GB1387324A - Nitrogen containing isoprenoid compounds - Google Patents

Nitrogen containing isoprenoid compounds

Info

Publication number
GB1387324A
GB1387324A GB934872A GB934872A GB1387324A GB 1387324 A GB1387324 A GB 1387324A GB 934872 A GB934872 A GB 934872A GB 934872 A GB934872 A GB 934872A GB 1387324 A GB1387324 A GB 1387324A
Authority
GB
United Kingdom
Prior art keywords
trimethyldodecatrienyl
benzo
feb
compound
nitrogen containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB934872A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel SpA filed Critical Pierrel SpA
Priority to GB934872A priority Critical patent/GB1387324A/en
Priority to MX004906U priority patent/MX3448E/en
Priority to AU52309/73A priority patent/AU474791B2/en
Priority to IN385/CAL/73A priority patent/IN138638B/en
Priority to ZA731182A priority patent/ZA731182B/en
Priority to FI506/73A priority patent/FI56178C/en
Priority to AR246682A priority patent/AR198301A1/en
Priority to CY867A priority patent/CY867A/en
Priority to FR7306245A priority patent/FR2181757B1/fr
Priority to NL7302525A priority patent/NL7302525A/xx
Priority to ES411984A priority patent/ES411984A1/en
Priority to IE284/73A priority patent/IE37317B1/en
Priority to CS7600002329A priority patent/CS179450B2/en
Priority to CS7300001348A priority patent/CS179411B2/en
Priority to BR731392A priority patent/BR7301392D0/en
Priority to CH281773A priority patent/CH569010A5/xx
Priority to CA164,748A priority patent/CA992084A/en
Priority to HUPI378A priority patent/HU165112B/hu
Priority to SE7302708A priority patent/SE397978B/en
Priority to NO800/73A priority patent/NO137388C/en
Priority to YU499/73A priority patent/YU35366B/en
Priority to BE128167A priority patent/BE796036A/en
Priority to DK103873A priority patent/DK144012C/en
Priority to RO7382295A priority patent/RO76582A/en
Priority to JP2420373A priority patent/JPS5335078B2/ja
Priority to RO7374009A priority patent/RO71992A/en
Priority to AT178473A priority patent/AT333285B/en
Priority to PL1973160969A priority patent/PL92977B1/pl
Priority to IL41662A priority patent/IL41662A/en
Priority to DE19732310044 priority patent/DE2310044A1/en
Priority to US345256A priority patent/US3875163A/en
Priority to US507230A priority patent/US3923986A/en
Publication of GB1387324A publication Critical patent/GB1387324A/en
Priority to KE2650*UA priority patent/KE2650A/en
Priority to HK514/76*UA priority patent/HK51476A/en
Priority to MY1976279A priority patent/MY7600279A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1387324 Derivative of 1-trimethyldodecatrienylpiperazine PIERREL SPA 21 Feb 1973 [29 Feb 1972] 9348/72 Heading C2C The invention comprises the compound of formula including the stereoisomers, and their pharmaceutically acceptable acid addition salts. In examples, their preparation is effected by reacting either (1) the trimethyldodecatrienyl bromide with 1-(benzo-1,3-dioxal-5-yl)methylpiperazine, or (2) 1-(trimethyldodecatrienyl)piperazine (II) with 1-(benzo-1,3-dioxol-5-yl)methyl chloride. Also prepared are the N-formyl and N-p-tosyl derivatives of II. Therapeutic compositions for oral or parenteral administration comprise the compound of the above formula, which has analgesic and antiinflammatory activity, spasmolytic action of the papaverinic type, and anti-gastric secretion and anti-ulcer activity but with absence of anti-cholinergic properties.
GB934872A 1972-02-29 1972-02-29 Nitrogen containing isoprenoid compounds Expired GB1387324A (en)

Priority Applications (35)

