GB1492175A - Indane derivatives - Google Patents

Indane derivatives

Info

Publication number
GB1492175A
GB1492175A GB5726/74A GB572674A GB1492175A GB 1492175 A GB1492175 A GB 1492175A GB 5726/74 A GB5726/74 A GB 5726/74A GB 572674 A GB572674 A GB 572674A GB 1492175 A GB1492175 A GB 1492175A
Authority
GB
United Kingdom
Prior art keywords
acids
indan
prepared
formula
indaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5726/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hexachimie SA
Original Assignee
Hexachimie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hexachimie SA filed Critical Hexachimie SA
Priority to GB5726/74A priority Critical patent/GB1492175A/en
Priority to AR257486A priority patent/AR206619A1/en
Priority to AR257487A priority patent/AR206620A1/en
Priority to FR7501002A priority patent/FR2260334A1/en
Priority to BE2054092A priority patent/BE824522A/en
Priority to NO750175A priority patent/NO750175L/no
Priority to NO750176A priority patent/NO146136C/en
Priority to AT75775A priority patent/AT335445B/en
Priority to AT75675A priority patent/AT337678B/en
Priority to ZA00750707A priority patent/ZA75707B/en
Priority to DE19752504689 priority patent/DE2504689A1/en
Priority to ES434478A priority patent/ES434478A1/en
Priority to ES434479A priority patent/ES434479A1/en
Priority to AU77936/75A priority patent/AU493675B2/en
Priority to CA219,396A priority patent/CA1063618A/en
Priority to DK42475*#A priority patent/DK42475A/da
Priority to CH141775A priority patent/CH605567A5/xx
Priority to HUHE000676 priority patent/HU170419B/hu
Priority to DD189368A priority patent/DD123319A5/xx
Priority to DK42575*#A priority patent/DK42575A/da
Priority to HUHE000677 priority patent/HU170420B/hu
Priority to CH141875A priority patent/CH603533A5/xx
Priority to SE7501339A priority patent/SE418177B/en
Priority to SU752108439A priority patent/SU913936A3/en
Priority to DD184040A priority patent/DD118271A5/xx
Priority to DD184036A priority patent/DD117209A5/xx
Priority to SE7501338A priority patent/SE418395B/en
Priority to NL7501518A priority patent/NL7501518A/en
Priority to JP50016776A priority patent/JPS51125367A/en
Priority to JP50016777A priority patent/JPS51125368A/en
Priority to NL7501519A priority patent/NL7501519A/en
Priority to SU762303159A priority patent/SU895280A3/en
Priority to AT367176A priority patent/AT343644B/en
Priority to US05/690,390 priority patent/US4088787A/en
Priority to US05/690,391 priority patent/US4069326A/en
Priority to AR263699A priority patent/AR211541A1/en
Priority to AR263744A priority patent/AR206862A1/en
Priority to AT495576A priority patent/AT343106B/en
Priority to AT495676A priority patent/AT343646B/en
Priority to ES452657A priority patent/ES452657A1/en
Priority to US05/788,033 priority patent/US4182896A/en
Publication of GB1492175A publication Critical patent/GB1492175A/en
Priority to SE7713839A priority patent/SE7713839L/en
Priority to NO800268A priority patent/NO800268L/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/194—Radicals derived from thio- or thiono carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/34—Monohydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Abstract

1492175 Indan-5-acetic acid and indan-5- ethanol derivatives HEXACHIMIE 6 Feb 1975 [7 Feb 1974 23 Aug 1974 16 Dec 1974] 5726/74 37220/74 and 54292/74 Heading C2C The invention comprises compounds of formula wherein X is H or halogen; R 1 and R 2 are each H, C 1-5 alkyl or C 3-7 cycloalkyl; provided that at least one of them is other than H; R 3 is H or C 1-5 alkyl; and Y is -CH 2 OH or -COOR 4 in which R 4 is H, 1/v (M) where M is a metal of valency v, or a group of formula wherein n is an integer of 1 to 5 and R 5 and R 6 are each H, C 1-5 alkyl, C 3-7 cycloalkyl, aryl or aralkyl, or NR 5 R 6 forms an N-heterocyclic group with 5 to 7 ring members, which heterocyclic group optionally contains a second heteroatom and/or one or more substituents, or a pharmaceutically acceptable addition salt of compound of formula (I). In examples, the acids are prepared by (a) hydrolysing the nitriles or a thionoacetic acid morpholide; (b) reducing indan- 5-glyoxylic acids (themselves made by hydrolysing the Et sters); or (c) hydrogenating alphaalkylidene-indan-5-acetic acids. The aminoalkyl esters are prepared from either the acid chlorides+R 5 R 6 N(CH 2 ) n OH or the acids as Na salts + R 5 R 6 N(CH 2 ) n Cl. The alcohols (Y = CH 2 OH) are prepared by reducing the acids. Starting materials and intermediates otherwise prepared have the formulae where R is 2-isopropyl-5-indaryl, Z is 1,3- dimethyl-5-indaryl and X is substituted 5- indaryl. Therapeutic compositions having analgesic and antiinflammatory activity comprise compounds of the above formula, and may be administered orally, parenterally or rectally.
GB5726/74A 1974-02-07 1974-02-07 Indane derivatives Expired GB1492175A (en)

