HUT68649A - 6,9-bis(substituted-amino)-benzo[g]isoquinoline-5,10-diones, pharmaceutical compositions comprising the compounds as effective substance and a process for producing of the compounds - Google Patents

6,9-bis(substituted-amino)-benzo[g]isoquinoline-5,10-diones, pharmaceutical compositions comprising the compounds as effective substance and a process for producing of the compounds

Info

Publication number
HUT68649A
HUT68649A HU9302540A HU9302540A HUT68649A HU T68649 A HUT68649 A HU T68649A HU 9302540 A HU9302540 A HU 9302540A HU 9302540 A HU9302540 A HU 9302540A HU T68649 A HUT68649 A HU T68649A
Authority
HU
Hungary
Prior art keywords
alkyl
group
substituted
aralkyl
phenyl
Prior art date
Application number
HU9302540A
Other languages
English (en)
Other versions
HU215967B (hu
Inventor
A Paul Krapcho
Original Assignee
Univ Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vermont filed Critical Univ Vermont
Publication of HUT68649A publication Critical patent/HUT68649A/hu
Publication of HU215967B publication Critical patent/HU215967B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
HU9302540A 1991-03-08 1992-03-09 Eljárás 6,9-bisz(helyettesített amino)-benzo[g]izokinolin-5,10-dion-származékok és e vegyületeket hatóanyagként tartalmazó gyógyászati készítmények előállítására HU215967B (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66595491A 1991-03-08 1991-03-08
US82730292A 1992-01-29 1992-01-29

Publications (2)

Publication Number Publication Date
HUT68649A true HUT68649A (en) 1995-07-28
HU215967B HU215967B (hu) 1999-03-29

Family

ID=27099336

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9302540A HU215967B (hu) 1991-03-08 1992-03-09 Eljárás 6,9-bisz(helyettesített amino)-benzo[g]izokinolin-5,10-dion-származékok és e vegyületeket hatóanyagként tartalmazó gyógyászati készítmények előállítására

Country Status (22)

Country Link
EP (2) EP0575526A1 (hu)
JP (1) JP3009465B2 (hu)
KR (1) KR100193593B1 (hu)
AT (1) ATE153018T1 (hu)
AU (1) AU663494B2 (hu)
BR (1) BR9205740A (hu)
CA (1) CA2104582A1 (hu)
CZ (1) CZ286180B6 (hu)
DE (1) DE69219646T2 (hu)
DK (1) DK0503537T3 (hu)
ES (1) ES2104753T3 (hu)
FI (1) FI103575B (hu)
GR (1) GR3024436T3 (hu)
HU (1) HU215967B (hu)
IE (1) IE920754A1 (hu)
IL (1) IL102087A (hu)
MX (1) MX9201020A (hu)
NZ (1) NZ241868A (hu)
RU (1) RU2129546C1 (hu)
SG (1) SG66252A1 (hu)
TW (1) TW201735B (hu)
WO (1) WO1992015300A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA936396B (en) * 1992-09-08 1994-06-13 Univ Vermont 4-Substituted 6,9-bis(substituted-amino)benzo[g] isoquinoline-5,10,diones
US5519029A (en) * 1992-09-08 1996-05-21 Boehringer Mannheim Italia, S.P.A. 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
US5587382A (en) * 1994-03-28 1996-12-24 Boehringer Mannheim Italia, Spa 6,9-bis[(2-aminoethyl) amino]benzo [g]isoquinoline-5,10- dione dimaleate; an aza-anthracenedione with reduced cardiotoxicity
US6747039B2 (en) 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
ITMI20021040A1 (it) 2002-05-16 2003-11-17 Novuspharma Spa Composizioni farmaceutiche iniettabili di un derivato antracenedionico ad attivita' antitumorale
WO2005097128A1 (en) * 2004-03-30 2005-10-20 Novacea, Inc. 1,4-bis-n-oxide azaanthracenediones and the use thereof
WO2008103320A1 (en) * 2007-02-16 2008-08-28 Novacea, Inc. Methods of treating ophthalmic disorders with anthraquinones
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EA019295B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Соединения пуриновых нуклеозидов и способ их получения
MX2011006891A (es) 2008-12-23 2011-10-06 Pharmasset Inc Fosforamidatos de nucleosidos.
WO2010075517A2 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Nucleoside analogs
HUE034239T2 (hu) 2010-03-31 2018-02-28 Gilead Pharmasset Llc Eljárás (S)-izopropil 2-(((S)(perfluorfenoxi)(fenoxi)foszforil)amino)propanoát kristályosítására
CN104513201B (zh) * 2013-09-28 2017-12-26 正大天晴药业集团股份有限公司 马来酸匹杉琼的结晶
CN104557704B (zh) * 2013-10-28 2017-05-10 北京凯莱天成医药科技有限公司 一种匹杉琼马来酸盐的制备方法
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2051005A (en) * 1933-09-19 1936-08-11 Gen Aniline Works Inc Process of producing n-substitution products of 1, 4-diaminoanthraquinones
US2552263A (en) * 1947-09-27 1951-05-08 Eastman Kodak Co alpha-anthrapyridinequinone compounds
ZA774443B (en) * 1977-07-22 1978-06-28 Allied Chem Anthrquinone compounds as anti-cancer agents
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
EP0270306B1 (en) * 1986-12-01 1991-03-27 Sumitomo Chemical Company, Limited Anthrapyridone compounds, their production process and their use

Also Published As

Publication number Publication date
FI933895A (fi) 1993-09-07
IL102087A (en) 1996-09-12
EP0503537A1 (en) 1992-09-16
SG66252A1 (en) 1999-07-20
BR9205740A (pt) 1994-09-27
DK0503537T3 (da) 1997-12-15
HU215967B (hu) 1999-03-29
DE69219646T2 (de) 1997-10-02
WO1992015300A1 (en) 1992-09-17
FI103575B1 (fi) 1999-07-30
ATE153018T1 (de) 1997-05-15
CA2104582A1 (en) 1992-09-17
DE69219646D1 (de) 1997-06-19
IE920754A1 (en) 1992-09-09
AU663494B2 (en) 1995-10-12
KR100193593B1 (ko) 1999-06-15
RU2129546C1 (ru) 1999-04-27
NZ241868A (en) 1995-05-26
JP3009465B2 (ja) 2000-02-14
TW201735B (hu) 1993-03-11
GR3024436T3 (en) 1997-11-28
CZ286180B6 (cs) 2000-02-16
EP0503537B1 (en) 1997-05-14
FI933895A0 (fi) 1993-09-07
EP0575526A1 (en) 1993-12-29
CZ184793A3 (en) 1994-06-15
AU1580392A (en) 1992-10-06
ES2104753T3 (es) 1997-10-16
FI103575B (fi) 1999-07-30
MX9201020A (es) 1993-11-01
JPH06511230A (ja) 1994-12-15
EP0575526A4 (hu) 1994-03-30

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