ID26208A - Turunan-turunan asam amino amidino terhalogenasi yang berguna sebagai penghambat sintase nitrat oksida - Google Patents

Turunan-turunan asam amino amidino terhalogenasi yang berguna sebagai penghambat sintase nitrat oksida

Info

Publication number
ID26208A
ID26208A IDW20001739A ID20001739A ID26208A ID 26208 A ID26208 A ID 26208A ID W20001739 A IDW20001739 A ID W20001739A ID 20001739 A ID20001739 A ID 20001739A ID 26208 A ID26208 A ID 26208A
Authority
ID
Indonesia
Prior art keywords
acid
synthase
resident
halogenation
drugs
Prior art date
Application number
IDW20001739A
Other languages
English (en)
Indonesian (id)
Inventor
Ann E Hallinan
Barnett S Pitzel
Dale P Spangler
Arija A Bergmanis
Timothy J Hagen
Sofya Tsymbalov
Mihaly V Toth
Keith R Webber
Donald W Hansen Jr
Alik K Awasthi
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of ID26208A publication Critical patent/ID26208A/id

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
IDW20001739A 1998-03-11 1999-03-04 Turunan-turunan asam amino amidino terhalogenasi yang berguna sebagai penghambat sintase nitrat oksida ID26208A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3828498A 1998-03-11 1998-03-11

Publications (1)

Publication Number Publication Date
ID26208A true ID26208A (id) 2000-11-07

Family

ID=21899068

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20001739A ID26208A (id) 1998-03-11 1999-03-04 Turunan-turunan asam amino amidino terhalogenasi yang berguna sebagai penghambat sintase nitrat oksida

Country Status (35)

Country Link
US (1) US6344483B1 (uk)
EP (2) EP1415982A1 (uk)
JP (1) JP2002506056A (uk)
KR (1) KR20010034598A (uk)
CN (1) CN1171861C (uk)
AP (1) AP2000001900A0 (uk)
AR (1) AR018159A1 (uk)
AT (1) ATE277894T1 (uk)
AU (1) AU746235B2 (uk)
BG (1) BG104766A (uk)
BR (1) BR9908702A (uk)
CA (1) CA2322873A1 (uk)
CU (1) CU23047A3 (uk)
DE (1) DE69920670T2 (uk)
EA (1) EA200000826A1 (uk)
EE (1) EE200000519A (uk)
ES (1) ES2239839T3 (uk)
GE (1) GEP20043179B (uk)
HR (1) HRP20000595A2 (uk)
HU (1) HUP0101467A3 (uk)
ID (1) ID26208A (uk)
IL (1) IL137654A0 (uk)
IS (1) IS5583A (uk)
NO (1) NO20004531L (uk)
NZ (1) NZ506721A (uk)
OA (1) OA11901A (uk)
PL (1) PL343380A1 (uk)
PT (1) PT1062201E (uk)
SI (1) SI1062201T1 (uk)
SK (1) SK13012000A3 (uk)
TR (1) TR200002605T2 (uk)
UA (1) UA67767C2 (uk)
WO (1) WO1999046240A2 (uk)
YU (1) YU52200A (uk)
ZA (1) ZA991894B (uk)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200206459B (en) 2000-03-24 2003-08-13 Pharmacia Corp Amidino compound and salts thereof useful as nitric oxide synthase inhibitors.
AR032318A1 (es) * 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
AR034120A1 (es) 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
AR030416A1 (es) 2000-04-13 2003-08-20 Pharmacia Corp COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
US6787668B2 (en) 2000-04-13 2004-09-07 Pharmacia Corporation 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
US6956131B2 (en) * 2000-04-13 2005-10-18 Pharmacia Corporation 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
US6545170B2 (en) 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR031609A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de acido 2-amino-2-alquil-3 heptenoico y heptinoico utiles como inhibidores de oxido nitrico sintetasa
AR031129A1 (es) * 2000-09-15 2003-09-10 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR035585A1 (es) * 2000-09-15 2004-06-16 Pharmacia Corp Derivados del acido 2-amino-2-alquil-4-heptenoico, composicion farmaceutica y su uso en la fabricacion de medicamentos
AR031608A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
GB0031179D0 (en) 2000-12-21 2001-01-31 Glaxo Group Ltd Nitric oxide synthase inhibitors
US6613280B2 (en) * 2001-03-20 2003-09-02 Therox, Inc. Disposable cartridge for producing gas-enriched fluids
US6582387B2 (en) * 2001-03-20 2003-06-24 Therox, Inc. System for enriching a bodily fluid with a gas
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
MXPA04011335A (es) * 2002-05-16 2005-07-01 Pharmacia Corp Metodos para el tratamiento de enfermedades y afecciones respiratorias con un inhibidor selectivo de inos y un inhibidor de pde y composiciones para esto.
CA3005835C (en) * 2004-12-22 2023-01-31 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
CN101175726A (zh) * 2005-03-14 2008-05-07 詹森药业有限公司 阿片样物质调节剂的制备方法
NZ567234A (en) 2005-11-08 2011-09-30 Ambrx Inc Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
CA2631491C (en) 2005-12-14 2015-02-24 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
KR101103720B1 (ko) * 2011-06-02 2012-01-11 한국건설기술연구원 자연환기에 의한 중공층의 온도제어가 가능한 일체형 다중유리 복합창짝
CN111732652A (zh) 2013-09-09 2020-10-02 卡尼姆盖德治疗学公司 免疫系统调节器
CA2978617A1 (en) 2015-03-06 2016-09-15 Canimguide Therapeutics Ab Immune system modulators and compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
AU692892B2 (en) * 1994-06-15 1998-06-18 Wellcome Foundation Limited, The Enzyme inhibitors
GB9425701D0 (en) 1994-12-20 1995-02-22 Wellcome Found Enzyme inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors

Also Published As

Publication number Publication date
OA11901A (en) 2006-04-10
CU23047A3 (es) 2005-04-26
EP1062201A2 (en) 2000-12-27
EA200000826A1 (ru) 2001-04-23
WO1999046240A2 (en) 1999-09-16
KR20010034598A (ko) 2001-04-25
JP2002506056A (ja) 2002-02-26
DE69920670T2 (de) 2006-02-16
AR018159A1 (es) 2001-10-31
EP1062201B1 (en) 2004-09-29
HRP20000595A2 (en) 2001-04-30
NO20004531L (no) 2000-10-30
IS5583A (is) 2000-08-04
BG104766A (bg) 2001-03-30
US6344483B1 (en) 2002-02-05
BR9908702A (pt) 2000-11-21
AU2778699A (en) 1999-09-27
EE200000519A (et) 2002-02-15
ZA991894B (en) 1999-09-27
DE69920670D1 (de) 2004-11-04
SK13012000A3 (sk) 2001-06-11
TR200002605T2 (tr) 2000-12-21
UA67767C2 (uk) 2004-07-15
CA2322873A1 (en) 1999-09-16
AP2000001900A0 (en) 2000-09-30
YU52200A (sh) 2002-09-19
CN1171861C (zh) 2004-10-20
GEP20043179B (en) 2004-02-25
PT1062201E (pt) 2005-02-28
SI1062201T1 (en) 2005-10-31
PL343380A1 (en) 2001-08-13
IL137654A0 (en) 2001-10-31
NO20004531D0 (no) 2000-09-11
AU746235B2 (en) 2002-04-18
HUP0101467A2 (hu) 2001-08-28
CN1292779A (zh) 2001-04-25
HUP0101467A3 (en) 2003-03-28
NZ506721A (en) 2003-07-25
WO1999046240A3 (en) 1999-11-11
ES2239839T3 (es) 2005-10-01
ATE277894T1 (de) 2004-10-15
EP1415982A1 (en) 2004-05-06

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