ID19401A - N-sianoimina trisiklik baru yang berguna sebagai inhibitor farnesil-protein transferase - Google Patents

N-sianoimina trisiklik baru yang berguna sebagai inhibitor farnesil-protein transferase

Info

Publication number
ID19401A
ID19401A IDP972631A ID972631A ID19401A ID 19401 A ID19401 A ID 19401A ID P972631 A IDP972631 A ID P972631A ID 972631 A ID972631 A ID 972631A ID 19401 A ID19401 A ID 19401A
Authority
ID
Indonesia
Prior art keywords
protein transferase
trisiclic
sianoimina
farnesil
new
Prior art date
Application number
IDP972631A
Other languages
English (en)
Indonesian (id)
Inventor
Alan B Cooper
James J-S Wang
Raymond G Lovey
Jagdish A Desai
Anil K Saksena
Viyyoor M Girijavallabhan
Ronald J Doll
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ID19401A publication Critical patent/ID19401A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IDP972631A 1996-07-31 1997-07-29 N-sianoimina trisiklik baru yang berguna sebagai inhibitor farnesil-protein transferase ID19401A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69052296A 1996-07-31 1996-07-31

Publications (1)

Publication Number Publication Date
ID19401A true ID19401A (id) 1998-07-09

Family

ID=24772812

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP972631A ID19401A (id) 1996-07-31 1997-07-29 N-sianoimina trisiklik baru yang berguna sebagai inhibitor farnesil-protein transferase

Country Status (13)

Country Link
EP (1) EP0915869B1 (ja)
JP (1) JP3153555B2 (ja)
CN (1) CN1117745C (ja)
AT (1) ATE240313T1 (ja)
AU (1) AU3737097A (ja)
CA (1) CA2261724C (ja)
CO (1) CO4900031A1 (ja)
DE (1) DE69722002T2 (ja)
ES (1) ES2194207T3 (ja)
ID (1) ID19401A (ja)
PE (1) PE92098A1 (ja)
WO (1) WO1998004545A1 (ja)
ZA (1) ZA976754B (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1326850C (zh) * 1998-12-18 2007-07-18 先灵公司 三环类法尼基蛋白转移酶抑制剂
AR033680A1 (es) * 2000-08-30 2004-01-07 Schering Corp Compuestos triciclicos utiles como inhibidores de la farnesil proteino transferasa y su uso para la manufactura de medicamentos como agentes antitumorales
CN102731476A (zh) * 2012-05-29 2012-10-17 安徽宏业药业有限公司 含氰胍结构的苯并环庚基吡啶衍生物、制备方法、药物组合物及其医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
JPH0678315B2 (ja) * 1988-04-28 1994-10-05 シェリング・コーポレーション 新規なベンゾピリド‐ピペリジン、ピペリジリデンおよびピペラジン化合物、組成物、製造法および利用法
DE69429438T2 (de) * 1993-10-15 2002-08-08 Schering Corp., Kenilworth Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them

Also Published As

Publication number Publication date
CN1117745C (zh) 2003-08-13
ZA976754B (en) 1998-02-02
JP2000500783A (ja) 2000-01-25
WO1998004545A1 (en) 1998-02-05
ES2194207T3 (es) 2003-11-16
EP0915869B1 (en) 2003-05-14
CA2261724C (en) 2003-05-13
DE69722002D1 (de) 2003-06-18
PE92098A1 (es) 1998-12-31
CN1226246A (zh) 1999-08-18
CO4900031A1 (es) 2000-03-27
AU3737097A (en) 1998-02-20
ATE240313T1 (de) 2003-05-15
DE69722002T2 (de) 2004-04-01
EP0915869A1 (en) 1999-05-19
CA2261724A1 (en) 1998-02-05
JP3153555B2 (ja) 2001-04-09

Similar Documents

Publication Publication Date Title
MX9707562A (es) Compuestos triciclicos utiles para inhibir la funcion de la proteina g y para el tratamiento de enfermedades proliferativas.
CA2293706A1 (en) N-substituted urea inhibitors of farnesyl-protein transferase
MX9707732A (es) Compuestos triciclicos utiles en el tratamiento de desordenes proliferativos de celulas.
MX9707665A (es) Compuestos triciclicos utiles para inhibir la funcion de la proteina g y para el tratamiento de enfermedades proliferativas.
MY129998A (en) Saccharin derivative proteolytic enzyme inhibitors
ES2194986T3 (es) Compuestos de carbonil-piperazinilo y piperidinilo que inhiben la farnesil-protein-transferasa.
MY110104A (en) Saccharin derivative proteolytic enzyme inhibitors
MX9707197A (es) Compuestos triciclicos de urea que son utiles para la inhibicion de la funcion de la proteina g y para tratamiento de enfermedades proliferativas.
GEP20022616B (en) (54) Azepin Derivatives to Inhibiting Farnesyl Protein Transferase and Method for Treatment
BG103995A (en) Reverse hydroxamate inhibitors of matrix metalloprreverse hydroxamate inhibitors of matrix metallprooteinases teinases
MY143570A (en) Compounds useful for inhibition of farnesyl protein transferase
MX9708452A (es) Inhibidores de sialidasa bacteriana y metodos para fabricar y usar la misma.
CA2266759A1 (en) 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
TR199901274T2 (xx) Farnezil protein transferaz inhibit�rleri olarak yararl� yeni trisiklik piperidinil bile�ikleri
DE69926078D1 (en) Farnesyl-protein transferase inhibitoren
CA2293358A1 (en) Tricyclic sulfonamide inhibitors of farnesyl-protein transferase
ID19401A (id) N-sianoimina trisiklik baru yang berguna sebagai inhibitor farnesil-protein transferase
HK1023339A1 (en) Novel aminooxyamide tricyclic inhibitors of farnesylprotein transferase
CA2293549A1 (en) Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase
FI970565A (fi) HIV-proteaasia inhiboiva yhdistelmä
CA2293713A1 (en) Bispyrido-cycloheptane compounds useful for inhibition of farnesyl protein transferase
MX9707232A (es) Compuestos triciclicos de amida y urea, utiles para la inhibicion de la funcion de la proteina g y para el tratamiento de enfermedades proliferativas.
ECSP982531A (es) Novedosos inhibidores de urea - n - sustituida de transferasa de proteina, farnesilo (case in0728)
ECSP982536A (es) Compuestos utiles para la inhibicion de transferasa de proteina al farnesilo ( case ino750k)