HUP9904410A2 - Eljárás 11béta, 21-dihidroxi-2'-metil-5'bétaH-pregna-1,4-dieno[17,16-d]oxazol-3,20-dion tisztítására - Google Patents
Eljárás 11béta, 21-dihidroxi-2'-metil-5'bétaH-pregna-1,4-dieno[17,16-d]oxazol-3,20-dion tisztításáraInfo
- Publication number
- HUP9904410A2 HUP9904410A2 HU9904410A HUP9904410A HUP9904410A2 HU P9904410 A2 HUP9904410 A2 HU P9904410A2 HU 9904410 A HU9904410 A HU 9904410A HU P9904410 A HUP9904410 A HU P9904410A HU P9904410 A2 HUP9904410 A2 HU P9904410A2
- Authority
- HU
- Hungary
- Prior art keywords
- dieno
- pregna
- dione
- dihydroxy
- water
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000011347 resin Substances 0.000 abstract 3
- 229920005989 resin Polymers 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 235000010633 broth Nutrition 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000005504 styryl group Chemical group 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0068—Nitrogen and oxygen at position 16(17)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
A találmány az (I) képletű 11,21-dihidrőxi-2'-metil-5'H-pregna-1,4-dienő[17,16-d]őxazől-3,20-diőn tisztítási eljárására vőnatkőzik,amelynek sőrán a) a fermentlevekből vagy eljárási főlyadékőkból kapőtt vizes őldatbanlévő vegyületet egy sztiril- vagy akrilmátrixszal rendelkezőpőlimergyanta adszőrbensen adszőrbeálják; b) a gyantát vízzel mőssák; c) majd a fenti vegyületet egy vízzel elegyedő szerves őldószerből ésvízből álló, 10-50 tömeg% vizet tartalmazó keverékkel elűálvadeszőrbeálják a gyantáról; d) az elűátűmőt betöményítik, és az (I) képletű vegyületet szűrésselkinyerik. (I) ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96102325 | 1996-02-16 | ||
| PCT/EP1996/005392 WO1997030068A1 (en) | 1996-02-16 | 1996-12-04 | PROCESS FOR THE PURIFICATION OF 11β-21-DIHYDROXY-2'-METHYL-5'βH-PREGNA-1,4-DIENO[17,16-D]OXAZOLE-3,20-DIONE |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9904410A2 true HUP9904410A2 (hu) | 2000-05-28 |
| HUP9904410A3 HUP9904410A3 (en) | 2002-05-28 |
| HU226936B1 HU226936B1 (en) | 2010-03-29 |
Family
ID=8222483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9904410A HU226936B1 (en) | 1996-02-16 | 1996-12-04 | Process for the purification of 11betha-21-dihydroxy-2'-methyl-5'betha-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6228851B1 (hu) |
| EP (1) | EP0885240B1 (hu) |
| JP (1) | JP4076098B2 (hu) |
| KR (1) | KR100440352B1 (hu) |
| CN (1) | CN1131236C (hu) |
| AT (1) | ATE198600T1 (hu) |
| AU (1) | AU709171B2 (hu) |
| CA (1) | CA2246520C (hu) |
| DE (1) | DE69611548T2 (hu) |
| DK (1) | DK0885240T3 (hu) |
| EA (1) | EA000789B1 (hu) |
| ES (1) | ES2153996T3 (hu) |
| GR (1) | GR3035208T3 (hu) |
| HK (1) | HK1018276A1 (hu) |
| HU (1) | HU226936B1 (hu) |
| IL (1) | IL125414A (hu) |
| NO (1) | NO311029B1 (hu) |
| NZ (1) | NZ324300A (hu) |
| PT (1) | PT885240E (hu) |
| WO (1) | WO1997030068A1 (hu) |
| ZA (1) | ZA971214B (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006028817A1 (de) * | 2006-06-21 | 2007-12-27 | Evonik Degussa Gmbh | Aufarbeitung von Reaktionslösungen aus Ganzzell-Biotransformationen |
-
1996
- 1996-12-04 AU AU11758/97A patent/AU709171B2/en not_active Expired
