IE35234B1 - 2-(substituted phenyl) propionic acids - Google Patents
2-(substituted phenyl) propionic acidsInfo
- Publication number
- IE35234B1 IE35234B1 IE302/71A IE30271A IE35234B1 IE 35234 B1 IE35234 B1 IE 35234B1 IE 302/71 A IE302/71 A IE 302/71A IE 30271 A IE30271 A IE 30271A IE 35234 B1 IE35234 B1 IE 35234B1
- Authority
- IE
- Ireland
- Prior art keywords
- acids
- fluorophenoxy
- phenyl
- compounds
- acetophenone
- Prior art date
Links
- -1 2-(substituted phenyl) propionic acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 4
- 150000007513 acids Chemical class 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- YPGCWEMNNLXISK-UHFFFAOYSA-N hydratropic acid Chemical class OC(=O)C(C)C1=CC=CC=C1 YPGCWEMNNLXISK-UHFFFAOYSA-N 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- QDKWLJJOYIFEBS-UHFFFAOYSA-N 1-fluoro-4-$l^{1}-oxidanylbenzene Chemical group [O]C1=CC=C(F)C=C1 QDKWLJJOYIFEBS-UHFFFAOYSA-N 0.000 abstract 1
- XKFRVONIRHUCLL-UHFFFAOYSA-N 2-[4-(2,4-difluorophenoxy)phenyl]propanoyl chloride Chemical compound FC1=C(OC2=CC=C(C=C2)C(C(=O)Cl)C)C=CC(=C1)F XKFRVONIRHUCLL-UHFFFAOYSA-N 0.000 abstract 1
- JEWMYTWSCLIAMM-UHFFFAOYSA-N 2-[4-(4-fluorophenoxy)phenyl]-2-methylpropanedioic acid Chemical compound C1=CC(C(C(O)=O)(C(O)=O)C)=CC=C1OC1=CC=C(F)C=C1 JEWMYTWSCLIAMM-UHFFFAOYSA-N 0.000 abstract 1
- VMMSFFIABDLZIP-UHFFFAOYSA-N 2-[4-(4-fluorophenoxy)phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1OC1=CC=C(F)C=C1 VMMSFFIABDLZIP-UHFFFAOYSA-N 0.000 abstract 1
- 238000006887 Ullmann reaction Methods 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 238000006114 decarboxylation reaction Methods 0.000 abstract 1
- ZEVNFCCTUHBNRS-UHFFFAOYSA-N diethyl 2-[3-chloro-4-(4-fluorophenoxy)phenyl]-2-methylpropanedioate Chemical compound ClC=1C=C(C=CC1OC1=CC=C(C=C1)F)C(C(=O)OCC)(C(=O)OCC)C ZEVNFCCTUHBNRS-UHFFFAOYSA-N 0.000 abstract 1
- HIDIPLYXGTXGMP-UHFFFAOYSA-N diethyl 2-[4-(4-chlorophenoxy)phenyl]-2-methylpropanedioate Chemical compound ClC1=CC=C(OC2=CC=C(C=C2)C(C(=O)OCC)(C(=O)OCC)C)C=C1 HIDIPLYXGTXGMP-UHFFFAOYSA-N 0.000 abstract 1
- DEHYUWGCDHLRJU-UHFFFAOYSA-N diethyl 2-[4-(4-fluorophenoxy)phenyl]-2-methylpropanedioate Chemical compound FC1=CC=C(OC2=CC=C(C=C2)C(C(=O)OCC)(C(=O)OCC)C)C=C1 DEHYUWGCDHLRJU-UHFFFAOYSA-N 0.000 abstract 1
- GPFMNAJSYBRVPH-UHFFFAOYSA-N ethyl 2-[3-chloro-4-(4-fluorophenoxy)phenyl]acetate Chemical compound ClC1=CC(CC(=O)OCC)=CC=C1OC1=CC=C(F)C=C1 GPFMNAJSYBRVPH-UHFFFAOYSA-N 0.000 abstract 1
- MJXXROBCOJLPMM-UHFFFAOYSA-N ethyl 2-[4-(4-chlorophenoxy)phenyl]acetate Chemical compound C1=CC(CC(=O)OCC)=CC=C1OC1=CC=C(Cl)C=C1 MJXXROBCOJLPMM-UHFFFAOYSA-N 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
- 235000019260 propionic acid Nutrition 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1257070 | 1970-03-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35234L IE35234L (en) | 1971-09-16 |
| IE35234B1 true IE35234B1 (en) | 1975-12-24 |
Family
ID=10007088
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE302/71A IE35234B1 (en) | 1970-03-16 | 1971-03-10 | 2-(substituted phenyl) propionic acids |
| IE301/71A IE35109B1 (en) | 1970-03-16 | 1971-03-10 | 2-(substituted phenyl) propionic acids |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE301/71A IE35109B1 (en) | 1970-03-16 | 1971-03-10 | 2-(substituted phenyl) propionic acids |
Country Status (18)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2837525A1 (de) * | 1978-08-28 | 1980-03-20 | Bayer Ag | Verfahren zur herstellung von 4- fluoro-3-phenoxy-toluol |
