GB1458676A - Orally administrable corticosteroid preparations - Google Patents
Orally administrable corticosteroid preparationsInfo
- Publication number
- GB1458676A GB1458676A GB5709073A GB5709073A GB1458676A GB 1458676 A GB1458676 A GB 1458676A GB 5709073 A GB5709073 A GB 5709073A GB 5709073 A GB5709073 A GB 5709073A GB 1458676 A GB1458676 A GB 1458676A
- Authority
- GB
- United Kingdom
- Prior art keywords
- layer
- corticosteroid
- prednisolone
- soluble
- taken
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1458676 Corticosteroid compositions HOECHST AG 10 Dec 1973 [9 Dec 1972] 57090/73 Heading A5B A controlled release unit dosage pharmaceutical composition for oral administration comprises at least two layers, the word "layer" including a core in its meaning (e.g. drageÚ cores), each comprising a corticosteroid in the form of the free alcohol or an ester or salt thereof and each having different release properties. The corticosteroid may be hydrocortisone, cortisone, prednisone, prednisolone, methylprednisolone, or esters or salts thereof. Each layer may contain the same or different corti- 'costeroids, e.g. prednisolone in one layer and its acetate in another, or cortisone acetate in one layer and prednisolone in another. The preferred form is a dregÚe core such as a pressed tablet as the one corticosteroid-containing layer, having an enteric coat (e.g. cellulose acetate phthalate) resistant to gastric juice but soluble in the dudodenum, and an outer dragÚe coating containing corticosteroid, this coating being freely soluble in gastric juice to liberate its active ingredient for absorption in the stomach. The compositions are intended to enable the corticosteroid to be administered in such a way that its absorption rate and action is synchronised with the circadian rhythm of physiological ACTH secretion, and accordingly, the preferred form provides a small steroid dose immediately (i.e. from the outer, soluble layer), and a larger dose some hours later (i.e. from the inner, enterically coated layer), the dosage form being intended to be taken early in the morning. The invention includes a pack comprising a card carrying at least one pair of inventive unit dosage forms together with instruction that one unit is to be taken at about breakfast time and the other unit is to be taken between midafternoon and bed-time.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2260384A DE2260384C3 (en) | 1972-12-09 | 1972-12-09 | Oral corticosteroid preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1458676A true GB1458676A (en) | 1976-12-15 |
Family
ID=5864005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5709073A Expired GB1458676A (en) | 1972-12-09 | 1973-12-10 | Orally administrable corticosteroid preparations |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS4986527A (en) |
| KR (1) | KR780000243B1 (en) |
| AT (1) | AT345983B (en) |
| BE (1) | BE808442A (en) |
| CA (1) | CA1027864A (en) |
| DE (1) | DE2260384C3 (en) |
| FR (1) | FR2209585B1 (en) |
| GB (1) | GB1458676A (en) |
| HU (1) | HU171907B (en) |
| IE (1) | IE38614B1 (en) |
| IL (1) | IL43764A (en) |
| NL (1) | NL7316585A (en) |
| ZA (1) | ZA739327B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005102271A2 (en) * | 2004-04-22 | 2005-11-03 | Duocort Ab | Pharmaceutical compositions for glucocorticoid replacement therapy |
| WO2010115615A1 (en) * | 2009-04-07 | 2010-10-14 | Duocort Pharma Ab | Improved glucocorticoid therapy |
| US9925139B2 (en) | 2004-04-22 | 2018-03-27 | Acucort Ab | Pharmaceutical compositions for acute glucocorticoid therapy |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1392321T3 (en) * | 2001-03-15 | 2010-11-29 | Soligenix Inc | Process for the treatment of inflammatory diseases of the gastrointestinal tract using topically active corticosteroids |
| UA108360C2 (en) * | 2009-10-01 | 2015-04-27 | SOLID PHARMACEUTICAL COMPOSITION OF CORTICOSTEOIDE DECOMPOSING IN THE ORAL CAVITY | |
| TWI728172B (en) | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | Methods of treating eosinophilic esophagitis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB862376A (en) * | 1957-10-10 | 1961-03-08 | Pfizer & Co C | Sustained release pharmaceutical tablet |
-
1972
- 1972-12-09 DE DE2260384A patent/DE2260384C3/en not_active Expired
-
1973
- 1973-12-03 KR KR7302039A patent/KR780000243B1/en active
- 1973-12-03 FR FR7343036A patent/FR2209585B1/fr not_active Expired
- 1973-12-04 NL NL7316585A patent/NL7316585A/xx not_active Application Discontinuation
- 1973-12-06 CA CA187,580A patent/CA1027864A/en not_active Expired
- 1973-12-06 HU HU73HO00001633A patent/HU171907B/en unknown
- 1973-12-06 IL IL43764A patent/IL43764A/en unknown
- 1973-12-07 AT AT1026773A patent/AT345983B/en active
- 1973-12-07 IE IE2216/73A patent/IE38614B1/en unknown
- 1973-12-07 ZA ZA739327A patent/ZA739327B/en unknown
- 1973-12-08 JP JP48137285A patent/JPS4986527A/ja active Pending
- 1973-12-10 BE BE138701A patent/BE808442A/en unknown
- 1973-12-10 GB GB5709073A patent/GB1458676A/en not_active Expired
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005102271A2 (en) * | 2004-04-22 | 2005-11-03 | Duocort Ab | Pharmaceutical compositions for glucocorticoid replacement therapy |
| WO2005102271A3 (en) * | 2004-04-22 | 2006-08-03 | Duocort Ab | Pharmaceutical compositions for glucocorticoid replacement therapy |
| AU2005235370B2 (en) * | 2004-04-22 | 2011-06-09 | Takeda Pharmaceutical Company Limited | Pharmaceutical compositions for glucocorticoid replacement therapy |
| US8425937B2 (en) | 2004-04-22 | 2013-04-23 | Duocort Pharma Ab | Pharmaceutical compositions for glucocorticoid replacement therapy |
| CN1942176B (en) * | 2004-04-22 | 2013-09-18 | 杜奥科特药物公司 | Pharmaceutical compositions for glucocorticoid replacement therapy |
| CN103006592B (en) * | 2004-04-22 | 2016-03-02 | 杜奥科特药物公司 | For the pharmaceutical composition of glucocorticoid replacement therapy |
| EP3072507A1 (en) * | 2004-04-22 | 2016-09-28 | DuoCort Pharma AB | Pharmaceutical compositions for glucocorticoid replacement therapy |
| US9925139B2 (en) | 2004-04-22 | 2018-03-27 | Acucort Ab | Pharmaceutical compositions for acute glucocorticoid therapy |
| US10583146B2 (en) | 2004-04-22 | 2020-03-10 | Shire Viropharma Incorporated | Pharmaceutical compositions for glucocorticoid replacement therapy |
| WO2010115615A1 (en) * | 2009-04-07 | 2010-10-14 | Duocort Pharma Ab | Improved glucocorticoid therapy |
| CN102448464A (en) * | 2009-04-07 | 2012-05-09 | 杜奥科特药物公司 | Improved glucocorticoid therapy |
Also Published As
| Publication number | Publication date |
|---|---|
| ATA1026773A (en) | 1978-02-15 |
| FR2209585B1 (en) | 1977-09-02 |
| FR2209585A1 (en) | 1974-07-05 |
| IL43764A (en) | 1977-03-31 |
| HU171907B (en) | 1978-04-28 |
| ZA739327B (en) | 1974-10-30 |
| CA1027864A (en) | 1978-03-14 |
| JPS4986527A (en) | 1974-08-19 |
| IE38614L (en) | 1974-06-09 |
| NL7316585A (en) | 1974-06-11 |
| DE2260384A1 (en) | 1974-06-12 |
| DE2260384C3 (en) | 1979-11-29 |
| KR780000243B1 (en) | 1978-07-01 |
| IE38614B1 (en) | 1978-04-26 |
| IL43764A0 (en) | 1974-03-14 |
| DE2260384B2 (en) | 1979-04-12 |
| BE808442A (en) | 1974-06-10 |
| AT345983B (en) | 1978-10-10 |
| AU6328073A (en) | 1975-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |