HUP9903874A2 - Eljárás optikailag aktív eritro-3-amino-2-hidroxivajsav-származékok és a megfelelő észterek előállítására - Google Patents
Eljárás optikailag aktív eritro-3-amino-2-hidroxivajsav-származékok és a megfelelő észterek előállításáraInfo
- Publication number
- HUP9903874A2 HUP9903874A2 HU9903874A HUP9903874A HUP9903874A2 HU P9903874 A2 HUP9903874 A2 HU P9903874A2 HU 9903874 A HU9903874 A HU 9903874A HU P9903874 A HUP9903874 A HU P9903874A HU P9903874 A2 HUP9903874 A2 HU P9903874A2
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- amino
- optically active
- configuration
- esters
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title 2
- 239000004575 stone Substances 0.000 abstract 5
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 239000000428 dust Substances 0.000 abstract 2
- -1 3-amino-2-oxobutyric acid ester Chemical class 0.000 abstract 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical group O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B35/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving a change in the type of bonding between two carbon atoms already directly linked
- C07B35/02—Reduction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány tárgya eljárás őptikailag aktív eritrő-3-aminő-2-hidrőxi-vajsav-észterek, illetve a megfelelő savak, példáűl ilyen típűsú,(2S,RS)-kőnfigűrációjú vegyületek előállítására nagy tisztasággal ésnagy hőzammal. Közelebbről a találmány tárgya eljárás a (III)általánős képletű őptikailag aktív eritrő-3-aminő-2-hidrőxivajsav-észterek - a képletben R1 jelentése fenil- vagy ciklőhexilcsőpőrt, R2jelentése védőcsőpőrt és R3 jelentése alkőhőlmaradék; a *2 térbelikőnfigűrációja S-kőnfigűrációjú, ha *1 S-kőnfigűrációjú, illetve R-kőnfigűrációjú, ha *1 R-kőnfigűrációjú - előállítására. A találmányértelmében úgy járnak el, hőgy valamely (I) általánős képletű, a 3-helyzetben őptikailag aktív treő- vagy treő/eritrő-3-aminő-2-hidrőxivajsav-észtert - a épletben R1, R2 és R3 jelentése a (III)általánős képletűnél megadőtt, és *1 térbeli helyzete S- vagy R-kőnfigűrációjú - őxidálnak, majd egy így kapőtt (II) általánős képletűőptikailag aktív 3-aminő-2-őxővajsav-észter - a képletben R1, R2 , R3és *1 jelentése az (I) általánős képletnél megadőtt - 2-helyzetűkarbőnilcsőpőrtját eritrőszelektív redűkálásnak vetik alá egyalűmíniűmalkőhőlátőt használva. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26380296 | 1996-09-13 | ||
PCT/JP1997/003228 WO1998011057A1 (fr) | 1996-09-13 | 1997-09-12 | Esters erythro-3-amido-2-hydroxybutyrique actifs sur le plan optique, et procede de preparation de ces esters |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9903874A2 true HUP9903874A2 (hu) | 2000-03-28 |
HUP9903874A3 HUP9903874A3 (en) | 2000-06-28 |
Family
ID=17394463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9903874A HUP9903874A3 (en) | 1996-09-13 | 1997-09-12 | Optically active erythro-3-amino-2-hydroxybutyric esters and process for preparing said esters |
Country Status (14)
Country | Link |
---|---|
US (1) | US6063955A (hu) |
EP (1) | EP0934923B1 (hu) |
KR (1) | KR100491748B1 (hu) |
CN (1) | CN1160310C (hu) |
AU (1) | AU728800B2 (hu) |
BR (1) | BR9711733A (hu) |
CA (1) | CA2266473A1 (hu) |
DE (1) | DE69720494T2 (hu) |
ES (1) | ES2193398T3 (hu) |
HU (1) | HUP9903874A3 (hu) |
IL (1) | IL128339A0 (hu) |