| SE8400239D0 (sv) * | 1984-01-19 | 1984-01-19 | Pharmacia Ab | Nya arylettiksyraderivat |
| HUT55742A (en) * | 1987-12-28 | 1991-06-28 | Dowelanco | Process for producing (phenoxy-phenoxy)-propionate derivatives and theyr new intermediates |
| ES2163986B1 (es) * | 1999-07-13 | 2003-02-16 | Menarini Lab | Acidos-alfa-arilpropionicos y arilaceticos como inhibidores de la ciclooxigenasa-ii. |
| FR2862964B1 (fr) * | 2003-11-27 | 2006-12-29 | Merck Sante Sas | Derives de la diphenylamine. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE363818B (enrdf_load_stackoverflow) * | 1968-08-15 | 1974-02-04 | Lilly Co Eli |
-
1970
- 1970-03-16 GB GB1257070A patent/GB1307284A/en not_active Expired
-
1971
- 1971-03-04 CA CA106862A patent/CA925878A/en not_active Expired
- 1971-03-04 CA CA106861A patent/CA925520A/en not_active Expired
- 1971-03-05 NL NL7103404A patent/NL7103404A/xx not_active Application Discontinuation
- 1971-03-10 IE IE302/71A patent/IE35234B1/xx unknown
- 1971-03-10 IE IE301/71A patent/IE35109B1/xx unknown
- 1971-03-11 IL IL36395A patent/IL36395A/xx unknown
- 1971-03-11 IL IL36394A patent/IL36394A/en unknown
- 1971-03-12 ZA ZA711643A patent/ZA711643B/xx unknown
- 1971-03-12 ZA ZA711644A patent/ZA711644B/xx unknown
- 1971-03-15 DE DE19712112323 patent/DE2112323A1/de active Pending
- 1971-03-15 BE BE764258A patent/BE764258A/xx unknown
- 1971-03-15 PL PL1971146901A patent/PL70292B1/pl unknown
- 1971-03-15 NO NO71981A patent/NO131507C/no unknown
- 1971-03-15 NL NL7103403A patent/NL7103403A/xx unknown
- 1971-03-15 CS CS3910*A patent/CS170543B2/cs unknown
- 1971-03-15 PL PL1971182995A patent/PL94402B1/pl unknown
- 1971-03-15 FR FR7108943A patent/FR2085713B1/fr not_active Expired
- 1971-03-15 NO NO71980A patent/NO132989C/no unknown
- 1971-03-15 CS CS6523*A patent/CS169814B2/cs unknown
- 1971-03-15 FR FR7108942A patent/FR2085712B1/fr not_active Expired
- 1971-03-15 BE BE764257A patent/BE764257A/xx unknown
- 1971-03-15 PL PL1971182996A patent/PL94403B1/pl unknown
- 1971-03-15 DE DE19712112322 patent/DE2112322A1/de active Pending
- 1971-03-15 CS CS1864A patent/CS169813B2/cs unknown
- 1971-03-15 ES ES389252A patent/ES389252A1/es not_active Expired
- 1971-03-15 ES ES389253A patent/ES389253A1/es not_active Expired
- 1971-03-15 DK DK120971AA patent/DK139673B/da unknown
- 1971-03-15 SE SE03327/71A patent/SE366732B/xx unknown
- 1971-03-15 SE SE03328/71A patent/SE366733B/xx unknown
- 1971-03-15 CS CS1863A patent/CS170542B2/cs unknown
- 1971-03-15 PL PL1971146906A patent/PL72430B1/pl unknown
- 1971-03-16 CH CH378871A patent/CH530363A/fr not_active IP Right Cessation
- 1971-03-16 RO RO66285A patent/RO61058A/ro unknown
- 1971-03-16 AT AT1065372A patent/AT318576B/de not_active IP Right Cessation
- 1971-03-16 AT AT227071A patent/AT318575B/de active
- 1971-03-16 RO RO68712A patent/RO62254A/ro unknown
- 1971-03-16 AT AT226971A patent/AT318574B/de active
- 1971-03-16 RO RO66280A patent/RO61093A/ro unknown
- 1971-03-16 RO RO68711A patent/RO61065A/ro unknown
- 1971-03-16 CH CH378771A patent/CH532010A/fr not_active IP Right Cessation
- 1971-03-16 AT AT1065472A patent/AT318577B/de not_active IP Right Cessation
-
1972
- 1972-01-12 ES ES398803A patent/ES398803A1/es not_active Expired
- 1972-01-12 ES ES398802A patent/ES398802A1/es not_active Expired
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