GB1433977A - Acyl derivatives - Google Patents
Acyl derivativesInfo
- Publication number
- GB1433977A GB1433977A GB5044774A GB5044774A GB1433977A GB 1433977 A GB1433977 A GB 1433977A GB 5044774 A GB5044774 A GB 5044774A GB 5044774 A GB5044774 A GB 5044774A GB 1433977 A GB1433977 A GB 1433977A
- Authority
- GB
- United Kingdom
- Prior art keywords
- glycyl
- propanediol
- nov
- tert
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000002252 acyl group Chemical group 0.000 title 1
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 abstract 1
- 229940035437 1,3-propanediol Drugs 0.000 abstract 1
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 abstract 1
- VRPJIFMKZZEXLR-UHFFFAOYSA-N 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid Chemical compound CC(C)(C)OC(=O)NCC(O)=O VRPJIFMKZZEXLR-UHFFFAOYSA-N 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- PBWZKZYHONABLN-UHFFFAOYSA-N difluoroacetic acid Chemical compound OC(=O)C(F)F PBWZKZYHONABLN-UHFFFAOYSA-N 0.000 abstract 1
- -1 glycyl ester Chemical class 0.000 abstract 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001174 sulfone group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1433977 Sulphones F HOFFMANN-LA ROCHE & CO AG 21 Nov 1974 [22 Nov 1973] 50447/74 Heading C2C Novel compounds (I) (including salts thereof) where R is H or a glycyl group, are made by reacting (II) with difluoroacetic acid or a functional derivative thereof and, if desired, esterifying (I) obtained (R is H) to give the glycyl ester. D - Threo - 1 - [(p - methylsulphonyl)phenyl]- 2 - (2,2 - difluoroacetamido) - 1,3 - propanediol 3 - (N - tert - butyolxycarbonyl) - glycyl ester is obtained by reacting the 1,3-propanediol with N-tert-butyloxycarbonyl-glycine. Pharmaceutical preparations active against gram-positive and -negative micro-organisms contain (I) as active ingredient. Administration is orally, parenterally or topically.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1646873A CH589617A5 (en) | 1973-11-22 | 1973-11-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1433977A true GB1433977A (en) | 1976-04-28 |
Family
ID=4417636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5044774A Expired GB1433977A (en) | 1973-11-22 | 1974-11-21 | Acyl derivatives |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS5083347A (en) |
AT (1) | AT338764B (en) |
BE (1) | BE822446A (en) |
CH (1) | CH589617A5 (en) |
DE (1) | DE2454805A1 (en) |
DK (1) | DK606074A (en) |
FR (1) | FR2252092B1 (en) |
GB (1) | GB1433977A (en) |
HU (1) | HU170835B (en) |
IL (1) | IL45776A (en) |
NL (1) | NL7413346A (en) |
SE (1) | SE7414606L (en) |
ZA (1) | ZA746222B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4945181A (en) * | 1985-12-05 | 1990-07-31 | Boehringer Mannheim Gmbh | Method for resolution of racemic thiamphenicol precursors and intermediates therefor |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1240676B (en) * | 1990-04-24 | 1993-12-17 | Agrimont Spa | COMPOSITIONS WITH HERBICIDE ACTIVITY |
-
1973
- 1973-11-22 CH CH1646873A patent/CH589617A5/xx not_active IP Right Cessation
-
1974
- 1974-09-30 ZA ZA00746222A patent/ZA746222B/en unknown
- 1974-10-03 IL IL45776A patent/IL45776A/en unknown
- 1974-10-10 NL NL7413346A patent/NL7413346A/en not_active Application Discontinuation
- 1974-11-19 DE DE19742454805 patent/DE2454805A1/en active Pending
- 1974-11-20 FR FR7438126A patent/FR2252092B1/fr not_active Expired
- 1974-11-20 HU HU74HO00001741A patent/HU170835B/en unknown
- 1974-11-20 JP JP49133488A patent/JPS5083347A/ja active Pending
- 1974-11-20 SE SE7414606A patent/SE7414606L/xx unknown
- 1974-11-21 DK DK606074A patent/DK606074A/da unknown
- 1974-11-21 BE BE150720A patent/BE822446A/en unknown
- 1974-11-21 GB GB5044774A patent/GB1433977A/en not_active Expired
- 1974-11-21 AT AT933274A patent/AT338764B/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4945181A (en) * | 1985-12-05 | 1990-07-31 | Boehringer Mannheim Gmbh | Method for resolution of racemic thiamphenicol precursors and intermediates therefor |
Also Published As
Publication number | Publication date |
---|---|
ZA746222B (en) | 1975-11-26 |
BE822446A (en) | 1975-05-21 |
CH589617A5 (en) | 1977-07-15 |
IL45776A (en) | 1977-12-30 |
AU7408074A (en) | 1976-04-15 |
SE7414606L (en) | 1975-05-23 |
IL45776A0 (en) | 1974-12-31 |
ATA933274A (en) | 1977-01-15 |
AT338764B (en) | 1977-09-12 |
JPS5083347A (en) | 1975-07-05 |
DE2454805A1 (en) | 1975-05-28 |
NL7413346A (en) | 1975-05-26 |
FR2252092B1 (en) | 1978-07-28 |
DK606074A (en) | 1975-07-21 |
FR2252092A1 (en) | 1975-06-20 |
HU170835B (en) | 1977-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |