HUT71796A - Condensed cyclic compounds with nitrogen heteroatoms and pharmaceutical compositions of fibrinogen receptor antagonistic activity containing them - Google Patents

Condensed cyclic compounds with nitrogen heteroatoms and pharmaceutical compositions of fibrinogen receptor antagonistic activity containing them Download PDF

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Publication number
HUT71796A
HUT71796A HU9502028A HU9502028A HUT71796A HU T71796 A HUT71796 A HU T71796A HU 9502028 A HU9502028 A HU 9502028A HU 9502028 A HU9502028 A HU 9502028A HU T71796 A HUT71796 A HU T71796A
Authority
HU
Hungary
Prior art keywords
formula
compound
group
mmol
alkyl
Prior art date
Application number
HU9502028A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9502028D0 (en
Inventor
John J Baldwin
David Alan Claremon
Nigel Liverton
Ben Askew
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HU9502028D0 publication Critical patent/HU9502028D0/hu
Publication of HUT71796A publication Critical patent/HUT71796A/hu

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
HU9502028A 1993-02-22 1994-02-22 Condensed cyclic compounds with nitrogen heteroatoms and pharmaceutical compositions of fibrinogen receptor antagonistic activity containing them HUT71796A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2051793A 1993-02-22 1993-02-22

Publications (2)

Publication Number Publication Date
HU9502028D0 HU9502028D0 (en) 1995-09-28
HUT71796A true HUT71796A (en) 1996-02-28

Family

ID=21799049

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9502028A HUT71796A (en) 1993-02-22 1994-02-22 Condensed cyclic compounds with nitrogen heteroatoms and pharmaceutical compositions of fibrinogen receptor antagonistic activity containing them

Country Status (15)

Country Link
EP (1) EP0684823A4 (fr)
JP (1) JP3173792B2 (fr)
KR (1) KR960700722A (fr)
CN (1) CN1118139A (fr)
AU (1) AU680240B2 (fr)
BG (1) BG99863A (fr)
CA (1) CA2155123A1 (fr)
CZ (1) CZ210895A3 (fr)
FI (1) FI953916A (fr)
HU (1) HUT71796A (fr)
NO (1) NO953270L (fr)
NZ (1) NZ262664A (fr)
PL (1) PL310386A1 (fr)
SK (1) SK102495A3 (fr)
WO (1) WO1994018981A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5494921A (en) * 1994-09-16 1996-02-27 Merck & Co., Inc. Fibrinogen receptor antagonists
ZA963391B (en) * 1995-05-24 1997-10-29 Du Pont Merck Pharma Isoxazoline fibrinogen receptor antagonists.
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
ATE203234T1 (de) 1995-08-30 2001-08-15 Searle & Co Meta-guanidine, harnstoff, thioharnstoff oder azacyklische aminobenzoesäure-derivate als integrin antagonisten
US6291469B1 (en) 1995-09-29 2001-09-18 Eli Lilly And Company Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation
CA2240439A1 (fr) * 1995-12-22 1997-07-03 The Dupont Merck Pharmaceutical Company Nouveaux antagonistes de recepteurs d'integrines
WO1997035579A1 (fr) * 1996-03-27 1997-10-02 Merck & Co., Inc. Procede d'inhibition de la formation de caillots
EP0917462B1 (fr) * 1996-07-25 2006-09-13 Biogen Idec MA Inc. Inhibiteurs d'adhesion cellulaire
US5900414A (en) * 1996-08-29 1999-05-04 Merck & Co., Inc. Methods for administering integrin receptor antagonists
DE19653647A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
EP1023295A4 (fr) * 1997-02-06 2001-01-24 Merck & Co Inc Promedicaments antagonistes de recepteur de fibrinogene
WO1998043962A1 (fr) * 1997-03-28 1998-10-08 Du Pont Pharmaceuticals Company Promedicaments heterocycliques inhibiteurs d'integrine
US6303625B1 (en) 1998-07-27 2001-10-16 Ortho-Mcneil Pharmaceutical, Inc. Triazolopyridines for the treatment of thrombosis disorders
DE60041584D1 (de) * 1999-07-28 2009-04-02 Aventis Pharma Inc Substituierte oxoazaheterozyclische verbindungen
AU2003301226A1 (en) * 2002-12-20 2004-07-22 Pharmacia Corp Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2
WO2008006540A1 (fr) * 2006-07-12 2008-01-17 Syngenta Participations Ag Dérivés de triazolpyridine utilisés comme herbicides
WO2009137201A1 (fr) * 2008-04-04 2009-11-12 Cv Therapeutics, Inc. Dérivés de triazolopyridinone destinés à être utilisés comme inhibiteurs de la stéaroyl-coa désaturase
WO2010096722A1 (fr) * 2009-02-20 2010-08-26 Takeda Pharmaceutical Company Limited 3-oxo-2,3-dihydro-[1,2,4]triazolo[4, 3-a]pyridines utilisées comme inhibiteurs de l'époxyde hydrolase soluble (eh soluble)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
GB8913011D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Anticonvulsant pyrazines
US5166154A (en) * 1989-10-17 1992-11-24 Boehringer Ingelheim Pharmaceuticals, Inc. Imidazo[1,2-a]piperazines
US5278161A (en) * 1990-06-28 1994-01-11 Hoffmann-La Roche Inc. Amino acid derivatives useful as renin inhibitors

Also Published As

Publication number Publication date
SK102495A3 (en) 1997-01-08
NO953270L (no) 1995-10-19
FI953916A0 (fi) 1995-08-21
WO1994018981A1 (fr) 1994-09-01
KR960700722A (ko) 1996-02-24
CZ210895A3 (en) 1996-02-14
NZ262664A (en) 1997-04-24
BG99863A (en) 1996-02-29
EP0684823A4 (fr) 1997-07-09
PL310386A1 (en) 1995-12-11
CN1118139A (zh) 1996-03-06
JPH08507072A (ja) 1996-07-30
FI953916A (fi) 1995-08-21
HU9502028D0 (en) 1995-09-28
EP0684823A1 (fr) 1995-12-06
AU680240B2 (en) 1997-07-24
AU6246594A (en) 1994-09-14
NO953270D0 (no) 1995-08-21
CA2155123A1 (fr) 1994-09-01
JP3173792B2 (ja) 2001-06-04

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Legal Events

Date Code Title Description
DFA9 Temporary protection cancelled due to abandonment