituted phenylthioamidines
FR2207706B1 (forum.php) * 1972-11-24 1975-11-28 Orsymonde
US3939912A (en) * 1975-03-21 1976-02-24 Continental Oil Company Method for reducing the production of water from oil wells

Also Published As

Publication number Publication date
NL7700806A (nl) 1977-07-28
DE2702119A1 (de) 1977-07-28
GB1538097A (en) 1979-01-10
FR2338927A1 (fr) 1977-08-19
JPS52105131A (en) 1977-09-03
CH620901A5 (forum.php) 1980-12-31
ES455294A1 (es) 1978-01-01
NL188573C (nl) 1992-08-03
DE2702119C2 (de) 1986-07-10
FR2338927B1 (forum.php) 1980-10-10
SE7700777L (sv) 1977-07-27
SE440501B (sv) 1985-08-05
CA1074797A (en) 1980-04-01
JPS5953895B2 (ja) 1984-12-27
IE44416L (en) 1977-07-26
DK30277A (da) 1977-07-27
LU76641A1 (forum.php) 1977-06-24
US4146647A (en) 1979-03-27
BE850723A (fr) 1977-05-16

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Legal Events

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MM4A Patent lapsed