Application Number Priority Date Filing Date Title
GB934872A GB1387324A (en) 1972-02-29 1972-02-29 Nitrogen containing isoprenoid compounds
MX004906U MX3448E (en) 1972-02-29 1973-02-15 PROCEDURE TO PREPARE N1-PIPERONIL-N4-3,7,11-TRIMETIL-2,6,10-DODECATRIENILPIPERAZINA
AU52309/73A AU474791B2 (en) 1972-02-29 1973-02-19 Nitrogen containing acyclic isoprenoid compounds
IN385/CAL/73A IN138638B (en) 1972-02-29 1973-02-20
ZA731182A ZA731182B (en) 1972-02-29 1973-02-20 Nitrogen containing acyclic isoprenoid compounds
FI506/73A FI56178C (en) 1972-02-29 1973-02-20 PROCEDURE FOR THE FRAMEWORK OF THE PHARMACEUTICAL SYSTEM
AR246682A AR198301A1 (en) 1972-02-29 1973-02-20 PROCEDURE FOR THE PREPARATION OF N-PIPERONIL-N4-3,7,11-TRIMETHYL-2,6,10-DODECATRIENYLPIPERAZINE
CY867A CY867A (en) 1972-02-29 1973-02-21 Nitrogen containing isoprenoid compounds
FR7306245A FR2181757B1 (en) 1972-02-29 1973-02-22
NL7302525A NL7302525A (en) 1972-02-29 1973-02-23
ES411984A ES411984A1 (en) 1972-02-29 1973-02-23 Nitrogen containing isoprenoid compounds
IE284/73A IE37317B1 (en) 1972-02-29 1973-02-23 Nitrogen containing isoprenoid compounds
CS7600002329A CS179450B2 (en) 1972-02-29 1973-02-24 Method for preparation of new n1-piperonyl-n4-3,7,11-trimethyl-2,6,10-dodecatrienylpiperazine
CS7300001348A CS179411B2 (en) 1972-02-29 1973-02-24 Method for production of new n1-piperonyl-n4-3,7,11-trimethyl-2,6,10-dodecatrienyl-piperazine.
BR731392A BR7301392D0 (en) 1972-02-29 1973-02-26 ACYCLIC ISOPRENOID COMPOUNDS CONTAINING NITROGEN
HUPI378A HU165112B (en) 1972-02-29 1973-02-27
CA164,748A CA992084A (en) 1972-02-29 1973-02-27 Nytrogen containing acyclic isoprenoid compounds
CH281773A CH569010A5 (en) 1972-02-29 1973-02-27
SE7302708A SE397978B (en) 1972-02-29 1973-02-27 PROCEDURE FOR PREPARATION OF NŸ1 -PIPERONYL-NŸ4-3,7,11-TRIMETHYL-2,6,10-DODEKATRIENYLPIPERAZINE
NO800/73A NO137388C (en) 1972-02-29 1973-02-27 ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE N1-PIPERONYL-N4-3,7,11-TRIMETHYL-2,6,10-DODECATRIENYLPIPERAZINE AND ITS GEOMETRIC ISOMERS
YU499/73A YU35366B (en) 1972-02-29 1973-02-27 Process for obtaining n1-piperonyl-n4-3,7,11-trimethyl-2,6,10-dodecatrienyl-piperazine
BE128167A BE796036A (en) 1972-02-29 1973-02-27 NITROGEN ACYCLIC ISOPRENOIDS COMPOUNDS
DK103873A DK144012C (en) 1972-02-29 1973-02-27 METHOD OF ANALOGUE FOR THE PREPARATION OF N1-PIPERONYL-N4-3,7,11-TRIMETHYL-2,6,10-DODECATRIENYLPIPERAZINE OR THERAPEUTIC ACCEPTABLE ACID ADDITION SALTS.
AT178473A AT333285B (en) 1972-02-29 1973-02-28 METHOD OF PREPARING THE NEW N1-PIPERONYL-N4-3,7,11-TRIMETHYL-2,6,10-DODECATRIENYL PIPERAZINE, ITS GEOMETRIC ISOMERS, AND SALTS THEREOF
JP2420373A JPS5335078B2 (en) 1972-02-29 1973-02-28
RO7374009A RO71992A (en) 1972-02-29 1973-02-28 PROCEDURE FOR THE PREPARATION OF NITROGEN-ACID CALCIUM COMPOUNDS
RO7382295A RO76582A (en) 1972-02-29 1973-02-28 PROCESS FOR THE PREPARATION OF PIPERAZINE DERIVATIVES
PL1973160969A PL92977B1 (en) 1972-02-29 1973-02-28
IL41662A IL41662A (en) 1972-02-29 1973-02-28 Cis and trans n1-piperonyl-n4-farnesyl-piperazine its preparation and pharmaceutical compositions containing it
DE19732310044 DE2310044A1 (en) 1972-02-29 1973-02-28 NITROGEN CONTAINING ACYCLIC ISOPRENOID COMPOUNDS
US345256A US3875163A (en) 1972-02-29 1973-03-27 Nitrogen containing acyclic isoprenoid compounds
US507230A US3923986A (en) 1972-02-29 1974-09-18 Nitrogen containing acyclic isoprenoid compounds in pharmaceutical compositions
KE2650*UA KE2650A (en) 1972-02-29 1976-07-19 Nitrogen containing isoprenoid compounds
HK514/76*UA HK51476A (en) 1972-02-29 1976-08-12 Nitrogen containing isoprenoid compounds
MY1976279A MY7600279A (en) 1972-02-29 1976-12-31 Nitrogen containing isoprenoid compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB934872A GB1387324A (en) 1972-02-29 1972-02-29 Nitrogen containing isoprenoid compounds

