GB999589A - - Google Patents
Info
- Publication number
- GB999589A GB999589A GB6141/62A GB614162A GB999589A GB 999589 A GB999589 A GB 999589A GB 6141/62 A GB6141/62 A GB 6141/62A GB 614162 A GB614162 A GB 614162A GB 999589 A GB999589 A GB 999589A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- compounds
- naphthyl
- alkali
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention comprises compounds of general formula <FORM:0999589/C2/1> wherein n is 1 or 3, R1 is 1-naphthyl or 1-naphthylmethyl, R2 is furyl or tetrahydrofuryl or, when n is 1 and R1 is 1-naphthyl, vinyl or 1propenyl, and R3 is hydrogen, alkyl or dialkylaminoethyl; and the sodium salts of the acids; and their preparation by (1) saponifying and decarboxylating a compound <FORM:0999589/C2/2> where R is alkyl (1-4 C), by an alkali in the presence of an alcohol, or (2) hydrolysis of a compound <FORM:0999589/C2/3> by an alkali in the presence of an alcohol, and (3), as exemplified, including forming the esters from the acids. Disubstituted malonates II and nitriles III may be prepared by reacting the monosubstituted compound as its sodium derivative with the chloride or bromide of the required substituent. Pharmaceutical compositions comprise compounds I and salts of the invention in association with pharmaceutical carriers. Oral, rectal and parenteral administration is mentioned, the compounds having hypocholesteraemic, choleretic, psychoenergetic, spasmolytic and antiinflammatory activities. Specification 999,590 is referred to.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR853642A FR1289597A (en) | 1961-02-23 | 1961-02-23 | New alpha-substituted carboxylic acids with at least one cyclic radical and their preparation processes |
FR860401A FR80103E (en) | 1961-02-23 | 1961-04-28 | New alpha-substituted carboxylic acids with at least one cyclic radical and their preparation processes |
FR862174A FR1318M (en) | 1961-05-16 | 1961-05-16 | New alpha-substituted carboxylic acids with hypocholesterolemic properties. |
FR885619A FR81162E (en) | 1962-01-23 | 1962-01-23 | New alpha-substituted carboxylic acids with at least one cyclic radical and their preparation processes |
Publications (1)
Publication Number | Publication Date |
---|---|
GB999589A true GB999589A (en) | 1965-07-28 |
Family
ID=27445280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB6141/62A Expired GB999589A (en) | 1961-02-23 | 1962-02-16 |
Country Status (6)
Country | Link |
---|---|
US (1) | US3257420A (en) |
BE (1) | BE613547A (en) |
CH (2) | CH447200A (en) |
DE (3) | DE1693019B2 (en) |
GB (1) | GB999589A (en) |
NL (1) | NL274986A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2003363A1 (en) | 1969-01-30 | 1970-08-06 | Ciba Geigy | Process for dyeing and printing textiles with Kuepen- and reactive dyes |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3445574A (en) * | 1962-09-20 | 1969-05-20 | Lipha | Compositions and method for arresting spasms with the diethylaminoethyl ester of beta-(1-naphthyl)-beta'-tetrahydrofurylisobutyric acid |
NL295854A (en) * | 1962-12-04 | |||
GB1217689A (en) * | 1967-08-14 | 1970-12-31 | Guppo Lepetit S P A | Ethyl esters of fluro-acetic acids |
US3686307A (en) * | 1969-02-07 | 1972-08-22 | Standard Oil Co | Conversion of nitriles to amides in the presence of alkaline catalysts |
US3956323A (en) * | 1972-01-03 | 1976-05-11 | Hoffmann-La Roche Inc. | Furan, benzofuran and tetrahydrofuran carboxylic acid esters |
GB1540917A (en) * | 1976-08-06 | 1979-02-21 | Wassermann Spa A | Furan derivatives for use as pharmaceutical products particularly for the treatment of rheumatic illnesses and a method for their preparation |
DE2733181B2 (en) * | 1977-07-22 | 1979-08-30 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Process for the preparation of N-substituted α-ketocarboxamides |
FR2580502B1 (en) * | 1985-04-23 | 1988-07-08 | Lipha | USE OF "NAFTIDROFURYL" IN THE PREPARATION OF A MEDICINAL PRODUCT |
US5329054A (en) * | 1993-07-19 | 1994-07-12 | Albemarle Corporation | Decarboxylation process |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2841594A (en) * | 1958-07-01 | Production of beta-furoic acids | ||
US2937117A (en) * | 1953-06-19 | 1960-05-17 | Chimie Atomistique | Process for lowering high blood cholesterol levels |
FR1109144A (en) * | 1954-07-13 | 1956-01-23 | Air Liquide | Ester preparation process |
US2834789A (en) * | 1955-02-15 | 1958-05-13 | Sadolin & Holmblad As | Process of preparing lower lakyl 2, 3, 6-trihydroxybenzoate, and intermediates therefor |
US3057777A (en) * | 1957-10-28 | 1962-10-09 | Lilly Co Eli | Method of reducing cholesterol level of the blood |
US3013023A (en) * | 1959-02-27 | 1961-12-12 | Ueno Ryuzo | Process for the production of 5-nitrofuryl acrylic acid |
US3060198A (en) * | 1959-10-06 | 1962-10-23 | Du Pont | Tetracyanofuran |
-
0
- NL NL274986D patent/NL274986A/xx unknown
-
1962
- 1962-02-01 CH CH245966A patent/CH447200A/en unknown
- 1962-02-01 CH CH128462A patent/CH464172A/en unknown
- 1962-02-06 BE BE613547A patent/BE613547A/en unknown
- 1962-02-16 GB GB6141/62A patent/GB999589A/en not_active Expired
- 1962-02-17 DE DE1693019*CA patent/DE1693019B2/en active Granted
- 1962-02-21 US US174684A patent/US3257420A/en not_active Expired - Lifetime
- 1962-12-17 DE DE1962L0041255 patent/DE1493912A1/en active Pending
-
1964
- 1964-11-13 DE DE1964L0049288 patent/DE1493933A1/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2003363A1 (en) | 1969-01-30 | 1970-08-06 | Ciba Geigy | Process for dyeing and printing textiles with Kuepen- and reactive dyes |
Also Published As
Publication number | Publication date |
---|---|
DE1693019A1 (en) | 1972-03-30 |
NL274986A (en) | |
CH464172A (en) | 1968-10-31 |
CH447200A (en) | 1967-11-30 |
DE1493933A1 (en) | 1969-06-04 |
BE613547A (en) | 1962-08-06 |
US3257420A (en) | 1966-06-21 |
DE1493912A1 (en) | 1969-07-10 |
DE1693019B2 (en) | 1975-11-13 |
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