Priority Applications (43)

Application Number Priority Date Filing Date Title
GB5726/74A GB1492175A (en) 1974-02-07 1974-02-07 Indane derivatives
AR257486A AR206619A1 (en) 1974-02-07 1975-01-01 PROCEDURE FOR PEPARING 5-INDANILACETIC ACIDS
AR257487A AR206620A1 (en) 1974-02-07 1975-01-01 PROCEDURE FOR PREPARING 5-INDANILACETIC ACIDS
FR7501002A FR2260334A1 (en) 1974-02-07 1975-01-14 Indanes e.g. (5-(1,3-dimethyl)indanyl) acetic acid, alcohols and amine - used as antiinflammatory and analgesic agents
BE2054092A BE824522A (en) 1974-02-07 1975-01-20 NEW DERIVATIVES OF INDANE THAT CAN BE USED IN PARTICULAR AS MEDICINAL PRODUCTS
NO750175A NO750175L (en) 1974-02-07 1975-01-21
NO750176A NO146136C (en) 1974-02-07 1975-01-21 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE INHANDER DERIVATIVES
AT75775A AT335445B (en) 1974-02-07 1975-02-03 PROCESS FOR THE PRODUCTION OF NEW INDANYL CARBON ACID DERIVATIVES
AT75675A AT337678B (en) 1974-02-07 1975-02-03 PROCESS FOR THE PREPARATION OF NEW INDANYLACLAVIGOUS ACIDS AND THEIR METAL SALTS
ZA00750707A ZA75707B (en) 1974-02-07 1975-02-04 Indane derivatives
DE19752504689 DE2504689A1 (en) 1974-02-07 1975-02-05 INDANDERIVATES
ES434478A ES434478A1 (en) 1974-02-07 1975-02-05 Process for preparing indane derivatives
ES434479A ES434479A1 (en) 1974-02-07 1975-02-05 Indane derivatives
AU77936/75A AU493675B2 (en) 1974-02-07 1975-02-05 Indane derivatives
CA219,396A CA1063618A (en) 1974-02-07 1975-02-05 Indane derivatives
CH141875A CH603533A5 (en) 1974-02-07 1975-02-06
CH141775A CH605567A5 (en) 1974-02-07 1975-02-06
HUHE000676 HU170419B (en) 1974-02-07 1975-02-06
DD189368A DD123319A5 (en) 1974-02-07 1975-02-06
DK42575*#A DK42575A (en) 1974-02-07 1975-02-06
HUHE000677 HU170420B (en) 1974-02-07 1975-02-06
DK42475*#A DK42475A (en) 1974-02-07 1975-02-06
SE7501339A SE418177B (en) 1974-02-07 1975-02-06 PROCEDURE FOR PREPARING 2-METHYL- (2-ISOPROPYLINDAN-5-YL) -ETIC ACETIC ACID
SU752108439A SU913936A3 (en) 1974-02-07 1975-02-06 Process for producing substituted indanylacetic acids or their salts
DD184040A DD118271A5 (en) 1974-02-07 1975-02-06
DD184036A DD117209A5 (en) 1974-02-07 1975-02-06
SE7501338A SE418395B (en) 1974-02-07 1975-02-06 PROCEDURE FOR THE PREPARATION OF INDANETIC ACIDS
NL7501519A NL7501519A (en) 1974-02-07 1975-02-07 INDIAN DERIVATIVES WITH PHARMACOLOGICAL ACTION.
JP50016776A JPS51125367A (en) 1974-02-07 1975-02-07 Process for preparing indane derivatives
JP50016777A JPS51125368A (en) 1974-02-07 1975-02-07 Process for preparing indane derivatives
NL7501518A NL7501518A (en) 1974-02-07 1975-02-07 INDIAN DERIVATIVES WITH PHARMACOLOGICAL ACTION.
SU762303159A SU895280A3 (en) 1974-02-07 1976-01-04 Method of preparing indan derivatives
AT367176A AT343644B (en) 1974-02-07 1976-05-20 PROCESS FOR THE PREPARATION OF NEW AMINO ALKYLESTERS OF INDANYL CARBONIC ACIDS
US05/690,390 US4088787A (en) 1974-02-07 1976-05-27 Indane ethanols
US05/690,391 US4069326A (en) 1974-02-07 1976-05-27 Morpholino containing indane acetic acid esters
AR263699A AR211541A1 (en) 1974-02-07 1976-06-23 PROCEDURE FOR PREPARING 5-INDANIL-ACETIC ACIDS
AR263744A AR206862A1 (en) 1974-02-07 1976-06-25 PROCEDURE FOR PREPARING 2-ALKYL- (5-INDANIL) -ACETICAL ACIDS
AT495576A AT343106B (en) 1974-02-07 1976-07-07 PROCESS FOR THE PREPARATION OF NEW AMINO ALKYLESTERS OF INDANYL CARBONIC ACIDS
AT495676A AT343646B (en) 1974-02-07 1976-07-07 PROCESS FOR THE PREPARATION OF NEW INDANYLACYL ACIDS AND THEIR SALTS
ES452657A ES452657A1 (en) 1974-02-07 1976-10-22 Indane derivatives
US05/788,033 US4182896A (en) 1974-02-07 1977-04-15 Indane derivatives
SE7713839A SE7713839L (en) 1974-02-07 1977-12-06 PROCEDURE FOR THE PREPARATION OF INDANDERIVATIVES WITH THERAPEUTIC EFFECT
NO800268A NO800268L (en) 1974-02-07 1980-02-01 PROCEDURE FOR THE PREPARATION OF INTERMEDIATE PRODUCTS FOR USE IN THE PREPARATION OF NEW INDANDER DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5726/74A GB1492175A (en) 1974-02-07 1974-02-07 Indane derivatives