Publications (1)

Publication Number Publication Date
GB1387324A true GB1387324A (en) 1975-03-12

Family

ID=9870216

Family Applications (1)

Application Number Title Priority Date Filing Date
GB934872A Expired GB1387324A (en) 1972-02-29 1972-02-29 Nitrogen containing isoprenoid compounds

Country Status (31)

Country Link
JP (1) JPS5335078B2 (en)
AR (1) AR198301A1 (en)
AT (1) AT333285B (en)
AU (1) AU474791B2 (en)
BE (1) BE796036A (en)
BR (1) BR7301392D0 (en)
CA (1) CA992084A (en)
CH (1) CH569010A5 (en)
CS (2) CS179450B2 (en)
CY (1) CY867A (en)
DE (1) DE2310044A1 (en)
DK (1) DK144012C (en)
ES (1) ES411984A1 (en)
FI (1) FI56178C (en)
FR (1) FR2181757B1 (en)
GB (1) GB1387324A (en)
HK (1) HK51476A (en)
HU (1) HU165112B (en)
IE (1) IE37317B1 (en)
IL (1) IL41662A (en)
IN (1) IN138638B (en)
KE (1) KE2650A (en)
MX (1) MX3448E (en)
MY (1) MY7600279A (en)
NL (1) NL7302525A (en)
NO (1) NO137388C (en)
PL (1) PL92977B1 (en)
RO (2) RO76582A (en)
SE (1) SE397978B (en)
YU (1) YU35366B (en)
ZA (1) ZA731182B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062940B1 (en) * 1993-03-11 1995-06-16 Vita Invest Sa GASTROCINETIC AGENT, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.

Also Published As

Publication number Publication date
IN138638B (en) 1976-03-06
DE2310044A1 (en) 1973-09-13
RO71992A (en) 1982-09-09
DK144012B (en) 1981-11-16
DK144012C (en) 1982-04-26
CH569010A5 (en) 1975-11-14
AU474791B2 (en) 1976-08-05
JPS5335078B2 (en) 1978-09-25
YU35366B (en) 1980-12-31
ATA178473A (en) 1976-03-15
IE37317B1 (en) 1977-06-22
JPS4892385A (en) 1973-11-30
CS179450B2 (en) 1977-10-31
NO137388B (en) 1977-11-14
CY867A (en) 1976-12-17
AT333285B (en) 1976-11-10
BR7301392D0 (en) 1974-08-29
FR2181757A1 (en) 1973-12-07
RO76582A (en) 1981-04-30
MY7600279A (en) 1976-12-31
NO137388C (en) 1978-02-22
ES411984A1 (en) 1976-06-16
IE37317L (en) 1973-08-29
FR2181757B1 (en) 1976-12-31
FI56178C (en) 1979-12-10
YU49973A (en) 1980-06-30
SE397978B (en) 1977-11-28
HU165112B (en) 1974-06-28
CA992084A (en) 1976-06-29
CS179411B2 (en) 1977-10-31
AR198301A1 (en) 1974-06-14
IL41662A0 (en) 1973-05-31
KE2650A (en) 1976-07-30
BE796036A (en) 1973-06-18
ZA731182B (en) 1974-11-27
MX3448E (en) 1980-12-02
HK51476A (en) 1976-08-20
FI56178B (en) 1979-08-31
PL92977B1 (en) 1977-04-30
NL7302525A (en) 1973-08-31
AU5230973A (en) 1974-08-22
IL41662A (en) 1977-10-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee