IE35404B1 - New penicillins their preparation and their use - Google Patents
New penicillins their preparation and their useInfo
- Publication number
- IE35404B1 IE35404B1 IE644/71A IE64471A IE35404B1 IE 35404 B1 IE35404 B1 IE 35404B1 IE 644/71 A IE644/71 A IE 644/71A IE 64471 A IE64471 A IE 64471A IE 35404 B1 IE35404 B1 IE 35404B1
- Authority
- IE
- Ireland
- Prior art keywords
- group
- formulμ
- carbon atoms
- lower alkyl
- alkyl
- Prior art date
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 6
- 150000002960 penicillins Chemical class 0.000 title abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 13
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- -1 Ureido penicillins Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004104 aryloxy group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 2
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 2
- 229920002554 vinyl polymer Polymers 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003609 aryl vinyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000004385 trihaloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/58—Y being a hetero atom
- C07C275/60—Y being an oxygen atom, e.g. allophanic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2025415A DE2025415C3 (de) | 1970-05-25 | 1970-05-25 | Verfahren zur Herstellung von cyclischen Acylureido-Penicillinen |
| DE19712104579 DE2104579C3 (de) | 1971-02-01 | 1971-02-01 | Cyclische Acylureidopenicilline und sie enthaltende Arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35404L IE35404L (en) | 1971-11-25 |
| IE35404B1 true IE35404B1 (en) | 1976-02-04 |
Family
ID=25759180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE644/71A IE35404B1 (en) | 1970-05-25 | 1971-05-21 | New penicillins their preparation and their use |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS55390B1 (fi) |
| AT (1) | AT306924B (fi) |
| BE (1) | BE767648A (fi) |
| BG (1) | BG23753A3 (fi) |
| CA (1) | CA932722A (fi) |
| CH (1) | CH571524A5 (fi) |
| CS (1) | CS185564B2 (fi) |
| CY (1) | CY830A (fi) |
| DD (1) | DD91496B3 (fi) |
| DK (1) | DK134438C (fi) |
| EG (1) | EG10490A (fi) |
| ES (4) | ES391533A1 (fi) |
| FI (1) | FI54485C (fi) |
| FR (1) | FR2100682B1 (fi) |
| GB (1) | GB1301962A (fi) |
| IE (1) | IE35404B1 (fi) |
| IL (1) | IL36904A (fi) |
| KE (1) | KE2591A (fi) |
| LU (1) | LU63204A1 (fi) |
| NL (1) | NL172659C (fi) |
| NO (1) | NO141759C (fi) |
| PH (1) | PH12110A (fi) |
| RO (1) | RO59290A (fi) |
| SE (1) | SE395895B (fi) |
| SU (1) | SU420181A3 (fi) |
| YU (1) | YU35889B (fi) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2260118C2 (de) * | 1972-12-08 | 1982-06-03 | Bayer Ag, 5090 Leverkusen | Penicilline sowie ihre Verwendung als Arzneimittel |
| DE2354219A1 (de) * | 1973-10-30 | 1975-05-07 | Bayer Ag | Beta-lactam-antibiotica, ein verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4039673A (en) | 1973-10-30 | 1977-08-02 | Bayer Aktiengesellschaft | Penicillins and cephalosporins and their production |
| GB1486349A (en) * | 1974-11-28 | 1977-09-21 | Bayer Ag | Beta-lactam antibiotics process for their preparation and their use as medicaments |
| GB1584400A (en) * | 1976-12-24 | 1981-02-11 | Bayer Ag | (2-oxo-imidazoliden-1-yl(carbonylamino)-acetamido-cephalosporins and penicillins |
| KR860000300B1 (ko) * | 1983-12-19 | 1986-03-31 | 보령제약 주식회사 | 아실우레이도 페니실린 유도체의 제조방법 |
-
1971
- 1971-04-23 CH CH599171A patent/CH571524A5/xx not_active IP Right Cessation
- 1971-05-18 BG BG7100017581A patent/BG23753A3/xx unknown
- 1971-05-19 EG EG212/71A patent/EG10490A/xx active
- 1971-05-19 CS CS7100003647A patent/CS185564B2/cs unknown
- 1971-05-20 SU SU1660129A patent/SU420181A3/ru active
- 1971-05-21 FI FI1402/71A patent/FI54485C/fi active
- 1971-05-21 IE IE644/71A patent/IE35404B1/xx unknown
- 1971-05-21 LU LU63204D patent/LU63204A1/xx unknown
- 1971-05-24 PH PH12494A patent/PH12110A/en unknown
- 1971-05-24 YU YU1296/71A patent/YU35889B/xx unknown
- 1971-05-24 DD DD71155308A patent/DD91496B3/de unknown
- 1971-05-24 DK DK251171A patent/DK134438C/da not_active IP Right Cessation
- 1971-05-24 SE SE7106668A patent/SE395895B/xx unknown
- 1971-05-24 NO NO1946/71A patent/NO141759C/no unknown
- 1971-05-24 IL IL7136904A patent/IL36904A/xx unknown
- 1971-05-25 JP JP3524571A patent/JPS55390B1/ja active Pending
- 1971-05-25 RO RO67015A patent/RO59290A/ro unknown
- 1971-05-25 CY CY830A patent/CY830A/xx unknown
- 1971-05-25 ES ES391533A patent/ES391533A1/es not_active Expired
- 1971-05-25 BE BE767648A patent/BE767648A/xx not_active IP Right Cessation
- 1971-05-25 AT AT450571A patent/AT306924B/de not_active IP Right Cessation
- 1971-05-25 FR FR7118933A patent/FR2100682B1/fr not_active Expired
- 1971-05-25 CA CA113785A patent/CA932722A/en not_active Expired
- 1971-05-25 GB GB1688171A patent/GB1301962A/en not_active Expired
- 1971-05-25 NL NLAANVRAGE7107176,A patent/NL172659C/xx not_active IP Right Cessation
-
1973
- 1973-02-16 ES ES411675A patent/ES411675A1/es not_active Expired
- 1973-02-16 ES ES411676A patent/ES411676A1/es not_active Expired
- 1973-02-16 ES ES411674A patent/ES411674A1/es not_active Expired
-
1975
- 1975-12-22 KE KE2591*UA patent/KE2591A/xx unknown
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