IE37317B1 - Nitrogen containing isoprenoid compounds - Google Patents

Nitrogen containing isoprenoid compounds

Info

Publication number
IE37317B1
IE37317B1 IE284/73A IE28473A IE37317B1 IE 37317 B1 IE37317 B1 IE 37317B1 IE 284/73 A IE284/73 A IE 284/73A IE 28473 A IE28473 A IE 28473A IE 37317 B1 IE37317 B1 IE 37317B1
Authority
IE
Ireland
Prior art keywords
trimethyldodecatrienyl
benzo
feb
compound
nitrogen containing
Prior art date
Application number
IE284/73A
Other versions
IE37317L (en
Original Assignee
Pierrel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel Spa filed Critical Pierrel Spa
Publication of IE37317L publication Critical patent/IE37317L/en
Publication of IE37317B1 publication Critical patent/IE37317B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Abstract

1387324 Derivative of 1-trimethyldodecatrienylpiperazine PIERREL SPA 21 Feb 1973 [29 Feb 1972] 9348/72 Heading C2C The invention comprises the compound of formula including the stereoisomers, and their pharmaceutically acceptable acid addition salts. In examples, their preparation is effected by reacting either (1) the trimethyldodecatrienyl bromide with 1-(benzo-1,3-dioxal-5-yl)methylpiperazine, or (2) 1-(trimethyldodecatrienyl)piperazine (II) with 1-(benzo-1,3-dioxol-5-yl)methyl chloride. Also prepared are the N-formyl and N-p-tosyl derivatives of II. Therapeutic compositions for oral or parenteral administration comprise the compound of the above formula, which has analgesic and antiinflammatory activity, spasmolytic action of the papaverinic type, and anti-gastric secretion and anti-ulcer activity but with absence of anti-cholinergic properties. [GB1387324A]
IE284/73A 1972-02-29 1973-02-23 Nitrogen containing isoprenoid compounds IE37317B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB934872A GB1387324A (en) 1972-02-29 1972-02-29 Nitrogen containing isoprenoid compounds

Publications (2)

Publication Number Publication Date
IE37317L IE37317L (en) 1973-08-29
IE37317B1 true IE37317B1 (en) 1977-06-22

Family

ID=9870216

Family Applications (1)

Application Number Title Priority Date Filing Date
IE284/73A IE37317B1 (en) 1972-02-29 1973-02-23 Nitrogen containing isoprenoid compounds

Country Status (31)

Country Link
JP (1) JPS5335078B2 (en)
AR (1) AR198301A1 (en)
AT (1) AT333285B (en)
AU (1) AU474791B2 (en)
BE (1) BE796036A (en)
BR (1) BR7301392D0 (en)
CA (1) CA992084A (en)
CH (1) CH569010A5 (en)
CS (2) CS179450B2 (en)
CY (1) CY867A (en)
DE (1) DE2310044A1 (en)
DK (1) DK144012C (en)
ES (1) ES411984A1 (en)
FI (1) FI56178C (en)
FR (1) FR2181757B1 (en)
GB (1) GB1387324A (en)
HK (1) HK51476A (en)
HU (1) HU165112B (en)
IE (1) IE37317B1 (en)
IL (1) IL41662A (en)
IN (1) IN138638B (en)
KE (1) KE2650A (en)
MX (1) MX3448E (en)
MY (1) MY7600279A (en)
NL (1) NL7302525A (en)
NO (1) NO137388C (en)
PL (1) PL92977B1 (en)
RO (2) RO71992A (en)
SE (1) SE397978B (en)
YU (1) YU35366B (en)
ZA (1) ZA731182B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062940B1 (en) * 1993-03-11 1995-06-16 Vita Invest Sa GASTROCINETIC AGENT, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.

Also Published As

Publication number Publication date
NO137388B (en) 1977-11-14
IN138638B (en) 1976-03-06
ATA178473A (en) 1976-03-15
AT333285B (en) 1976-11-10
FR2181757A1 (en) 1973-12-07
CA992084A (en) 1976-06-29
YU49973A (en) 1980-06-30
MY7600279A (en) 1976-12-31
IL41662A0 (en) 1973-05-31
AR198301A1 (en) 1974-06-14
HK51476A (en) 1976-08-20
HU165112B (en) 1974-06-28
JPS4892385A (en) 1973-11-30
AU474791B2 (en) 1976-08-05
DK144012B (en) 1981-11-16
CS179411B2 (en) 1977-10-31
PL92977B1 (en) 1977-04-30
MX3448E (en) 1980-12-02
ES411984A1 (en) 1976-06-16
RO76582A (en) 1981-04-30
CH569010A5 (en) 1975-11-14
FR2181757B1 (en) 1976-12-31
GB1387324A (en) 1975-03-12
JPS5335078B2 (en) 1978-09-25
YU35366B (en) 1980-12-31
BR7301392D0 (en) 1974-08-29
FI56178C (en) 1979-12-10
BE796036A (en) 1973-06-18
CY867A (en) 1976-12-17
RO71992A (en) 1982-09-09
NO137388C (en) 1978-02-22
SE397978B (en) 1977-11-28
DE2310044A1 (en) 1973-09-13
CS179450B2 (en) 1977-10-31
AU5230973A (en) 1974-08-22
FI56178B (en) 1979-08-31
NL7302525A (en) 1973-08-31
KE2650A (en) 1976-07-30
ZA731182B (en) 1974-11-27
DK144012C (en) 1982-04-26
IL41662A (en) 1977-10-31
IE37317L (en) 1973-08-29

Similar Documents

Publication Publication Date Title
IE44166L (en) Nontropine benzilate derivatives.
GB1411583A (en) Aminophenyl-substituted alkyl-heterocyclic derivatives and processes for producing them
GB1187259A (en) New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture
GB1528723A (en) 1-nitro-9-n-substituted aminoalkylamino-acridines their salts and a method of preparing same
IE40335B1 (en) Pyrazole derivatives, process for their preparation and their use as medicaments
GB1301243A (en)
GB1363195A (en) Propenylamine derivatives and process for the production thereof
IE37317B1 (en) Nitrogen containing isoprenoid compounds
GB1276968A (en) Improvements in or relating to phenylacetamides and the preparation thereof
GB1280290A (en) Novel derivatives of benzhydrylpiperazine, their process of preparation and their therapeutic application
GB1394791A (en) Diphenylalkyllactamimide derivatives
GB1114660A (en) Tetrahydro-lsoquinolines
GB1468129A (en) Triazoles and imidazoles
IE36865B1 (en) Imidazolines and process for the preparation thereof
GB1440834A (en) Esters and amides for 3-aryl-1,4-benzodioxan-2-carboxylic acids
GB1361863A (en) Piperazine derivatives their preparation and pharmaceutical compositions containing them
GB1374406A (en) 1-substituted-2- 4,-cinnamyl piperazin-1,-yl methyl- benzimidazoles their process of preparation and their therapeutic application
GB1473971A (en) 3-hydroxy-5,6-benzomorphinan derivatives
GB1325770A (en) Pyrimidopyridazine derivatives
GB1384523A (en) Oxime derivatives and their preparation
GB1324676A (en) Derivatives of 1,7,7-trimethyl-2-norbornane-2-spiro-1,3-dioxolane their process of preparation and their therapeutic application
GB1514225A (en) Paracetamol derivatives
GB1410275A (en) Phenoxycarboxylic acid derivatives their preparation and compositions containing them
IE37932B1 (en) Xylidides
GB1477996A (en) Quinolizine derivatives and their preparation