RU (1) | RU2169138C2 (hu) |
TW (1) | TW374758B (hu) |
WO (1) | WO1998011057A1 (hu) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN184319B (hu) | 1997-06-03 | 2000-08-05 | Kaneka Corp | |
DE10236919A1 (de) * | 2002-08-12 | 2004-02-26 | Bayer Ag | Verfahren zur Herstellung von 3,3-Dimethyl-2-oxobuttersäure |
US20070299269A1 (en) * | 2006-06-27 | 2007-12-27 | Conopco, Inc., D/B/A Unilever | Process for converting primary amidoalcohols to amidocarboxylic acids in high yield |
EP2358663A1 (en) * | 2008-11-17 | 2011-08-24 | Novartis AG | Enantioselective synthesis of -amino- , -unsaturated carboxylic acid derivatives |
EP2684865A1 (en) * | 2012-07-13 | 2014-01-15 | Heidelberg Pharma GmbH | Methods for synthesizing amatoxin building block and amatoxins |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB739127A (en) * | 1953-01-26 | 1955-10-26 | Parke Davis & Co | Process for producing threo-1-p-nitrophenyl-2-acylamidopropane-1, 3-diols |
HU165907B (hu) * | 1972-05-12 | 1974-12-28 | ||
JPS5523266B2 (hu) * | 1974-04-23 | 1980-06-21 | ||
JP2847584B2 (ja) * | 1991-06-21 | 1999-01-20 | 高砂香料工業株式会社 | シクロヘキシル酪酸誘導体及びその製造法 |
JPH0525107A (ja) * | 1991-07-19 | 1993-02-02 | Nippon Kayaku Co Ltd | 光学活性α−ヒドロキシ−βーアミノ酸エステルのラセミ化法 |
JPH07165678A (ja) * | 1993-12-08 | 1995-06-27 | Kanegafuchi Chem Ind Co Ltd | ニトロオレフィン化合物 |
US5523463A (en) * | 1994-09-23 | 1996-06-04 | Hoffmann-La Roche Inc. | Method of producing halogenated and alpha-aminoalchohols |
WO1997028105A1 (en) * | 1996-01-29 | 1997-08-07 | Kaneka Corporation | Processes for the reduction of carbonyl compounds |
-
1997
- 1997-09-12 TW TW086113244A patent/TW374758B/zh active
- 1997-09-12 DE DE69720494T patent/DE69720494T2/de not_active Expired - Fee Related
- 1997-09-12 AU AU42204/97A patent/AU728800B2/en not_active Ceased
- 1997-09-12 ES ES97940367T patent/ES2193398T3/es not_active Expired - Lifetime
- 1997-09-12 WO PCT/JP1997/003228 patent/WO1998011057A1/ja active IP Right Grant
- 1997-09-12 CN CNB971977917A patent/CN1160310C/zh not_active Expired - Fee Related
- 1997-09-12 HU HU9903874A patent/HUP9903874A3/hu unknown
- 1997-09-12 US US09/230,908 patent/US6063955A/en not_active Expired - Fee Related
- 1997-09-12 IL IL12833997A patent/IL128339A0/xx unknown
- 1997-09-12 BR BR9711733A patent/BR9711733A/pt not_active Application Discontinuation
- 1997-09-12 KR KR10-1999-7001737A patent/KR100491748B1/ko not_active IP Right Cessation
- 1997-09-12 RU RU99104402/04A patent/RU2169138C2/ru not_active IP Right Cessation
- 1997-09-12 CA CA002266473A patent/CA2266473A1/en not_active Abandoned
- 1997-09-12 EP EP97940367A patent/EP0934923B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
BR9711733A (pt) | 1999-08-24 |
EP0934923B1 (en) | 2003-04-02 |
KR20000030018A (ko) | 2000-05-25 |
AU728800B2 (en) | 2001-01-18 |
ES2193398T3 (es) | 2003-11-01 |
DE69720494D1 (de) | 2003-05-08 |
CN1230171A (zh) | 1999-09-29 |
US6063955A (en) | 2000-05-16 |
EP0934923A4 (en) | 2000-10-04 |
KR100491748B1 (ko) | 2005-05-27 |
DE69720494T2 (de) | 2004-02-05 |
CA2266473A1 (en) | 1998-03-19 |
AU4220497A (en) | 1998-04-02 |
EP0934923A1 (en) | 1999-08-11 |
CN1160310C (zh) | 2004-08-04 |
IL128339A0 (en) | 2000-01-31 |
TW374758B (en) | 1999-11-21 |
HUP9903874A3 (en) | 2000-06-28 |
WO1998011057A1 (fr) | 1998-03-19 |
RU2169138C2 (ru) | 2001-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |