IE41474B1 - -thiomethylergolines - Google Patents

-thiomethylergolines

Info

Publication number
IE41474B1
IE41474B1 IE1221/75A IE122175A IE41474B1 IE 41474 B1 IE41474 B1 IE 41474B1 IE 1221/75 A IE1221/75 A IE 1221/75A IE 122175 A IE122175 A IE 122175A IE 41474 B1 IE41474 B1 IE 41474B1
Authority
IE
Ireland
Prior art keywords
methyl
compound
alk
formula
didehydroergoline
Prior art date
Application number
IE1221/75A
Other languages
English (en)
Other versions
IE41474L (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IE41474L publication Critical patent/IE41474L/xx
Publication of IE41474B1 publication Critical patent/IE41474B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IE1221/75A 1974-06-06 1975-06-03 -thiomethylergolines IE41474B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US477136A US3901894A (en) 1974-06-06 1974-06-06 8-thiomethylergolines

Publications (2)

Publication Number Publication Date
IE41474L IE41474L (en) 1975-12-06
IE41474B1 true IE41474B1 (en) 1980-01-16

Family

ID=23894677

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1221/75A IE41474B1 (en) 1974-06-06 1975-06-03 -thiomethylergolines

Country Status (27)

Country Link
US (1) US3901894A (enrdf_load_stackoverflow)
JP (1) JPS582946B2 (enrdf_load_stackoverflow)
AR (1) AR210736A1 (enrdf_load_stackoverflow)
AT (1) AT344333B (enrdf_load_stackoverflow)
AU (1) AU507574B2 (enrdf_load_stackoverflow)
BE (1) BE829887A (enrdf_load_stackoverflow)
BG (1) BG24812A3 (enrdf_load_stackoverflow)
CA (1) CA1071623A (enrdf_load_stackoverflow)
CH (1) CH617196A5 (enrdf_load_stackoverflow)
CS (1) CS199591B2 (enrdf_load_stackoverflow)
DD (1) DD120438A5 (enrdf_load_stackoverflow)
DE (1) DE2524575A1 (enrdf_load_stackoverflow)
DK (1) DK144160C (enrdf_load_stackoverflow)
ES (1) ES438313A1 (enrdf_load_stackoverflow)
FR (1) FR2273542A1 (enrdf_load_stackoverflow)
GB (1) GB1505296A (enrdf_load_stackoverflow)
HU (1) HU173590B (enrdf_load_stackoverflow)
IE (1) IE41474B1 (enrdf_load_stackoverflow)
IL (1) IL47424A (enrdf_load_stackoverflow)
NL (1) NL180911C (enrdf_load_stackoverflow)
PH (1) PH10992A (enrdf_load_stackoverflow)
PL (1) PL95738B1 (enrdf_load_stackoverflow)
RO (1) RO77543A (enrdf_load_stackoverflow)
SE (1) SE420095B (enrdf_load_stackoverflow)
SU (1) SU613724A3 (enrdf_load_stackoverflow)
YU (1) YU145575A (enrdf_load_stackoverflow)
ZA (1) ZA753638B (enrdf_load_stackoverflow)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4147789A (en) * 1974-03-14 1979-04-03 Sandoz Ltd. 6-Methyl-8-thiomethyl-ergolene derivatives
US3959288A (en) * 1974-12-13 1976-05-25 Eli Lilly And Company 8-Oxymethylergolines and process therefor
JPS5283894A (en) * 1976-01-01 1977-07-13 Lilly Co Eli 88thiomethyl ergoline
GB1549829A (en) * 1976-05-26 1979-08-08 Farmaceutici Italia 10'-methoxy-1',6'-dimethylergoline-8'-beta-methyl-amino(or thio)-pyrazines
IT1192260B (it) * 1977-07-05 1988-03-31 Simes Derivati di ergoline-2-tioeteri e loro solfossidi
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4180582A (en) * 1978-02-08 1979-12-25 Eli Lilly And Company 6-n-Propyl-8-methoxy-methyl or methylmercaptomethylergolines and related compounds as prolactin inhibitors and to treat Parkinson's syndrome
US4202979A (en) * 1979-01-11 1980-05-13 Eli Lilly And Company 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4246265A (en) * 1979-10-01 1981-01-20 Eli Lilly And Company 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
FR2526797A1 (fr) * 1982-05-12 1983-11-18 Roussel Uclaf Nouveaux derives de l'acide 9-oxalysergique, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
CH649998A5 (de) * 1982-08-09 1985-06-28 Sandoz Ag Ergolinderivate, ein verfahren zu ihrer herstellung und heilmittel, enthaltend diese ergolinderivate als wirkstoff.
GB8427536D0 (en) * 1984-10-31 1984-12-05 Lilly Industries Ltd Ergoline derivatives
US4675322A (en) * 1984-12-10 1987-06-23 Eli Lilly And Company 1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
FR2589734B1 (fr) * 1985-11-13 1988-09-02 Roussel Uclaf Utilisation de derives de l'ergoline a l'obtention d'un medicament a visee geriatrique
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives
CZ305160B6 (cs) * 2001-06-08 2015-05-27 Ipsen Pharma S.A.S. Chimérické somatostatin-dopaminové analogy
AU2003221494A1 (en) * 2002-03-15 2003-09-29 Antibioticos S.P.A. Process for the synthesis of pergolide
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
HK1213486A1 (zh) 2012-11-01 2016-07-08 Ipsen Pharma S.A.S. 促生长素抑制素类似物及其二聚体
ES2991763T3 (es) 2014-09-25 2024-12-04 Boehringer Ingelheim Vetmedica Gmbh Tratamiento de combinación de inhibidores de SGLT2 y agonistas de dopamina para la prevención de trastornos metabólicos en animales equinos
US20190374534A1 (en) 2018-06-08 2019-12-12 Boehringer Ingelheim Vetmedica Gmbh Liquid pharmaceutical compositions comprising pergolide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE712054A (enrdf_load_stackoverflow) * 1967-03-16 1968-07-15
DE1935556A1 (de) * 1969-07-12 1971-01-21 Hoechst Ag Verfahren zur Herstellung von Lysergol
JPS5012398A (enrdf_load_stackoverflow) * 1973-06-08 1975-02-07

Also Published As

Publication number Publication date
ZA753638B (en) 1977-01-26
DK249975A (da) 1975-12-07
ATA427975A (de) 1977-11-15
AU507574B2 (en) 1980-02-21
PL95738B1 (pl) 1977-11-30
IL47424A0 (en) 1975-08-31
DK144160B (da) 1981-12-28
BG24812A3 (en) 1978-05-12
ES438313A1 (es) 1977-05-16
PH10992A (en) 1977-10-20
CH617196A5 (enrdf_load_stackoverflow) 1980-05-14
AU8182775A (en) 1976-12-09
DE2524575A1 (de) 1975-12-18
NL180911C (nl) 1987-05-18
SE7506327L (sv) 1975-12-08
FR2273542B1 (enrdf_load_stackoverflow) 1978-10-06
FR2273542A1 (fr) 1976-01-02
DD120438A5 (enrdf_load_stackoverflow) 1976-06-12
IE41474L (en) 1975-12-06
BE829887A (fr) 1975-12-05
CA1071623A (en) 1980-02-12
SE420095B (sv) 1981-09-14
SU613724A3 (ru) 1978-06-30
RO77543A (ro) 1982-02-26
US3901894A (en) 1975-08-26
DK144160C (da) 1982-06-07
HU173590B (hu) 1979-06-28
AT344333B (de) 1978-07-10
JPS582946B2 (ja) 1983-01-19
IL47424A (en) 1979-11-30
CS199591B2 (en) 1980-07-31
AR210736A1 (es) 1977-09-15
NL180911B (nl) 1986-12-16
GB1505296A (en) 1978-03-30
NL7506584A (nl) 1975-12-09
JPS50160300A (enrdf_load_stackoverflow) 1975-12-25
YU145575A (en) 1982-02-28

Similar Documents

Publication Publication Date Title
IE41474B1 (en) -thiomethylergolines
US4054660A (en) Method of inhibiting prolactin
US3920664A (en) D-2-halo-6-alkyl-8-substituted ergolines and related compounds
EP0026671B1 (en) Novel ergoline derivatives, compositions containing them, their preparation and use as pharmaceuticals
US4075212A (en) Method of preparing 8,8-disubstituted-6-methylergolines and related compounds
EP0016274B1 (en) 2-azaergolines and 2-aza-8(or 9)-ergolenes, process for their preparation and pharmaceutical compositions containing them
IL42730A (en) D-6-methyl-2,8-disubstituted ergolines,their preparation and pharmaceutical compositions containing them
US3968112A (en) Synthesis of penniclavine and elymoclavine
PL102198B1 (pl) A process of producing the new derivative of 6-methylo-8-methylergoline
US4001242A (en) D-6-methyl-8-formyl-10α-alkoxy-8-ergolene
US3929796A (en) Synthesis of penniclavine and elymoclavine
USRE30219E (en) Method of preparing 8,8-disubstituted-6-methylergolines and related compounds
US4054567A (en) 6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds
US4082753A (en) Penniclavine acetonide
US5079364A (en) T-alkyl ergoline derivatives
US3923812A (en) Synthesis of elymoclavine
USRE30218E (en) 8,8-Disubstituted-6-methylergolines and related compounds
US4098790A (en) Ergoline chlorination process
US4235776A (en) Tetrahydro-2H-benzo[c]pyrroles
US3585201A (en) 10-alkoxy 9,10-dihydro ergoline derivatives
CA1051879A (en) Synthesis of elymoclavine and derivatives
US4075213A (en) 8-Aryl-9-ergolenes
EP0014792B1 (en) Tetrahydro-2h-benzo(c)pyrroles, their preparation, pharmaceutical compositions containing them and the compounds for use as therapeuticals
US4264622A (en) Tetrahydro-2H-benzo[c]pyrroles to inhibit prolactin secretion
KR800000413B1 (ko) 6-메틸-8-(치환)메틸 에르골린류의 제조방법