IE35727B1 - Novel benzodiazepines the preparation thereof and compositions containing the same - Google Patents
Novel benzodiazepines the preparation thereof and compositions containing the sameInfo
- Publication number
- IE35727B1 IE35727B1 IE753/70A IE75370A IE35727B1 IE 35727 B1 IE35727 B1 IE 35727B1 IE 753/70 A IE753/70 A IE 753/70A IE 75370 A IE75370 A IE 75370A IE 35727 B1 IE35727 B1 IE 35727B1
- Authority
- IE
- Ireland
- Prior art keywords
- group
- general formula
- benzodiazepin
- tetrahydro
- reaction
- Prior art date
Links
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 150000001557 benzodiazepines Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 7
- 238000006243 chemical reaction Methods 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 238000007363 ring formation reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- -1 heteroaryl halide Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19691929656 DE1929656A1 (de) | 1969-06-11 | 1969-06-11 | Neue Tetrahydro-benzodiazepinone |
| DE19702006600 DE2006600A1 (en) | 1970-02-13 | 1970-02-13 | Tetrahydro-1,5-benzodiazepine-4-ones |
| DE19702019627 DE2019627A1 (de) | 1969-06-11 | 1970-04-23 | Neue Tetrahydrobenzodiazepinone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35727L IE35727L (en) | 1970-12-11 |
| IE35727B1 true IE35727B1 (en) | 1976-05-12 |
Family
ID=27181978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE753/70A IE35727B1 (en) | 1969-06-11 | 1970-06-10 | Novel benzodiazepines the preparation thereof and compositions containing the same |
Country Status (16)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110256365B (zh) * | 2019-06-24 | 2022-06-07 | 陕西师范大学 | 二氯二茂钛催化制备苯二氮卓衍生物的方法 |
| CN110183397B (zh) * | 2019-06-24 | 2022-08-23 | 陕西师范大学 | 二氯二茂锆催化制备1,5-苯并噻嗪类化合物的方法 |
-
1970
- 1970-04-10 BG BG014913A patent/BG17602A3/xx unknown
- 1970-06-05 RO RO69784A patent/RO58641A/ro unknown
- 1970-06-05 SU SU701666624A patent/SU423299A3/ru active
- 1970-06-05 CA CA084,760A patent/CA967154A/en not_active Expired
- 1970-06-05 RO RO69783A patent/RO58640A/ro unknown
- 1970-06-05 RO RO69785A patent/RO58887A/ro unknown
- 1970-06-05 RO RO63562A patent/RO58405A/ro unknown
- 1970-06-09 IL IL34689A patent/IL34689A/en unknown
- 1970-06-09 CH CH863170A patent/CH549582A/xx not_active IP Right Cessation
- 1970-06-09 ES ES380557A patent/ES380557A1/es not_active Expired
- 1970-06-10 IE IE753/70A patent/IE35727B1/xx unknown
- 1970-06-10 AT AT522570A patent/AT303737B/de not_active IP Right Cessation
- 1970-06-10 GB GB2819770A patent/GB1317475A/en not_active Expired
- 1970-06-10 NO NO02256/70A patent/NO129524B/no unknown
- 1970-06-10 NL NL7008404A patent/NL7008404A/xx unknown
- 1970-06-10 AT AT00409/72A patent/AT303746B/de not_active IP Right Cessation
- 1970-06-10 BG BG017289A patent/BG17974A3/xx unknown
- 1970-06-10 BG BG017287A patent/BG17973A3/xx unknown
- 1970-06-11 FR FR7021448A patent/FR2052950B1/fr not_active Expired
- 1970-06-11 SE SE7008152A patent/SE381873B/xx unknown
- 1970-06-11 BE BE751834D patent/BE751834A/xx unknown
-
1971
- 1971-01-11 ES ES71387137A patent/ES387137A1/es not_active Expired
- 1971-01-11 ES ES387136A patent/ES387136A1/es not_active Expired
- 1971-01-11 ES ES387138A patent/ES387138A1/es not_active Expired
- 1971-04-07 BG BG017288A patent/BG17603A3/xx unknown
- 1971-10-01 JP JP46077046A patent/JPS49192B1/ja active Pending
- 1971-10-01 JP JP46077048A patent/JPS5031158B1/ja active Pending
- 1971-10-01 JP JP46077047A patent/JPS5013273B1/ja active Pending
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