ID26210A - Proses pemurnian turunan sefalosporin - Google Patents
Proses pemurnian turunan sefalosporinInfo
- Publication number
- ID26210A ID26210A IDW20001932A ID20001932A ID26210A ID 26210 A ID26210 A ID 26210A ID W20001932 A IDW20001932 A ID W20001932A ID 20001932 A ID20001932 A ID 20001932A ID 26210 A ID26210 A ID 26210A
- Authority
- ID
- Indonesia
- Prior art keywords
- purification
- sefalosporin
- cefixime
- purification process
- ceph
- Prior art date
Links
- 238000000746 purification Methods 0.000 title abstract 3
- OKBVVJOGVLARMR-QSWIMTSFSA-N cefixime Chemical compound S1C(N)=NC(C(=N\OCC(O)=O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 OKBVVJOGVLARMR-QSWIMTSFSA-N 0.000 abstract 2
- 229960002129 cefixime Drugs 0.000 abstract 2
- GQLGFBRMCCVQLU-XCGJVMPOSA-N (6r)-7-amino-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(C=C)=C(C(O)=O)N2C(=O)C(N)[C@H]21 GQLGFBRMCCVQLU-XCGJVMPOSA-N 0.000 abstract 1
- QIJIUJYANDSEKG-UHFFFAOYSA-N 2,4,4-trimethylpentan-2-amine Chemical class CC(C)(C)CC(C)(C)N QIJIUJYANDSEKG-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000005580 one pot reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0057598A AT406773B (de) | 1998-04-02 | 1998-04-02 | Neues salz von 7-(2-(aminothiazol-4yl)-2- |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID26210A true ID26210A (id) | 2000-12-07 |
Family
ID=3494225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW20001932A ID26210A (id) | 1998-04-02 | 1999-03-31 | Proses pemurnian turunan sefalosporin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6825345B2 (de) |
| EP (1) | EP1068211B1 (de) |
| JP (1) | JP2002510694A (de) |
| KR (1) | KR20010034671A (de) |
| CN (1) | CN1134447C (de) |
| AT (2) | AT406773B (de) |
| AU (1) | AU3603599A (de) |
| BR (1) | BR9909898A (de) |
| CA (1) | CA2326441C (de) |
| DE (1) | DE69937143T2 (de) |
| ES (1) | ES2293720T3 (de) |
| ID (1) | ID26210A (de) |
| TR (1) | TR200002838T2 (de) |
| WO (1) | WO1999051607A2 (de) |
| ZA (1) | ZA200004899B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT404727B (de) * | 1997-01-16 | 1999-02-25 | Biochemie Gmbh | Kristallines salz von cefixim und verfahren zu dessen herstellung |
| ITMI20012364A1 (it) * | 2001-11-09 | 2003-05-09 | Antibioticos Spa | Processo di sintesi della cefixima via alchil-o arilsolfonati |
| WO2004046154A1 (en) * | 2002-11-15 | 2004-06-03 | Orchid Chemicals & Pharmaceuticals Ltd | Novel amorphous hydrate of a cephalosporin antibiotic |
| US7662955B2 (en) * | 2003-03-20 | 2010-02-16 | Orchid Chemicals And Pharmaceuticals Ltd. | Process for the preparation of cefoxitin |
| WO2006067806A1 (en) * | 2004-12-21 | 2006-06-29 | Lupin Limited | Process for the preparation of cefixime |
| ES2334685T3 (es) * | 2005-03-29 | 2010-03-15 | Hetero Drugs Limited | Procedimiento mejorado de preparacion de cefixima. |
| CN1312158C (zh) * | 2005-05-20 | 2007-04-25 | 天津市医药集团技术发展有限公司 | 一种头孢克肟的制备方法 |
| CN101812075B (zh) * | 2010-05-07 | 2012-06-13 | 郝志艳 | 一种头孢克肟化合物及其新制法 |
| CN103265562A (zh) * | 2013-05-29 | 2013-08-28 | 四川方向药业有限责任公司 | 头孢克肟的制备方法 |
| CN103965216A (zh) * | 2014-05-21 | 2014-08-06 | 广州白云山制药股份有限公司广州白云山化学制药厂 | 7-（噻唑羧甲氧亚氨基)- 3-三嗪环头孢化合物的制造方法 |
| CN103965217A (zh) * | 2014-05-21 | 2014-08-06 | 广州白云山制药股份有限公司广州白云山化学制药厂 | 3-三嗪环-7-（噻唑羧甲氧亚氨基）头孢烷酸的制备方法 |
| WO2016142902A1 (en) * | 2015-03-11 | 2016-09-15 | Lupin Limited | Cefixime with reduced surface area and high stability |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA806977B (en) * | 1979-11-19 | 1981-10-28 | Fujisawa Pharmaceutical Co | 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
| JPS58986A (ja) * | 1981-05-07 | 1983-01-06 | Fujisawa Pharmaceut Co Ltd | セフェム化合物 |
| JPS57192392A (en) * | 1981-05-19 | 1982-11-26 | Sankyo Co Ltd | Production of 3-alkoxymethylcephalosporin |
| AU564150B2 (en) * | 1982-04-30 | 1987-08-06 | Takeda Chemical Industries Ltd. | 1-sulfo-2-azetidinone derivatives |
| DE3377061D1 (en) * | 1982-06-03 | 1988-07-21 | Hoffmann La Roche | Process for the preparation of 1-sulfo-2-oxoazetidine derivatives |
| DE3372768D1 (de) | 1982-06-03 | 1987-09-03 | Hoffmann La Roche | 1-sulfo-2-oxoazetidine derivatives |
| JPS59163387A (ja) * | 1983-03-07 | 1984-09-14 | Sankyo Co Ltd | ３−アルコキシメチルセフアロスポリンの製造方法 |
| JPH0692416B2 (ja) * | 1985-03-13 | 1994-11-16 | 三共株式会社 | セフアロスポラン酸誘導体 |
| US5359057A (en) | 1986-02-07 | 1994-10-25 | Hoffmann-La Roche Inc. | Acylation of amines |
| DE3779768D1 (de) * | 1986-02-07 | 1992-07-23 | Hoffmann La Roche | Verfahren zur herstellung von carbonsaeureamiden. |
| JPH01242589A (ja) * | 1988-03-22 | 1989-09-27 | Fujisawa Pharmaceut Co Ltd | セフエム化合物 |
| PT630380E (pt) * | 1992-02-05 | 2002-02-28 | Biochemie Gmbh | Processo para a purificacao de um derivado do acido 3-cefem-4-carboxilico |
| EP0658558B1 (de) * | 1993-11-17 | 2001-01-24 | Biochemie Gesellschaft M.B.H. | Trennung von Cephalosporinisomeren |
| AT403049B (de) * | 1995-08-14 | 1997-10-27 | Biochemie Gmbh | Abreicherung von 7-adca in 3-vinyl-aca |
| AT404251B (de) * | 1996-08-14 | 1998-10-27 | Biochemie Gmbh | Neues kristallines salz von cefixim |
| EP0831093A1 (de) * | 1996-09-23 | 1998-03-25 | F. Hoffmann-La Roche Ag | 1-Carba-(desthia)-cephalosporinderivate |
| TW538045B (en) * | 1997-01-16 | 2003-06-21 | Biochemie Gmbh | Process for purifying cefixime |
-
1998
- 1998-04-02 AT AT0057598A patent/AT406773B/de not_active IP Right Cessation
-
1999
- 1999-03-31 WO PCT/EP1999/002222 patent/WO1999051607A2/en not_active Ceased
- 1999-03-31 JP JP2000542328A patent/JP2002510694A/ja active Pending
- 1999-03-31 AU AU36035/99A patent/AU3603599A/en not_active Abandoned
- 1999-03-31 ES ES99917938T patent/ES2293720T3/es not_active Expired - Lifetime
- 1999-03-31 TR TR2000/02838T patent/TR200002838T2/xx unknown
- 1999-03-31 CA CA002326441A patent/CA2326441C/en not_active Expired - Fee Related
- 1999-03-31 KR KR1020007010634A patent/KR20010034671A/ko not_active Ceased
- 1999-03-31 DE DE69937143T patent/DE69937143T2/de not_active Expired - Lifetime
- 1999-03-31 EP EP99917938A patent/EP1068211B1/de not_active Expired - Lifetime
- 1999-03-31 BR BR9909898-9A patent/BR9909898A/pt not_active Application Discontinuation
- 1999-03-31 CN CNB998046205A patent/CN1134447C/zh not_active Expired - Fee Related
- 1999-03-31 ID IDW20001932A patent/ID26210A/id unknown
- 1999-03-31 AT AT99917938T patent/ATE373666T1/de not_active IP Right Cessation
-
2000
- 2000-09-14 ZA ZA200004899A patent/ZA200004899B/xx unknown
-
2002
- 2002-09-30 US US10/261,748 patent/US6825345B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20030208065A1 (en) | 2003-11-06 |
| ATE373666T1 (de) | 2007-10-15 |
| ATA57598A (de) | 2000-01-15 |
| HK1034078A1 (en) | 2001-10-12 |
| BR9909898A (pt) | 2000-12-26 |
| ZA200004899B (en) | 2001-12-24 |
| WO1999051607A3 (en) | 2000-01-27 |
| TR200002838T2 (tr) | 2001-02-21 |
| KR20010034671A (ko) | 2001-04-25 |
| EP1068211A2 (de) | 2001-01-17 |
| DE69937143D1 (de) | 2007-10-31 |
| JP2002510694A (ja) | 2002-04-09 |
| DE69937143T2 (de) | 2008-06-12 |
| EP1068211B1 (de) | 2007-09-19 |
| ES2293720T3 (es) | 2008-03-16 |
| CA2326441C (en) | 2008-03-18 |
| AT406773B (de) | 2000-08-25 |
| CA2326441A1 (en) | 1999-10-14 |
| US6825345B2 (en) | 2004-11-30 |
| AU3603599A (en) | 1999-10-25 |
| CN1134447C (zh) | 2004-01-14 |
| WO1999051607A2 (en) | 1999-10-14 |
| CN1295576A (zh) | 2001-05-16 |
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