HUP9903874A2 - Eljárás optikailag aktív eritro-3-amino-2-hidroxivajsav-származékok és a megfelelő észterek előállítására - Google Patents

Eljárás optikailag aktív eritro-3-amino-2-hidroxivajsav-származékok és a megfelelő észterek előállítására

Info

Publication number
HUP9903874A2
HUP9903874A2 HU9903874A HUP9903874A HUP9903874A2 HU P9903874 A2 HUP9903874 A2 HU P9903874A2 HU 9903874 A HU9903874 A HU 9903874A HU P9903874 A HUP9903874 A HU P9903874A HU P9903874 A2 HUP9903874 A2 HU P9903874A2
Authority
HU
Hungary
Prior art keywords
formula
amino
optically active
configuration
esters
Prior art date
Application number
HU9903874A
Other languages
English (en)
Inventor
Hisao Satoh
Kenichi Yamamoto
Original Assignee
Nippon Kayaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Kabushiki Kaisha filed Critical Nippon Kayaku Kabushiki Kaisha
Publication of HUP9903874A2 publication Critical patent/HUP9903874A2/hu
Publication of HUP9903874A3 publication Critical patent/HUP9903874A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B35/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving a change in the type of bonding between two carbon atoms already directly linked
    • C07B35/02—Reduction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya eljárás őptikailag aktív eritrő-3-aminő-2-hidrőxi-vajsav-észterek, illetve a megfelelő savak, példáűl ilyen típűsú,(2S,RS)-kőnfigűrációjú vegyületek előállítására nagy tisztasággal ésnagy hőzammal. Közelebbről a találmány tárgya eljárás a (III)általánős képletű őptikailag aktív eritrő-3-aminő-2-hidrőxivajsav-észterek - a képletben R1 jelentése fenil- vagy ciklőhexilcsőpőrt, R2jelentése védőcsőpőrt és R3 jelentése alkőhőlmaradék; a *2 térbelikőnfigűrációja S-kőnfigűrációjú, ha *1 S-kőnfigűrációjú, illetve R-kőnfigűrációjú, ha *1 R-kőnfigűrációjú - előállítására. A találmányértelmében úgy járnak el, hőgy valamely (I) általánős képletű, a 3-helyzetben őptikailag aktív treő- vagy treő/eritrő-3-aminő-2-hidrőxivajsav-észtert - a épletben R1, R2 és R3 jelentése a (III)általánős képletűnél megadőtt, és *1 térbeli helyzete S- vagy R-kőnfigűrációjú - őxidálnak, majd egy így kapőtt (II) általánős képletűőptikailag aktív 3-aminő-2-őxővajsav-észter - a képletben R1, R2 , R3és *1 jelentése az (I) általánős képletnél megadőtt - 2-helyzetűkarbőnilcsőpőrtját eritrőszelektív redűkálásnak vetik alá egyalűmíniűmalkőhőlátőt használva. ŕ
HU9903874A 1996-09-13 1997-09-12 Optically active erythro-3-amino-2-hydroxybutyric esters and process for preparing said esters HUP9903874A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26380296 1996-09-13
PCT/JP1997/003228 WO1998011057A1 (fr) 1996-09-13 1997-09-12 Esters erythro-3-amido-2-hydroxybutyrique actifs sur le plan optique, et procede de preparation de ces esters

Publications (2)

Publication Number Publication Date
HUP9903874A2 true HUP9903874A2 (hu) 2000-03-28
HUP9903874A3 HUP9903874A3 (en) 2000-06-28

Family

ID=17394463

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903874A HUP9903874A3 (en) 1996-09-13 1997-09-12 Optically active erythro-3-amino-2-hydroxybutyric esters and process for preparing said esters

Country Status (14)

Country Link
US (1) US6063955A (hu)
EP (1) EP0934923B1 (hu)
KR (1) KR100491748B1 (hu)
CN (1) CN1160310C (hu)
AU (1) AU728800B2 (hu)
BR (1) BR9711733A (hu)
CA (1) CA2266473A1 (hu)
DE (1) DE69720494T2 (hu)
ES (1) ES2193398T3 (hu)
HU (1) HUP9903874A3 (hu)
IL (1) IL128339A0 (hu)
RU (1) RU2169138C2 (hu)
TW (1) TW374758B (hu)
WO (1) WO1998011057A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN184319B (hu) 1997-06-03 2000-08-05 Kaneka Corp
DE10236919A1 (de) * 2002-08-12 2004-02-26 Bayer Ag Verfahren zur Herstellung von 3,3-Dimethyl-2-oxobuttersäure
US20070299269A1 (en) * 2006-06-27 2007-12-27 Conopco, Inc., D/B/A Unilever Process for converting primary amidoalcohols to amidocarboxylic acids in high yield
EP2358663A1 (en) * 2008-11-17 2011-08-24 Novartis AG Enantioselective synthesis of -amino- , -unsaturated carboxylic acid derivatives
EP2684865A1 (en) * 2012-07-13 2014-01-15 Heidelberg Pharma GmbH Methods for synthesizing amatoxin building block and amatoxins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB739127A (en) * 1953-01-26 1955-10-26 Parke Davis & Co Process for producing threo-1-p-nitrophenyl-2-acylamidopropane-1, 3-diols
HU165907B (hu) * 1972-05-12 1974-12-28
JPS5523266B2 (hu) * 1974-04-23 1980-06-21
JP2847584B2 (ja) * 1991-06-21 1999-01-20 高砂香料工業株式会社 シクロヘキシル酪酸誘導体及びその製造法
JPH0525107A (ja) * 1991-07-19 1993-02-02 Nippon Kayaku Co Ltd 光学活性α−ヒドロキシ−βーアミノ酸エステルのラセミ化法
JPH07165678A (ja) * 1993-12-08 1995-06-27 Kanegafuchi Chem Ind Co Ltd ニトロオレフィン化合物
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols
WO1997028105A1 (en) * 1996-01-29 1997-08-07 Kaneka Corporation Processes for the reduction of carbonyl compounds

Also Published As

Publication number Publication date
BR9711733A (pt) 1999-08-24
EP0934923B1 (en) 2003-04-02
KR20000030018A (ko) 2000-05-25
AU728800B2 (en) 2001-01-18
ES2193398T3 (es) 2003-11-01
DE69720494D1 (de) 2003-05-08
CN1230171A (zh) 1999-09-29
US6063955A (en) 2000-05-16
EP0934923A4 (en) 2000-10-04
KR100491748B1 (ko) 2005-05-27
DE69720494T2 (de) 2004-02-05
CA2266473A1 (en) 1998-03-19
AU4220497A (en) 1998-04-02
EP0934923A1 (en) 1999-08-11
CN1160310C (zh) 2004-08-04
IL128339A0 (en) 2000-01-31
TW374758B (en) 1999-11-21
HUP9903874A3 (en) 2000-06-28
WO1998011057A1 (fr) 1998-03-19
RU2169138C2 (ru) 2001-06-20

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees