HUT77174A - Heterociklusos csoporttal szubsztituált 3-(indol-3-il)-akrilsav-származékok, mint NMDA antagonisták, és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Heterociklusos csoporttal szubsztituált 3-(indol-3-il)-akrilsav-származékok, mint NMDA antagonisták, és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUT77174A HUT77174A HU9701941A HU9701941A HUT77174A HU T77174 A HUT77174 A HU T77174A HU 9701941 A HU9701941 A HU 9701941A HU 9701941 A HU9701941 A HU 9701941A HU T77174 A HUT77174 A HU T77174A
- Authority
- HU
- Hungary
- Prior art keywords
- acid derivatives
- propenoic acid
- pharmaceutical compositions
- indol
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08332016 US5563157B1 (en) | 1994-10-31 | 1994-10-31 | Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof |
| PCT/US1995/012085 WO1996013501A1 (en) | 1994-10-31 | 1995-09-21 | Heterocycle substituted propenoic acid derivatives as nmda antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT77174A true HUT77174A (hu) | 1998-03-02 |
| HU222372B1 HU222372B1 (hu) | 2003-06-28 |
Family
ID=23296353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9701941A HU222372B1 (hu) | 1994-10-31 | 1995-09-21 | Heterociklusos csoporttal szubsztituált 3-(indol-3-il)-akrilsav-származékok, mint NMDA antagonisták, és a vegyületeket tartalmazó gyógyszerkészítmények |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US5563157B1 (hu) |
| EP (1) | EP0790994B1 (hu) |
| JP (1) | JP3934678B2 (hu) |
| KR (1) | KR100401138B1 (hu) |
| CN (1) | CN1068001C (hu) |
| AT (1) | ATE217307T1 (hu) |
| AU (1) | AU696423B2 (hu) |
| CA (1) | CA2202992C (hu) |
| DE (1) | DE69526668T2 (hu) |
| DK (1) | DK0790994T3 (hu) |
| ES (1) | ES2173198T3 (hu) |
| FI (1) | FI971831A0 (hu) |
| HU (1) | HU222372B1 (hu) |
| IL (1) | IL115791A (hu) |
| MX (1) | MX9703146A (hu) |
| NO (1) | NO313197B1 (hu) |
| NZ (1) | NZ293842A (hu) |
| PT (1) | PT790994E (hu) |
| TW (1) | TW336232B (hu) |
| WO (1) | WO1996013501A1 (hu) |
| ZA (1) | ZA959046B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922752A (en) * | 1997-06-11 | 1999-07-13 | Hoechst Marion Roussell, Inc. | NMDA (n-methyl-d-aspartate) antagonists |
| GB9902455D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| CA2427499A1 (en) | 2000-10-10 | 2002-04-18 | Smithkline Beecham Corporation | Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppar-.gamma. binding agents |
| JP2005506292A (ja) * | 2001-03-08 | 2005-03-03 | エモリー ユニバーシティ | ｐＨに依存するＮＭＤＡレセプターアンタゴニスト |
| NZ582917A (en) * | 2007-06-29 | 2013-01-25 | Univ Emory | Nmda receptor antagonists for neuroprotection |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0539503B1 (en) * | 1990-07-16 | 1996-04-03 | Merrell Dow Pharmaceuticals Inc. | Excitatory amino acid antagonists |
| PT99207B (pt) * | 1990-10-15 | 1999-04-30 | Astra Ab | Processo de preparacao de derivados da piperidina e de composicoes farmaceuticas |
| US5284862A (en) * | 1991-03-18 | 1994-02-08 | Warner-Lambert Company | Derivatives of 2-carboxyindoles having pharmaceutical activity |
| GB9208492D0 (en) * | 1992-04-16 | 1992-06-03 | Glaxo Spa | Heterocyclic compounds |
| US5519048A (en) * | 1993-05-27 | 1996-05-21 | Merrell Pharmaceuticals Inc. | 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof |
| DK0701551T3 (da) * | 1993-05-27 | 1997-10-20 | Merrell Pharma Inc | 3-(Indol-3-yl)propensyrederivater som NMDA-antagonister |
-
1994
- 1994-10-31 US US08332016 patent/US5563157B1/en not_active Expired - Lifetime
-
1995
- 1995-09-21 DK DK95933902T patent/DK0790994T3/da active
- 1995-09-21 DE DE69526668T patent/DE69526668T2/de not_active Expired - Lifetime
- 1995-09-21 NZ NZ293842A patent/NZ293842A/en unknown
- 1995-09-21 AU AU36387/95A patent/AU696423B2/en not_active Ceased
- 1995-09-21 HU HU9701941A patent/HU222372B1/hu not_active IP Right Cessation
- 1995-09-21 EP EP95933902A patent/EP0790994B1/en not_active Expired - Lifetime
- 1995-09-21 WO PCT/US1995/012085 patent/WO1996013501A1/en not_active Application Discontinuation
- 1995-09-21 KR KR1019970702840A patent/KR100401138B1/ko not_active IP Right Cessation
- 1995-09-21 CA CA002202992A patent/CA2202992C/en not_active Expired - Lifetime
- 1995-09-21 AT AT95933902T patent/ATE217307T1/de not_active IP Right Cessation
- 1995-09-21 ES ES95933902T patent/ES2173198T3/es not_active Expired - Lifetime
- 1995-09-21 MX MX9703146A patent/MX9703146A/es unknown
- 1995-09-21 JP JP51456396A patent/JP3934678B2/ja not_active Expired - Lifetime
- 1995-09-21 CN CN95195799A patent/CN1068001C/zh not_active Expired - Fee Related
- 1995-09-21 PT PT95933902T patent/PT790994E/pt unknown
- 1995-10-25 ZA ZA959046A patent/ZA959046B/xx unknown
- 1995-10-26 TW TW084111310A patent/TW336232B/zh active
- 1995-10-27 IL IL11579195A patent/IL115791A/xx not_active IP Right Cessation
-
1997
- 1997-04-29 NO NO19971991A patent/NO313197B1/no not_active IP Right Cessation
- 1997-04-29 FI FI971831A patent/FI971831A0/fi not_active IP Right Cessation
- 1997-12-15 US US08/990,673 patent/US5981553A/en not_active Expired - Lifetime
-
1999
- 1999-07-28 US US09/363,305 patent/US6180786B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0790994B1 (en) | 2002-05-08 |
| AU696423B2 (en) | 1998-09-10 |
| FI971831A (fi) | 1997-04-29 |
| TW336232B (en) | 1998-07-11 |
| KR100401138B1 (ko) | 2003-12-24 |
| JP3934678B2 (ja) | 2007-06-20 |
| US5981553A (en) | 1999-11-09 |
| NO971991D0 (no) | 1997-04-29 |
| CN1068001C (zh) | 2001-07-04 |
| IL115791A (en) | 2000-09-28 |
| CA2202992C (en) | 2003-05-13 |
| IL115791A0 (en) | 1996-01-19 |
| AU3638795A (en) | 1996-05-23 |
| EP0790994A1 (en) | 1997-08-27 |
| ATE217307T1 (de) | 2002-05-15 |
| NO313197B1 (no) | 2002-08-26 |
| MX9703146A (es) | 1997-06-28 |
| NO971991L (no) | 1997-04-29 |
| US5563157A (en) | 1996-10-08 |
| JPH10508019A (ja) | 1998-08-04 |
| DE69526668D1 (de) | 2002-06-13 |
| DE69526668T2 (de) | 2003-01-02 |
| WO1996013501A1 (en) | 1996-05-09 |
| US6180786B1 (en) | 2001-01-30 |
| FI971831A0 (fi) | 1997-04-29 |
| PT790994E (pt) | 2002-08-30 |
| CN1161696A (zh) | 1997-10-08 |
| NZ293842A (en) | 1998-09-24 |
| HU222372B1 (hu) | 2003-06-28 |
| DK0790994T3 (da) | 2002-08-26 |
| ZA959046B (en) | 1996-05-17 |
| CA2202992A1 (en) | 1996-05-09 |
| ES2173198T3 (es) | 2002-10-16 |
| US5563157B1 (en) | 1999-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HFG4 | Patent granted, date of granting |
Effective date: 20030417 |
|
| HMM4 | Cancellation of final prot. due to non-payment of fee |