GB1156844A - Process for Recovering Nystatin. - Google Patents
Process for Recovering Nystatin.Info
- Publication number
- GB1156844A GB1156844A GB3172866A GB3172866A GB1156844A GB 1156844 A GB1156844 A GB 1156844A GB 3172866 A GB3172866 A GB 3172866A GB 3172866 A GB3172866 A GB 3172866A GB 1156844 A GB1156844 A GB 1156844A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nystatin
- acid
- amine
- recovering
- mycelium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,156,844. Purification of nystatin. E. R. SQUIBB & SONS Inc. 14 July, 1966, No. 31728/66. Heading C2A. Nystatin is recovered from a nystatin fermentation broth by separating the mycelium from the broth, preferably washing with water, and treating the mycelium with an aqueous C 1-8 alkanol and with an acid and an amine, or the corresponding salt, at a substantially neutral pH and recovering the nystatin from the alcoholic extract. The pH is preferably 6À0 to 6À5. The alcoholic extract is concentrated to remove the organic solvent and the nystatin is recrystallized from aqueous acetone or other water-miscible ketone. The acid may be organic, e.g. oxalic, malonic, succinic or citric, but is preferably a mineral acid, e.g. sulphuric acid. The amine may be a primary, secondary or tertiary amine. The preferred solvent is methanol containing the sulphate salt of a tertiary amine such as triethylamine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3172866A GB1156844A (en) | 1966-07-14 | 1966-07-14 | Process for Recovering Nystatin. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3172866A GB1156844A (en) | 1966-07-14 | 1966-07-14 | Process for Recovering Nystatin. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1156844A true GB1156844A (en) | 1969-07-02 |
Family
ID=10327502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3172866A Expired GB1156844A (en) | 1966-07-14 | 1966-07-14 | Process for Recovering Nystatin. |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1156844A (en) |
-
1966
- 1966-07-14 GB GB3172866A patent/GB1156844A/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |