ES411984A1 - Nitrogen containing isoprenoid compounds - Google Patents

Nitrogen containing isoprenoid compounds

Info

Publication number
ES411984A1
ES411984A1 ES411984A ES411984A ES411984A1 ES 411984 A1 ES411984 A1 ES 411984A1 ES 411984 A ES411984 A ES 411984A ES 411984 A ES411984 A ES 411984A ES 411984 A1 ES411984 A1 ES 411984A1
Authority
ES
Spain
Prior art keywords
cis
trans
isomers
mixture
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES411984A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel SpA filed Critical Pierrel SpA
Publication of ES411984A1 publication Critical patent/ES411984A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Abstract

Procedure for the preparation of acyclic nitrogen-containing isoprenoid compounds, such as N1-piperonyl-N4-3,7,11-trimethyl-2,6,10-dodecatrienyl-piperazine in the form of trans C2-C3, trans C6-C7 isomers, or cis C2-C3, trans C6-C7, or cis C2-C3, cis C6-C7, or trans C2-C3, cis C6-C7, or as a mixture of trans C2-C3, trans C6-C7 isomers and cis C2-C3, trans C6-C7, or as a mixture of cis C2-C3, cis C6-C7 and trans C2-C3, cis C6-C7 isomers, or as a mixture of trans C2-C3 isomers, trans C6-C7 + cis C2-C3, trans C6-C7 + cis C2-C3, cis C6-C7 and therapeutically acceptable acid addition salts, characterized by reacting an acyclic isoprenoid halide with a monosubstituted piperazine, according to the following scheme: **(See formula)** where the group **(See formula)** is conventionally indicated as A and **(See formula)** where Hal = Halogen. (Machine-translation by Google Translate, not legally binding)
ES411984A 1972-02-29 1973-02-23 Nitrogen containing isoprenoid compounds Expired ES411984A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB934872A GB1387324A (en) 1972-02-29 1972-02-29 Nitrogen containing isoprenoid compounds

Publications (1)

Publication Number Publication Date
ES411984A1 true ES411984A1 (en) 1976-06-16

Family

ID=9870216

Family Applications (1)

Application Number Title Priority Date Filing Date
ES411984A Expired ES411984A1 (en) 1972-02-29 1973-02-23 Nitrogen containing isoprenoid compounds

Country Status (31)

Country Link
JP (1) JPS5335078B2 (en)
AR (1) AR198301A1 (en)
AT (1) AT333285B (en)
AU (1) AU474791B2 (en)
BE (1) BE796036A (en)
BR (1) BR7301392D0 (en)
CA (1) CA992084A (en)
CH (1) CH569010A5 (en)
CS (2) CS179450B2 (en)
CY (1) CY867A (en)
DE (1) DE2310044A1 (en)
DK (1) DK144012C (en)
ES (1) ES411984A1 (en)
FI (1) FI56178C (en)
FR (1) FR2181757B1 (en)
GB (1) GB1387324A (en)
HK (1) HK51476A (en)
HU (1) HU165112B (en)
IE (1) IE37317B1 (en)
IL (1) IL41662A (en)
IN (1) IN138638B (en)
KE (1) KE2650A (en)
MX (1) MX3448E (en)
MY (1) MY7600279A (en)
NL (1) NL7302525A (en)
NO (1) NO137388C (en)
PL (1) PL92977B1 (en)
RO (2) RO76582A (en)
SE (1) SE397978B (en)
YU (1) YU35366B (en)
ZA (1) ZA731182B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062940A1 (en) * 1993-03-11 1994-12-16 Vita Invest Sa Gastrokinetic agent, process for its preparation and pharmaceutical compositions containing said agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062940A1 (en) * 1993-03-11 1994-12-16 Vita Invest Sa Gastrokinetic agent, process for its preparation and pharmaceutical compositions containing said agent

Also Published As

Publication number Publication date
AU474791B2 (en) 1976-08-05
RO71992A (en) 1982-09-09
IN138638B (en) 1976-03-06
IE37317L (en) 1973-08-29
PL92977B1 (en) 1977-04-30
AR198301A1 (en) 1974-06-14
YU35366B (en) 1980-12-31
CS179450B2 (en) 1977-10-31
CS179411B2 (en) 1977-10-31
ATA178473A (en) 1976-03-15
FI56178B (en) 1979-08-31
CY867A (en) 1976-12-17
HK51476A (en) 1976-08-20
JPS5335078B2 (en) 1978-09-25
IL41662A (en) 1977-10-31
MX3448E (en) 1980-12-02
YU49973A (en) 1980-06-30
IE37317B1 (en) 1977-06-22
FR2181757B1 (en) 1976-12-31
CH569010A5 (en) 1975-11-14
GB1387324A (en) 1975-03-12
FR2181757A1 (en) 1973-12-07
DK144012C (en) 1982-04-26
AT333285B (en) 1976-11-10
IL41662A0 (en) 1973-05-31
FI56178C (en) 1979-12-10
RO76582A (en) 1981-04-30
JPS4892385A (en) 1973-11-30
DK144012B (en) 1981-11-16
NO137388C (en) 1978-02-22
NL7302525A (en) 1973-08-31
CA992084A (en) 1976-06-29
BE796036A (en) 1973-06-18
DE2310044A1 (en) 1973-09-13
SE397978B (en) 1977-11-28
NO137388B (en) 1977-11-14
AU5230973A (en) 1974-08-22
BR7301392D0 (en) 1974-08-29
MY7600279A (en) 1976-12-31
KE2650A (en) 1976-07-30
HU165112B (en) 1974-06-28
ZA731182B (en) 1974-11-27

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