Publications (1)

Publication Number Publication Date
GB1492175A true GB1492175A (en) 1977-11-16

Family

ID=9801482

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5726/74A Expired GB1492175A (en) 1974-02-07 1974-02-07 Indane derivatives

Country Status (6)

Country Link
AT (1) AT337678B (en)
BE (1) BE824522A (en)
ES (2) ES434479A1 (en)
GB (1) GB1492175A (en)
SU (2) SU913936A3 (en)
ZA (1) ZA75707B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6985943B2 (en) 1998-09-11 2006-01-10 Genesys Telecommunications Laboratories, Inc. Method and apparatus for extended management of state and interaction of a remote knowledge worker from a contact center

Also Published As

Publication number Publication date
ES434479A1 (en) 1977-03-16
ATA75675A (en) 1976-11-15
ZA75707B (en) 1976-01-28
ES452657A1 (en) 1977-11-16
BE824522A (en) 1975-05-15
AT337678B (en) 1977-07-11
SU895280A3 (en) 1981-12-30
SU913936A3 (en) 1982-03-15

Similar Documents

Publication Publication Date Title
ES344357A1 (en) Cyclopropanecarboxylic acid esters
GB1497044A (en) Salts of phenyl-alkanoic acids
SE7807810L (en) 3-METHYLENIC LAMIC ACID DERIVATIVE
ES368169A1 (en) 3-aryloxyalkylpiperidine derivatives
GB1467110A (en) 4-phenyl-5-oxo-heptenoic acids
GB1121027A (en) New carboxylic acid derivatives, processes for the preparation thereof and compositions containing the same
GB1492175A (en) Indane derivatives
GB999589A (en)
GB1265279A (en)
ES479570A1 (en) 7 alpha -Methoxycephalosporin derivatives and their pharmaceutical compositions having antibacterial activity
GB1164555A (en) New Tropine Derivatives
IE42161L (en) Pyrano-quinoline carboxylic acids
GB1464431A (en) Indolobenzazepine derivatives and a process for the manufacture thereof
ES337591A1 (en) Novel acrylic acid derivatives and process for the preparation thereof
GB1382996A (en) Substituted biphenyls
GB700391A (en) Improvements in or relating to basic esters and processes for preparing the same
SE8703494D0 (en) INTERMEDIATES USEFUL IN THE PREPARATION OF 2-THIOFENEETIC ACETIC ACID DERIVATIVES
GB1266780A (en)
ES365518A1 (en) Derivatives of bis-(p-chlorophenoxy) acetic acid
GB1444870A (en) Pyrazoline derivatives
GB1138873A (en) [(1-alkenylsulfonyl)-phenoxy] alkanoic acids and derivatives thereof
GB1084439A (en) Improvements in or relating to heteroeyclic compounds and the manufacture thereof
GB1410852A (en) Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them
ES343389A1 (en) (4-(2-(alkoxymethyl)alkanoyl)phenoxy)acetic acids and derivatives thereof
GB1174305A (en) Improvements in or relating to Biguanides

Legal Events

Date Code Title Description
PS Patent sealed
746 Register noted 'licences of right' (sect. 46/1977)