IE36205B1 - Substituted biphenyls - Google Patents

Substituted biphenyls

Info

Publication number
IE36205B1
IE36205B1 IE284/72A IE28472A IE36205B1 IE 36205 B1 IE36205 B1 IE 36205B1 IE 284/72 A IE284/72 A IE 284/72A IE 28472 A IE28472 A IE 28472A IE 36205 B1 IE36205 B1 IE 36205B1
Authority
IE
Ireland
Prior art keywords
cooh
corresponding compound
group
conhoh
reaction
Prior art date
Application number
IE284/72A
Other versions
IE36205L (en
Original Assignee
Boots Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co Ltd filed Critical Boots Co Ltd
Publication of IE36205L publication Critical patent/IE36205L/en
Publication of IE36205B1 publication Critical patent/IE36205B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings

Abstract

1382996 Biphenyl derivatives BOOTS CO Ltd 7 March 1972 [26 March 1971] 7936/71 Heading C2C Novel biphenyl derivatives of the general formula wherein each of R 1 , R 2 and R 3 is a chlorine, bromine or fluorine atom and Y is COOH, CONH 2 , CH 2 OH or CONHOH, and pharmaceutically acceptable esters, inorganic base addition salts and organic base addition salts of those derivatives wherein Y is COOH and inorganic base addition salts of those derivatives wherein Y is CONHOH, are prepared, e.g. (a) when Y is COOH, by hydrolysis of the corresponding compound in which Z is CONH 2 , an ester-forming group or a 4,4 - dialkyl - 2- oxazolinyl-(2) group; (b) when Y is COOH, by decarboxylation of the corresponding compound in which the -CH(CH 3 )Y group is replaced by a -C(CH 3 )(COOH) 2 group; (c) when Y is COOH, by oxidation of the corresponding compound in which Y is CHO; (d) when Y is esterified COOH, by esterification of the corresponding compound in which Y is COOH; (e) when Y is COHN 2 , by reaction of the corresponding compound in which Y is CO-halogen with ammonia; (f) when Y is CH 2 OH, by reduction of the corresponding compound in which Y is esterified COOH; (g) when Y is CONHOH, by reaction of the corresponding compound in which Y is esterified COOH with hydroxylamine; and (h) when Y is salified COOH, by reaction of the corresponding compound in which Y is COOH with a base. Pharmaceutical compositions having antiinflammatory activity comprise, as active ingredient, a biphenyl drivative of the above general formula or pharmaceutically acceptable ester or salt thereof as defined above, in association with a pharmaceutical excipient, and may be administered orally, rectally, topically or parenterally. [GB1382996A]
IE284/72A 1971-03-26 1972-03-07 Substituted biphenyls IE36205B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB793671A GB1382996A (en) 1971-03-26 1971-03-26 Substituted biphenyls

Publications (2)

Publication Number Publication Date
IE36205L IE36205L (en) 1972-09-26
IE36205B1 true IE36205B1 (en) 1976-09-15

Family

ID=9842634

Family Applications (1)

Application Number Title Priority Date Filing Date
IE284/72A IE36205B1 (en) 1971-03-26 1972-03-07 Substituted biphenyls

Country Status (19)

Country Link
AR (2) AR195788A1 (en)
AT (2) AT319920B (en)
BE (1) BE781054A (en)
BR (1) BR7201721D0 (en)
CA (1) CA992090A (en)
CH (3) CH552552A (en)
CS (2) CS163799B2 (en)
DE (1) DE2214561A1 (en)
ES (1) ES401176A1 (en)
FR (1) FR2130492B1 (en)
GB (1) GB1382996A (en)
HU (1) HU164381B (en)
IE (1) IE36205B1 (en)
IL (1) IL38957A (en)
NL (1) NL7203920A (en)
NO (1) NO137546C (en)
RO (2) RO62846A (en)
SE (1) SE398112B (en)
ZA (1) ZA721706B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437783A (en) * 1972-09-22 1976-06-03 Boots Co Ltd 2-substituted biphenylyl acetic acids and derivatives thereof
ATA785173A (en) * 1972-08-17 1975-01-15 Thomae Gmbh Dr K PROCESS FOR PREPARING NEW 4- (4-BIPHENYLYL) -4-HYDROXY-BUTTERIC ACID AMIDES
JPS582934B2 (en) * 1974-07-29 1983-01-19 ニツシンセイフン カブシキガイシヤ Process for producing 2-(substituted aryl)-propionic acid
DE3773882D1 (en) * 1987-01-21 1991-11-21 Sumitomo Chemical Co METHOD FOR PRODUCING OPTICALLY ACTIVE ARYL ACETIC DERIVATIVES.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7047A (en) * 1904-07-11

Also Published As

Publication number Publication date
CS163800B2 (en) 1975-11-07
CS163799B2 (en) 1975-11-07
GB1382996A (en) 1975-02-05
IL38957A (en) 1975-08-31
FR2130492B1 (en) 1975-10-31
DE2214561A1 (en) 1972-10-05
BE781054A (en) 1972-09-22
AT319920B (en) 1975-01-10
NO137546B (en) 1977-12-05
NL7203920A (en) 1972-09-28
AT321288B (en) 1975-03-25
RO62846A (en) 1977-11-15
SE398112B (en) 1977-12-05
AR195813A1 (en) 1973-11-09
CH552552A (en) 1974-08-15
AR195788A1 (en) 1973-11-09
RO66640A (en) 1981-06-30
FR2130492A1 (en) 1972-11-03
CH563331A5 (en) 1975-06-30
BR7201721D0 (en) 1973-11-01
IL38957A0 (en) 1972-05-30
NO137546C (en) 1978-03-15
CH562190A5 (en) 1975-05-30
ZA721706B (en) 1972-12-27
ES401176A1 (en) 1975-02-01
IE36205L (en) 1972-09-26
HU164381B (en) 1974-02-28
CA992090A (en) 1976-06-29

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