EP0684823A4 - Antagonistes des recepteurs de fibrinogene. - Google Patents
Antagonistes des recepteurs de fibrinogene.Info
- Publication number
- EP0684823A4 EP0684823A4 EP94909745A EP94909745A EP0684823A4 EP 0684823 A4 EP0684823 A4 EP 0684823A4 EP 94909745 A EP94909745 A EP 94909745A EP 94909745 A EP94909745 A EP 94909745A EP 0684823 A4 EP0684823 A4 EP 0684823A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- receptor antagonists
- fibrinogen receptor
- fibrinogen
- antagonists
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2051793A | 1993-02-22 | 1993-02-22 | |
US20517 | 1993-02-22 | ||
PCT/US1994/001881 WO1994018981A1 (fr) | 1993-02-22 | 1994-02-22 | Antagonistes des recepteurs de fibrinogene |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0684823A1 EP0684823A1 (fr) | 1995-12-06 |
EP0684823A4 true EP0684823A4 (fr) | 1997-07-09 |
Family
ID=21799049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94909745A Withdrawn EP0684823A4 (fr) | 1993-02-22 | 1994-02-22 | Antagonistes des recepteurs de fibrinogene. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0684823A4 (fr) |
JP (1) | JP3173792B2 (fr) |
KR (1) | KR960700722A (fr) |
CN (1) | CN1118139A (fr) |
AU (1) | AU680240B2 (fr) |
BG (1) | BG99863A (fr) |
CA (1) | CA2155123A1 (fr) |
CZ (1) | CZ210895A3 (fr) |
FI (1) | FI953916A (fr) |
HU (1) | HUT71796A (fr) |
NO (1) | NO953270L (fr) |
NZ (1) | NZ262664A (fr) |
PL (1) | PL310386A1 (fr) |
SK (1) | SK102495A3 (fr) |
WO (1) | WO1994018981A1 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5494921A (en) * | 1994-09-16 | 1996-02-27 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
ZA963391B (en) * | 1995-05-24 | 1997-10-29 | Du Pont Merck Pharma | Isoxazoline fibrinogen receptor antagonists. |
US6100423A (en) * | 1995-08-30 | 2000-08-08 | G. D. Searle & Co. | Amino benzenepropanoic acid compounds and derivatives thereof |
ATE203234T1 (de) | 1995-08-30 | 2001-08-15 | Searle & Co | Meta-guanidine, harnstoff, thioharnstoff oder azacyklische aminobenzoesäure-derivate als integrin antagonisten |
US6291469B1 (en) | 1995-09-29 | 2001-09-18 | Eli Lilly And Company | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
CA2240439A1 (fr) * | 1995-12-22 | 1997-07-03 | The Dupont Merck Pharmaceutical Company | Nouveaux antagonistes de recepteurs d'integrines |
WO1997035579A1 (fr) * | 1996-03-27 | 1997-10-02 | Merck & Co., Inc. | Procede d'inhibition de la formation de caillots |
EP0917462B1 (fr) * | 1996-07-25 | 2006-09-13 | Biogen Idec MA Inc. | Inhibiteurs d'adhesion cellulaire |
US5900414A (en) * | 1996-08-29 | 1999-05-04 | Merck & Co., Inc. | Methods for administering integrin receptor antagonists |
DE19653647A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
EP1023295A4 (fr) * | 1997-02-06 | 2001-01-24 | Merck & Co Inc | Promedicaments antagonistes de recepteur de fibrinogene |
WO1998043962A1 (fr) * | 1997-03-28 | 1998-10-08 | Du Pont Pharmaceuticals Company | Promedicaments heterocycliques inhibiteurs d'integrine |
US6303625B1 (en) | 1998-07-27 | 2001-10-16 | Ortho-Mcneil Pharmaceutical, Inc. | Triazolopyridines for the treatment of thrombosis disorders |
DE60041584D1 (de) * | 1999-07-28 | 2009-04-02 | Aventis Pharma Inc | Substituierte oxoazaheterozyclische verbindungen |
AU2003301226A1 (en) * | 2002-12-20 | 2004-07-22 | Pharmacia Corp | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 |
WO2008006540A1 (fr) * | 2006-07-12 | 2008-01-17 | Syngenta Participations Ag | Dérivés de triazolpyridine utilisés comme herbicides |
WO2009137201A1 (fr) * | 2008-04-04 | 2009-11-12 | Cv Therapeutics, Inc. | Dérivés de triazolopyridinone destinés à être utilisés comme inhibiteurs de la stéaroyl-coa désaturase |
WO2010096722A1 (fr) * | 2009-02-20 | 2010-08-26 | Takeda Pharmaceutical Company Limited | 3-oxo-2,3-dihydro-[1,2,4]triazolo[4, 3-a]pyridines utilisées comme inhibiteurs de l'époxyde hydrolase soluble (eh soluble) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0381033A1 (fr) * | 1989-01-31 | 1990-08-08 | F. Hoffmann-La Roche Ag | Amides d'acides carboxyliques et amides sulfoniques |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8913011D0 (en) * | 1989-06-06 | 1989-07-26 | Wellcome Found | Anticonvulsant pyrazines |
US5166154A (en) * | 1989-10-17 | 1992-11-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Imidazo[1,2-a]piperazines |
US5278161A (en) * | 1990-06-28 | 1994-01-11 | Hoffmann-La Roche Inc. | Amino acid derivatives useful as renin inhibitors |
-
1994
- 1994-02-22 HU HU9502028A patent/HUT71796A/hu unknown
- 1994-02-22 WO PCT/US1994/001881 patent/WO1994018981A1/fr not_active Application Discontinuation
- 1994-02-22 CZ CZ952108A patent/CZ210895A3/cs unknown
- 1994-02-22 EP EP94909745A patent/EP0684823A4/fr not_active Withdrawn
- 1994-02-22 JP JP51922094A patent/JP3173792B2/ja not_active Expired - Fee Related
- 1994-02-22 CN CN94191248A patent/CN1118139A/zh active Pending
- 1994-02-22 CA CA002155123A patent/CA2155123A1/fr not_active Abandoned
- 1994-02-22 PL PL94310386A patent/PL310386A1/xx unknown
- 1994-02-22 AU AU62465/94A patent/AU680240B2/en not_active Ceased
- 1994-02-22 NZ NZ262664A patent/NZ262664A/en unknown
- 1994-02-22 SK SK1024-95A patent/SK102495A3/sk unknown
-
1995
- 1995-08-15 BG BG99863A patent/BG99863A/xx unknown
- 1995-08-21 NO NO953270A patent/NO953270L/no unknown
- 1995-08-21 FI FI953916A patent/FI953916A/fi not_active Application Discontinuation
- 1995-08-21 KR KR1019950703563A patent/KR960700722A/ko not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0381033A1 (fr) * | 1989-01-31 | 1990-08-08 | F. Hoffmann-La Roche Ag | Amides d'acides carboxyliques et amides sulfoniques |
Non-Patent Citations (2)
Title |
---|
B.C. ASKEW ET AL.: "Non-peptide glycoprotein IIb/IIIa inhibitors.", BIOORG. MED. CHEM. LETT., vol. 5, no. 5, 1995, pages 475 - 480, XP000670733 * |
See also references of WO9418981A1 * |
Also Published As
Publication number | Publication date |
---|---|
SK102495A3 (en) | 1997-01-08 |
NO953270L (no) | 1995-10-19 |
FI953916A0 (fi) | 1995-08-21 |
WO1994018981A1 (fr) | 1994-09-01 |
KR960700722A (ko) | 1996-02-24 |
CZ210895A3 (en) | 1996-02-14 |
NZ262664A (en) | 1997-04-24 |
BG99863A (en) | 1996-02-29 |
PL310386A1 (en) | 1995-12-11 |
CN1118139A (zh) | 1996-03-06 |
JPH08507072A (ja) | 1996-07-30 |
FI953916A (fi) | 1995-08-21 |
HU9502028D0 (en) | 1995-09-28 |
HUT71796A (en) | 1996-02-28 |
EP0684823A1 (fr) | 1995-12-06 |
AU680240B2 (en) | 1997-07-24 |
AU6246594A (en) | 1994-09-14 |
NO953270D0 (no) | 1995-08-21 |
CA2155123A1 (fr) | 1994-09-01 |
JP3173792B2 (ja) | 2001-06-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 19950922 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 19970522 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
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17Q | First examination report despatched |
Effective date: 19981014 |
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GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
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GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20020122 |