IE38614B1 - Orally administrable corticosteroid preparations - Google Patents

Info

Publication number

IE38614B1

IE38614B1 IE2216/73A IE221673A IE38614B1 IE 38614 B1 IE38614 B1 IE 38614B1 IE 2216/73 A IE2216/73 A IE 2216/73A IE 221673 A IE221673 A IE 221673A IE 38614 B1 IE38614 B1 IE 38614B1

Authority

IE

Ireland

Prior art keywords

layer

corticosteroid

prednisolone

soluble

taken

Prior art date

1972-12-09

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003246 corticosteroid Substances 0.000 title abstract 7
• 238000002360 preparation method Methods 0.000 title 1
• 229960005205 prednisolone Drugs 0.000 abstract 3
• OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 abstract 3
• 238000010521 absorption reaction Methods 0.000 abstract 2
• 239000011248 coating agent Substances 0.000 abstract 2
• 238000000576 coating method Methods 0.000 abstract 2
• 239000002552 dosage form Substances 0.000 abstract 2
• 150000002148 esters Chemical class 0.000 abstract 2
• 210000004051 gastric juice Anatomy 0.000 abstract 2
• JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
• 239000000203 mixture Substances 0.000 abstract 2
• 150000003839 salts Chemical class 0.000 abstract 2
• FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 abstract 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
• 229920000623 Cellulose acetate phthalate Polymers 0.000 abstract 1
• 101800000414 Corticotropin Proteins 0.000 abstract 1
• 239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 1
• MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 abstract 1
• MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 abstract 1
• ITRJWOMZKQRYTA-RFZYENFJSA-N Cortisone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)CC2=O ITRJWOMZKQRYTA-RFZYENFJSA-N 0.000 abstract 1
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
• FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 abstract 1
• 102100027467 Pro-opiomelanocortin Human genes 0.000 abstract 1
• 239000004480 active ingredient Substances 0.000 abstract 1
• 235000021152 breakfast Nutrition 0.000 abstract 1
• 229940081734 cellulose acetate phthalate Drugs 0.000 abstract 1
• 230000027288 circadian rhythm Effects 0.000 abstract 1
• 238000013270 controlled release Methods 0.000 abstract 1
• IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
• 229960000258 corticotropin Drugs 0.000 abstract 1
• 229960004544 cortisone Drugs 0.000 abstract 1
• 229960003290 cortisone acetate Drugs 0.000 abstract 1
• 229960000890 hydrocortisone Drugs 0.000 abstract 1
• 229960004584 methylprednisolone Drugs 0.000 abstract 1
• 239000008194 pharmaceutical composition Substances 0.000 abstract 1
• 229960004618 prednisone Drugs 0.000 abstract 1
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 abstract 1
• 230000028327 secretion Effects 0.000 abstract 1
• 150000003431 steroids Chemical class 0.000 abstract 1
• 210000002784 stomach Anatomy 0.000 abstract 1
• 230000001360 synchronised effect Effects 0.000 abstract 1