- 1996-12-04 AT AT96942325T patent/ATE198600T1/de active
- 1996-12-04 KR KR10-1998-0706178A patent/KR100440352B1/ko not_active IP Right Cessation
- 1996-12-04 HU HU9904410A patent/HU226936B1/hu unknown
- 1996-12-04 ES ES96942325T patent/ES2153996T3/es not_active Expired - Lifetime
- 1996-12-04 NZ NZ324300A patent/NZ324300A/xx not_active IP Right Cessation
- 1996-12-04 CN CN96180009A patent/CN1131236C/zh not_active Expired - Lifetime
- 1996-12-04 CA CA002246520A patent/CA2246520C/en not_active Expired - Lifetime
- 1996-12-04 EA EA199800732A patent/EA000789B1/ru not_active IP Right Cessation
- 1996-12-04 JP JP52891697A patent/JP4076098B2/ja not_active Expired - Lifetime
- 1996-12-04 PT PT96942325T patent/PT885240E/pt unknown
- 1996-12-04 EP EP96942325A patent/EP0885240B1/en not_active Expired - Lifetime
- 1996-12-04 WO PCT/EP1996/005392 patent/WO1997030068A1/en active IP Right Grant
- 1996-12-04 DE DE69611548T patent/DE69611548T2/de not_active Expired - Lifetime
- 1996-12-04 IL IL12541496A patent/IL125414A/xx not_active IP Right Cessation
- 1996-12-04 US US09/117,882 patent/US6228851B1/en not_active Expired - Lifetime
- 1996-12-04 DK DK96942325T patent/DK0885240T3/da active
-
1997
- 1997-02-13 ZA ZA9701214A patent/ZA971214B/xx unknown
-
1998
- 1998-08-11 NO NO19983665A patent/NO311029B1/no not_active IP Right Cessation
-
1999
- 1999-07-30 HK HK99103289A patent/HK1018276A1/xx not_active IP Right Cessation
-
2001
- 2001-01-11 GR GR20000402867T patent/GR3035208T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO983665D0 (no) | 1998-08-11 |
| KR100440352B1 (ko) | 2004-09-18 |
| NO983665L (no) | 1998-08-11 |
| ATE198600T1 (de) | 2001-01-15 |
| NZ324300A (en) | 1999-02-25 |
| JP4076098B2 (ja) | 2008-04-16 |
| DK0885240T3 (da) | 2001-01-29 |
| HU226936B1 (en) | 2010-03-29 |
| EP0885240B1 (en) | 2001-01-10 |
| CA2246520C (en) | 2004-03-02 |
| CN1131236C (zh) | 2003-12-17 |
| NO311029B1 (no) | 2001-10-01 |
| IL125414A (en) | 2003-10-31 |
| HUP9904410A3 (en) | 2002-05-28 |
| DE69611548T2 (de) | 2001-06-07 |
| CN1209137A (zh) | 1999-02-24 |
| US6228851B1 (en) | 2001-05-08 |
| EA000789B1 (ru) | 2000-04-24 |
| GR3035208T3 (en) | 2001-04-30 |
| HK1018276A1 (en) | 1999-12-17 |
| IL125414A0 (en) | 1999-03-12 |
| JP2000511878A (ja) | 2000-09-12 |
| KR19990082445A (ko) | 1999-11-25 |
| EA199800732A1 (ru) | 1999-02-25 |
| PT885240E (pt) | 2001-04-30 |
| DE69611548D1 (de) | 2001-02-15 |
| EP0885240A1 (en) | 1998-12-23 |
| WO1997030068A1 (en) | 1997-08-21 |
| CA2246520A1 (en) | 1997-08-21 |
| AU1175897A (en) | 1997-09-02 |
| ES2153996T3 (es) | 2001-03-16 |
| ZA971214B (en) | 1997-11-19 |
| AU709171B2 (en) | 1999-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: SANOFI AVENTIS SPA, IT Free format text: FORMER OWNER(S): AVENTIS BULK S.P.A., IT; GRUPPO LEPETIT S.P.A., IT |
|
| FH91 | Appointment of a representative |
Free format text: FORMER REPRESENTATIVE(S): S.B.G. & K. SZABADALMI UEGYVIVOEI IRODA, HU Representative=s name: DANUBIA SZABADALMI ES JOGI IRODA KFT., HU |
|
| FH92 | Termination of representative |
Representative=s name: S.B.G. & K. SZABADALMI UEGYVIVOEI IRODA, HU |