HUP9904035A2 - Módosított kristály formájú R(-)-N-(4,4-di(3-metil-tien-2-il)-but-3-enil)-nipekotinsav-hidroklorid - Google Patents
Módosított kristály formájú R(-)-N-(4,4-di(3-metil-tien-2-il)-but-3-enil)-nipekotinsav-hidrokloridInfo
- Publication number
- HUP9904035A2 HUP9904035A2 HU9904035A HUP9904035A HUP9904035A2 HU P9904035 A2 HUP9904035 A2 HU P9904035A2 HU 9904035 A HU9904035 A HU 9904035A HU P9904035 A HUP9904035 A HU P9904035A HU P9904035 A2 HUP9904035 A2 HU P9904035A2
- Authority
- HU
- Hungary
- Prior art keywords
- enyl
- acid hydrochloride
- methylthien
- crystalline form
- nipecotic acid
- Prior art date
Links
- 206010015037 epilepsy Diseases 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
A találmány tárgya vízmentes kristály főrmájú R(-)-N-(4,4-di(3-metil-tien-2-il)-bűt-3-enil)-nipekőtinsav-hidrőklőrid (generikűs néventriagabin). A találmány szerinti vegyület GABA-felvétellel kapcsőlatősmegbetegedések és epilepszia kezelésére használhatók. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK66196 | 1996-06-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9904035A2 true HUP9904035A2 (hu) | 2000-05-28 |
HUP9904035A3 HUP9904035A3 (en) | 2000-07-28 |
Family
ID=8096101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9904035A HUP9904035A3 (en) | 1996-06-14 | 1997-06-03 | Modified crystalline form of the r-(-)-n-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotic acid hydrochloride |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0906309B1 (hu) |
JP (1) | JP2000511909A (hu) |
CN (1) | CN1636565A (hu) |
AR (1) | AR008236A1 (hu) |
AT (1) | ATE223405T1 (hu) |
AU (1) | AU723267B2 (hu) |
BR (1) | BR9709725A (hu) |
CZ (1) | CZ295578B6 (hu) |
DE (1) | DE69715196T2 (hu) |
DK (1) | DK0906309T3 (hu) |
ES (1) | ES2181002T3 (hu) |
HU (1) | HUP9904035A3 (hu) |
IL (1) | IL127469A (hu) |
NO (1) | NO316889B1 (hu) |
PL (1) | PL190858B1 (hu) |
PT (1) | PT906309E (hu) |
RU (1) | RU2177478C2 (hu) |
UA (1) | UA52661C2 (hu) |
WO (1) | WO1997047619A1 (hu) |
ZA (1) | ZA975266B (hu) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5914333A (en) * | 1996-07-31 | 1999-06-22 | Novo Nordisk A/S | Treatment of psychotic disorders |
IE970588A1 (en) | 1997-08-01 | 2000-08-23 | Elan Corp Plc | Controlled release pharmaceutical compositions containing tiagabine |
WO1999006045A1 (en) * | 1997-08-01 | 1999-02-11 | Elan Corporation, Plc | Controlled release pharmaceutical compositions containing tiagabine |
CN1314684C (zh) * | 2003-12-24 | 2007-05-09 | 中国科学院上海有机化学研究所 | 噻加宾及其消旋体和s-构型的合成方法及其无定形粉末的制法 |
GB0402118D0 (en) * | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
WO2005092886A1 (en) * | 2004-03-29 | 2005-10-06 | Ranbaxy Laboratories Limited | Process for the preparation of amorphous form of tiagabine |
US20080064727A1 (en) * | 2006-08-18 | 2008-03-13 | Cephalon, Inc. | Crystalline forms of tiagabine hydrochloride |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK288385D0 (da) * | 1985-06-26 | 1985-06-26 | Novo Industri As | Aminosyrederivater |
DK58291D0 (da) * | 1991-04-02 | 1991-04-02 | Novo Nordisk As | Krystalinsk stof og dets fremstilling |
-
1997
- 1997-03-06 UA UA98126589A patent/UA52661C2/uk unknown
- 1997-06-03 DK DK97927006T patent/DK0906309T3/da active
- 1997-06-03 WO PCT/DK1997/000244 patent/WO1997047619A1/en active IP Right Grant
- 1997-06-03 AT AT97927006T patent/ATE223405T1/de active
- 1997-06-03 DE DE69715196T patent/DE69715196T2/de not_active Expired - Lifetime
- 1997-06-03 EP EP97927006A patent/EP0906309B1/en not_active Expired - Lifetime
- 1997-06-03 BR BR9709725A patent/BR9709725A/pt not_active IP Right Cessation
- 1997-06-03 PT PT97927006T patent/PT906309E/pt unknown
- 1997-06-03 ES ES97927006T patent/ES2181002T3/es not_active Expired - Lifetime
- 1997-06-03 HU HU9904035A patent/HUP9904035A3/hu unknown
- 1997-06-03 PL PL330424A patent/PL190858B1/pl unknown
- 1997-06-03 CZ CZ19984019A patent/CZ295578B6/cs not_active IP Right Cessation
- 1997-06-03 CN CNA2004100926232A patent/CN1636565A/zh active Pending
- 1997-06-03 AU AU31653/97A patent/AU723267B2/en not_active Expired
- 1997-06-03 RU RU99100703/04A patent/RU2177478C2/ru not_active IP Right Cessation
- 1997-06-03 JP JP10501077A patent/JP2000511909A/ja not_active Ceased
- 1997-06-03 IL IL12746997A patent/IL127469A/xx not_active IP Right Cessation
- 1997-06-13 ZA ZA9705266A patent/ZA975266B/xx unknown
- 1997-06-13 AR ARP970102614A patent/AR008236A1/es active IP Right Grant
-
1998
- 1998-12-11 NO NO19985809A patent/NO316889B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0906309A1 (en) | 1999-04-07 |
ATE223405T1 (de) | 2002-09-15 |
PL330424A1 (en) | 1999-05-10 |
NO985809L (no) | 1998-12-11 |
AU3165397A (en) | 1998-01-07 |
RU2177478C2 (ru) | 2001-12-27 |
AR008236A1 (es) | 1999-12-29 |
ZA975266B (en) | 1998-02-04 |
DE69715196T2 (de) | 2003-05-15 |
DE69715196D1 (de) | 2002-10-10 |
WO1997047619A1 (en) | 1997-12-18 |
JP2000511909A (ja) | 2000-09-12 |
DK0906309T3 (da) | 2002-12-16 |
NO316889B1 (no) | 2004-06-14 |
EP0906309B1 (en) | 2002-09-04 |
IL127469A (en) | 2001-01-11 |
ES2181002T3 (es) | 2003-02-16 |
HUP9904035A3 (en) | 2000-07-28 |
UA52661C2 (uk) | 2003-01-15 |
IL127469A0 (en) | 1999-10-28 |
NO985809D0 (no) | 1998-12-11 |
BR9709725A (pt) | 1999-08-10 |
PL190858B1 (pl) | 2006-02-28 |
CN1636565A (zh) | 2005-07-13 |
CZ295578B6 (cs) | 2005-08-17 |
CZ401998A3 (cs) | 1999-06-16 |
AU723267B2 (en) | 2000-08-24 |
PT906309E (pt) | 2002-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |